NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	39515-41-8
Chemical Name	alpha-cyano-3-phenoxybenzyl 2,2,3,3-tetramethylcyclopropanecarboxylate; fenpropathrin
Substance ID	m-nite-39515-41-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Its autoignition points is 325degC (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), which is > 70degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available. (45-50degC: (Howard (1997), The Society of Synthetic Organic Chemistry, Japan, Dictionary of Organic Compounds, Kodansha Ltd. (1985), PM (14th, 2006))	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Its melting point is <= 55degC. Classification is not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on its rat LD50 values of 60 mg/kg bw and 164 mg/kg bw for male (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)) and 70 mg/kg bw and 107 mg/kg bw for female (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), the substance was classified into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on its rat LD50 value of > 5000 mg/kg bw for both sexes, the substance was classified into "Not classified" (United Nations classification: "Not classified").	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Based on its rat LC50 value of > 0.072 mg/L for both sexes (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), classification is not possible because we cannot determine between Category 2 and "Not classified". (its saturated vapour pressure concentration is 0.000103 mg/L.)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since rabbit tests found that the substance is not irritating (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Since rabbit tests found that the substance causes mild irritation (although chemosis or congestion of the conjunctiva was observed and the substance was judged to be irritating, irritation was very mild and was virtually not problematic) (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), the substance was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Although negative results obtained in Buehler tests using rabbits (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)) indicated that the substance is to be placed into "Not classified" category, we classified it into "Classification not possible" because the results were generated using List 2 data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Since in vivo micronucleus tests using mouse bone marrow gave negative results (Japan Crop Protection Association (Sumitomo Chemical 1989-II)), the substance was classified into the "Not classified" category. Regarding in vitro mutagenicity tests, both Ames tests and chromosomal aberration tests (using cultured Chinese Hamster ovarian cells) gave negative results (Japan Crop Protection Association (Sumitomo Chemical 1989-II)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	In 2-year oral administration tests using rats (CD strain) (male: 0, 1.93, 5.71, 17.06 and 22.8mg/kg/day; female: 0, 2.43, 7.23, 19.45 and 23.98mg/kg/day), tremors were detected as an effect severity of which was correlated with amount of exposure. Other effects related to the test substance or pathological abnormalities that severity was correlated with amount of exposure were not detected (IRIS (2002)). In joint chronic toxicity / carcinogenicity tests using rats (CD strain) (0, 50, 150, 450 and 600 ppm mixed diet), which is presumed to be the same as above-mentioned study, no consistent changes that were related to administration were not detected in hematological, blood biochemistry and histopathological examinations conducted. In addition, with regard to all tumors observed, rates of development were not different between control and treated groups; thus, the test was negative for carcinogenicity (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). Moreover, in 2-year oral administration tests using mice (male: 0, 3.9, 13.7 and 56mg/kg/day; female: 0, 4.2, 16.2 and 65.2mg/kg/day), any exposure-related toxicity was not detected other than marginally increased hyperactivity in female (IRIS (2002)). In combined chronic toxicity / carcinogenicity tests using rats (CD strain) (0, 40, 150 and 600 ppm mixed diet), which is presumed to be the same as above-mentioned study, no administration-related changes were observed in terms of either non-neoplastic or neoplastic changes inspected in histopathological examinations; thus, the test was negative for carcinogenicity (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). From this information, the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In 2-generation oral administration tests using rats, no effects of exposure (at the concentrations (6.0 and 18 mg/kg/day) that induce parental toxicity) were detected using various parameters related to fertility such as pregnancy rate, birthrate and mating ratio; thus, there were no effects on fertility (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). On the other hand, in 3-generation oral administration tests, an increase in tremors and mortality was detected in F2b offspring at the exposure concentrations that cause parental toxicity, while there were no effects of exposure on reproductive toxicity (IRIS (2002)). In developmental toxicity tests using rats (from day 6 to day 15 of pregnancy: 0, 0.4, 1.5, 2, 3, 6 or 10 mg/kg/day), no skeletal malformations were detected at the exposure concentrations that cause parental toxicity, indicating that NOEL is higher than the highest concentration (10 mg/kg/day) tested (IRIS (2002)). In developmental toxicity tests using rabbits (from day 7 to day 19 of pregnancy: 0, 4, 12 or 36 mg/kg/day), no exposure related abnormalities or malformation were detected at the exposure concentrations that cause parental toxicity (IRIS (2002)). From this information, the substance was classified into Category 2 based on the results of 3-generation tests in that an increase in tremors and mortality was detected in offspring at the exposure concentrations that cause parental toxicity.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In acute toxicity tests using rats, muscle cramp, tremors, atactic gait and irregular respiration were observed at the toxic dose (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). Since the LD50 value is 60-164 mg/kg bw, it is presumed that muscle cramp, tremors, atactic gait and irregular respiration occurred at the exposure concentrations which fall under the range of Category 1 guidance values (<= 300 mg/kg bw). Although the substance is to be placed in Category 1 based on the guidance values, it was classified into Category 2 (nervous system) because the results were obtained using List 2 data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system)	Warning	H373	P260 P314 P501	In 3-month oral administration tests using rats (0, 0.1, 0.5, 2.5 and 12.5 mg/kg/day), no exposure-related toxic effects were detected, and NOEL was found to be >= 12.5 mg/kg/day (IRIS (2002)). On the other hand, in 3-month oral administration tests using rats (0, 0.15, 1.5, 15 and 30 mg/kg-day), occurrence of tremors was detected during the fifth week after administration, and the symptom disappeared by Week 11 in female rats in the highest dose groups (30 mg/kg/day) (IRIS (2002)); and in 13-week oral administration tests using dogs (doses: 0, 250, 500 and 750 ppm (conversion values: 0, 6.25, 12.5 and 18.75 mg/kg bw/day)), occurrence of ataxia, tremors, lethargy and panting was observed. In particular, because tremors (IRIS (2002)) were detected at the dosage group equivalent to Category 2 guidance values (18.75 mg/kg bw /day), the substance was classified into Category 2 (nervous system). As relevant notes, in 13-week oral administration tests using dogs, low values were found in blood examination parameters (hematocrits, hemoglobin, and erythrocytes); and in inhalation tests using rats (no record of exposure time available), normocytic anemia, change in blood composition (e.g., TP, bilirubin, and cholesterol), and change in cholinesterase were documented (RTECS (2007)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 48-hour EC50 = 0.00053 mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Its classification for acute toxicity is Category 1 and it is not rapidly degradable (based on an estimated rapid degradability by BIOWIN), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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