NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	39300-45-3
Chemical Name	dinocap
Substance ID	m-nite-39300-45-3_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Not classified because of no appropriate data on an explosibility, though the substance contains N-O bonds as chemical groups with explosive properties present and has the oxygen balance calculated at -184.4, higher than -200 of the criteria.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Category 4 because of its flash point: 67degC (PM, 13th, 2003, Pensky-Martens closed cup)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Although the grouping relevant to explosive (N-O) was included, the grouping relevant to autoreactive was not included and the data in which autoreactive is indicated was not found, either. So it was considered outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Uses are agricultural chemicals, and even if it contacts the normal temperature air, it does not ignite spontaneously.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the value of LD50 = 834mg/kg calculated from the rat oral LD50 values : 980 (RTECS (2003), HSDB (2003)), 766 (RTECS (2003)) and 950mg/kg (HSDB (2003)), the substance was classified as Category 4.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Considering rabbit dermal LD50 = 9400mg/kg (RTECS (2003)), it was set as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was set as category 2 based on rat LC50 (4h) = 0.36mg/L (RTECS (2003)). In addition, it is presumed that the saturated concentration of this product is very low, and the inhalation test is done in mist conditions.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Since there is the description that human skin is stimulated (ICSC (J), (1997), HSDB (2003)), it was set as category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	By repetition or the long-term contact to the human skin, since there is a report of a patch test positivity (HSDB(2003)) in addition to there is a description that sensitization of the skin may be carried out (ICSC(J)(1997)), it was referred to as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is the positive report in Ames test reporting (RTECS (2003)), other test results containing in vivo cannot be found. So it cannot be classified because of insufficient data	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	There is the report which suggests carcinogenic in a mouse (RTECS (2003)) and reports denies was seen (HSDB (2003)). But data is insufficient and it cannot taxonomic.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) to (6), since one isomer composing this substance, which is an isomer mixture, was regarded as a teratogen, and teratogenic effects were reported at the dose at which no marked maternal toxicity was observed, it was classified in Category 1B. Based on the new information source, the category was changed. [Evidence Data] (1) It was reported that, in a developmental toxicity study with pregnant mice dosed by gavage, in the intermediate-dose (10 mg/kg/day) group and the high-dose (25 mg/kg/day) group showing maternal toxicity, an increase in the incidence of malformations (cleft palate, open eyelids) was observed in fetuses (JMPR (1998)). (2) It was reported that, in a developmental toxicity study by dermal application to pregnant mice, in the highest dose (25 mg/kg/day) group showing no maternal toxicity, teratogenic effects including impaired otolith formation were observed in fetuses (JMPR (1998)). (3) It was reported that impaired otolith development, which was one of teratogenic effects in mice, was also seen in hamsters at doses that cause maternal toxicity, while in an oral administration test with rats, no teratogenicity was observed (JMPR (1998)). (4) It has been established that this substance (dinocap) is an isomer mixture and one isomer, 4-PP (2,6-dinitro-4-[(4RS)-octan-4-yl]phenyl (2E/Z)-but-2-enoate) is responsible for the teratogenic effects observed in mice and the other dinocap isomers, including DE-126 (meptyldinocap, CAS RN 131-72-6), do not share the teratogenic effects (EFSA (2014)). (5) In a developmental toxicity study with female mice dosed by gavage (4 to 25 mg/kg/day, days 6 to 15 of gestation) (about half of the mice in each group were killed on day 18 of gestation and the fetuses were examined. The remaining dams were allowed to naturally deliver and their liveborn pups were observed after birth), a decreasing trend of body weight gain (not significant) was only observed in dams at the high dose (25 mg/kg/day). However, in fetuses, at the intermediate dose (10 mg/kg/day) that causes no maternal toxicity, open eyelids (1/12 litters, one fetus) and cleft palate (3/12 litters, 4 fetuses) were observed, and at the high dose, open eyelids (2/9 litters, 3 fetuses) and an increase of cleft palate (7/9 litters, 65 fetuses) were observed. In naturally-delivered pups, there were an increased incidence of stillborn pups, decreased body weight gain and an increased incidence of litters with pups with head tilt or cleft palate (7 of 9 pups with cleft palate were from the same litter), and in a swimming test on day 43, abnormal swimming postures or ability were observed (JMPR (1998): Part II (Toxicological Evaluation)). (6) It was reported that, in a developmental toxicity study by dermal administration (1 to 25 mg/kg/day, days 6 to 15 of gestation, 4 hours/day) with female mice, local irritation at or above 10 mg/kg/day and one death at the highest dose of 25 mg/kg/day (the relation to the treatment is not clear) were observed in dams. As for developmental effects, it was reported that impaired otolith formation in addition to cleft palate (1/6 litters, 3 fetuses) and open eyelids (1/6 litters, 2 fetuses) was observed in fetuses in the highest dose group (JMPR (1998): Part II (Toxicological Evaluation)). [Reference Data, etc.] (7) In the EU, it was classified in Repr. 1B (EU CLP Classification Results (Accessed Dec. 2021)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	Since there is a report that effect was observed in the liver function as a result of occupational exposure of this product (HSDB (2003) the document of Priority 2), and , that the hepatocyte necrosis was observed in the rat with given dose of the range of Category 2 in a guidance value (RTECS (2003) the document of Priority 2), it was classified into Category 2 (liver).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 48-hour EC50=4.2ppb of Crustacea (Daphnia magna) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=5.98 (PHYSPROP Database, 2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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