NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	420-04-2
Chemical Name	Cyanamide
Substance ID	m-nite-420-04-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	There is the information that it is combustible at increased temperature (ICSC (J) (2007)), but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (aminonitriles) in the molecule, but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	There is the information that it is a substance with melting point of <= 55 deg C and is corrosive to metals (steel, copper, aluminum, etc.) (ICSC (J) (2007)), but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on reports of LD50 values for rats of 100-125 mg/kg (male) (DFGOT vol. 24 (2007)), 125 mg/kg (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on June 2017)), 223 mg/kg (DFGOT vol. 24 (2007)), and 280 mg/kg (HSDB (Access on June 2017)), it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on reports of LD50 values for rabbits of 590 mg/kg (HSDB (Access on June 2017)), 742 mg/kg (female), and 901 mg/kg (male) (both DFGOT vol. 24 (2007)), it was classified in Category 3. The category was changed from the previous classification by using new information sources.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is a report of an LC50 value of > 1.0 mg/L in a 4-hour inhalation exposure test with rats (DFGOT vol. 24 (2007)). However, since it was not possible to identify a category from this value alone, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on a description of strong irritation of the skin in humans (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011)) and on a report that in a skin irritation test with rabbits, slight to moderate erythema and slight to severe oedema were produced on the intact skin (DFGOT vol. 24 (2007)), it was classified in Category 2. Besides, this substance was classified as Skin Irrit. 2 in EU CLP classification (ECHA CL Inventory (Access on June 2017)). Based on the information obtained in this survey, the category was revised.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on a description of irritation of the eyes in humans, and on a report that in an eye irritation test with rabbits, moderate to severe irritation (redness, swelling of the conjunctiva, corneal opacity) was observed and this did not resolve within one week in some cases, it was classified in Category 2A. Besides, this substance was classified as Eye Irrit. 2 in EU CLP classification (ECHA CL Inventory (Access on June 2017)). Based on the information obtained in this survey, the category was revised.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In a maximization test with guinea pigs, intradermal injection and induction with a 10% aqueous solution of this substance and petrolatum containing 5% of this substance were performed, and a challenge with petrolatum containing 2.5% of this substance on Day 21 was performed. As a result, the positive rate was 100% 24 and 48 hours after the application (DFGOT vol. 24 (2007)). In addition, there is a description that repeated or prolonged contacts may cause skin sensitization in humans (HSDB (Access on June 2017)). From the above, it was classified in Category 1. Besides, there is a description that in grapevine producers handling this substance without wearing protective equipment, among four persons in whom strong skin effects were observed, skin damage like erythema multiforme in two persons and skin damage like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in the other two occurred (HSDB (Access on June 2017)). This substance was classified as Skin Sens. 1 in EU CLP classification (ECHA CL Inventory (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, micronucleus tests with mouse bone marrow cells were negative (DFGOT vol. 24 (2007)). As for in vitro, bacterial reverse mutation tests were negative (DFGOT vol. 24 (2007)). From the above, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government. The category was changed because the information source in the previous classification (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2002)) was not able to be confirmed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	In a 2-year carcinogenicity study with mice dosed by drinking water, an increasing tendency of tumors of the granulosa and theca cells in the ovary was observed, but similar findings were also observed in 3/60 of the control group. However, when one of these cases was excluded because of a suspicious finding, a statistically significant increase (8/58 cases) at the highest dose (600 mg/L) was shown. The original authors did not describe the increase in tumors in the high dose group as effects of administration, based on the fact that the finding in one case of a control group was questionable with regard to an increase in tumors of the granulosa and theca cells in the ovary, and it was stated that further investigation was required (DFGOT vol. 24 (2007)). From the above, it is difficult to say that ovary tumors in mice constitute clear evidence for carcinogenicity due to the administration of this substance, and there is no other information on carcinogenicity of this substance. Therefore, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a two-generation study with rats dosed by gavage, decreased body weight gain, a decrease in the number of corpora lutea, implantations, and offspring, and decreased fertility rate were observed in F0 females at 25 mg/kg/day (DFGOT vol. 24 (2007), Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), PATTY (6th, 2012)). In F0 males, a decrease in the relative weight of the epididymis, testicular atrophy, and absence of sperm in the epididymal tubules were observed at 25 mg/kg/day (DFGOT vol. 24 (2007)). In F1, effects on developmental indexes including opening failure of the auricle and descent failure of the testes were observed at 25 mg/kg/day. Besides, in order to examine whether a cause of decreased fertility rate was in females or males, females and males which were dosed at 25 mg/kg/day were mated with untreated females and males. As a result, decreased fertility rate was indicated when treated males were mated with untreated females, but no effect on a fertility rate was observed when treated females were mated with untreated males (DFGOT vol. 24 (2007)). From the above, effects on the male genetic organs and on development in pups, in addition to decreased fertility rate, were observed at the dose where decreased body weight gain in F0 females was observed. Therefore, it was classified in Category 2. Besides, in this review, since the information available for classification was obtained from the information source in List 1, the classification became possible.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	There is a report that in a single oral administration test with rats, at 150 mg/kg/day corresponding to Category 1, lethargy, tremor, crouching position, ataxia and piloerection, and at higher doses, in addition to these symptoms, abnormal gait, abdominal position, labored breathing and bloody lacrimation were shown, and at necropsy, pulmonary hemorrhage and pleural effusion were observed (DFGOT vol. 24 (2007)). In addition, there is a report that in a single inhalation test in which rats were exposed to an aerosol of this substance, at a 4-hour inhalation exposure at 1 mg/L, closed eyes, shallow breathing, and frequent coughing and swallowing reaction were shown, but these resolved several hours after the end of exposure (DFGOT vol. 24 (2007)). From the above, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation). The classification result was changed from the previous classification by using the new information source. Besides, there is a description that since this substance inhibits aldehyde dehydrogenase, it is used as an alcohol consumption inhibitor in humans, and after ingesting alcohol (and foods containing alcohol, etc.) after oral ingestion of this substance, facial flushing, blood pressure reduction, nausea, tachycardia, dizziness, dyspnea, and decreased visual acuity may occur (Ethical Pharmaceuticals 2017 (2016)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system, thyroid, liver, reproductive organs (male))	Danger	H372	P260 P264 P270 P314 P501	As for humans, there is a description that since this substance inhibits aldehyde dehydrogenase, it is used as an alcohol consumption inhibitor, and it is usually administered at 50-200 mg per day in alcohol abstinence therapy, and at 15-60 mg per day in alcohol sobriety therapy, and as side effects, effects on the skin, blood, and liver are pointed out (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011)), and there are reports that in patients who used this substance as an alcohol aversion medication, ground-glass like hepatitis, which was not seen before the treatment, was seen after the treatment (PATTY (6th, 2012), DFGOT vol. 24 (2007)). As for experimental animals, in a 28-day repeated oral dose toxicity test with rats given by gavage, bile duct hyperplasia of the liver, decreased colloid of the thyroid follicles at or above 10 mg/kg/day (converted guidance value: 3.11 mg/kg/day) within a guidance value range for Category 1, decreased body weight gain and increased liver weight at 20 mg/kg/day or above (converted guidance value: 6.22 mg/kg/day), and a decrease in the erythrocyte count, hemoglobin concentration and hematocrit value, an increase in weight of the thyroid and parathyroid, and hyperplasia of the thyroid follicular cells, etc. were observed at 40 mg/kg/day (converted guidance value: 12.44 mg/kg/day) within the guidance value range for Category 2. In a 90-day repeated oral dose toxicity test with rats given by feeding, an increase in the solid and small thyroid follicle and increased incidence of proliferation of the follicular epithelial cells and parafollicular epithelial cells at 1.5 mg/kg/day or above within the guidance value range for Category 1, and an increase in the erythrocyte count and relative liver weight, decreased thymus relative weight at 4.5 mg/kg/day were observed (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), DFGOT vol. 24 (2007)). In addition, in a 90-day repeated oral dose toxicity test with dogs given by gavage, decreased testes weight, atrophy of the testicular tubules, decreased spermatogenesis, and an decrease in the number of spermatocytes in the epididymis at or above 0.6 mg/kg/day within the guidance value range for Category 1, an decrease in T4 value and AST, increased ALT, and increased mononuclear leukocyte count at 2 mg/kg/day or above, and decreased body weight gain and an decrease in the hemoglobin concentration and hematocrit value at 6 mg/kg/day were observed (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), DFGOT vol. 24 (2007)). From the above, it was classified in Category 1 (haemal system, thyroid, liver, genetic organs (men)). Since the new information sources were used, the classification result was different from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 72-hour EC50 (biomass) = 0.37 mg/L for algae (Anabaena flosaquae) (EPA AQUIRE: 2017, Pesticide Ecotoxicity Database (1992)), it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (non-biodegradable, average degradation rate by BOD: 0% (J-CHECK, 2012)), and 21-day NOEC (body length) = 0.1 mg/L for crustacea (Daphnia magna) (EPA AQUIRE: 2017, Pesticide Ecotoxicity Database (1992)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (non-biodegradable, average degradation rate by BOD: 0% (J-CHECK, 2012)), and 72-hour EC50 (biomass) = 0.37 mg/L for algae (Anabaena flosaquae) (EPA AQUIRE: 2017, Pesticide Ecotoxicity Database (1992)). From the above results, it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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