NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	446-35-5
Chemical Name	2,4-Difluoro-1-nitrobenzene
Substance ID	m-nite-446-35-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	Although there is a chemical group associated with explosive properties (nitro group) in the molecule, and oxygen balance of -116 is above the criteria, -200, the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Based on a flash point data of 91 deg C (closed cup) (Sigma-Aldrich (2017)), it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule, but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 480 deg C (BUA 252 (2004)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an organic compound which does not contain chlorine but contains fluorine and oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on reports of LD50 values for rats of 194 mg/kg and 200 mg/kg (BUA 252 (2004)), it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	There is a report of an LD50 value for rats of 84 mg/kg (BUA 252 (2004)), and it corresponds to Category 2. There is a report of an LD50 value for rabbits of 207 mg/kg (BUA 252 (2004)), and it corresponds to Category 3. It was classified in Category 2 by adopting the category with higher hazard.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There is a report that in an 8-hour inhalation exposure test with rats, no death occurred at about 1.78 mg/L (274 ppm) (converted 4-hour equivalent value: 2.52 mg/L (387 ppm)) (BUA 252 (2004)), however, since it is not possible to specify the category only with this data, it was classified as "Classification not possible." Besides, since the exposure concentration is lower than 90% of the saturated vapor pressure concentration (2.17 mg/L (335 ppm)), a reference value in the unit of ppm was applied as vapor with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, this substance has high dermal toxicity, and in a skin irritation test with rabbits, animals died on an application of an undiluted solution. There is a report that as 1 mL of an undiluted solution was washed 15 minutes after application, no irritation was shown in a 14-day observation (BUA 252 (2004)). However, it was not adopted because the experimental conditions were insufficient.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	In an eye irritation test with rabbits (OECD TG 405-compliant), no effect was observed on the cornea and iris, and redness of score 2 and edema of score 1 were observed 1 hour after an application to the conjunctiva. However, they decreased after 2 days, and the irritation score (MMAS) was 4.7 (ECETOC TR48 (1998)). Similarly, there is a description that in an eye irritation test with rabbits, the irritation scores after 1, 7, 24, 48, 72 hours were 5, 2, 14, 10, 11, respectively, and slight irritation was observed (BUA 252 (2004)). On the other hand, it is also described that it was not irritating to the eyes (BUA 252 (2004)), therefore, it was classified as "Classification not possible." The category was changed by reviewing information.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	There is a report that, in order to investigate the delayed type hypersensitivity skin reaction, this substance was applied to 96 volunteers, and challenge treatments were done to 30 people whose skin reaction disappeared after the introduction, and as the result, positive responses were observed in 27 of them (90%) (BUA 252 (2004)). However, the details of the results of the control group etc. are unknown, and it is not possible to conclude that this substance is positive based on this result, therefore, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system, blood system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	There is no information on single exposure to this substance in humans. As for experimental animals, there is a report that in a single oral dose test with rats, the methemoglobin concentration in the blood rose up to a maximum 6% at a dose of 80 mg/kg, and it decreased to less than 2% after 48 hours (BUA 252 (2004)). In addition, there are reports that in other two single oral dose tests with rats, staggering gait, crouching position, ventral or lateral position, convulsions, tremors and lacrimation were observed. Although there is no detailed description of the dosage at which these effects were observed, it is considered to be in the range for Category 1 near the LD50 values of 197 mg/kg and 200 mg/kg (BUA 252 (2004)). Moreover, there is a report that in a single oral administration in cats at 100 mg/kg, the methemoglobin concentration in the blood rose up to 8.5 to 11%; Heinz body formation and blue discoloration of the tongue were observed: they showed muscle tremors, twitching, salivation, and gasping and died within 2 hours (BUA 252 (2004)). As for the dermal route, there is a report that in a single dermal exposure test with rabbits, disturbance of the equilibrium sense, muscle tremor, twitch were observed at or above 160 mg/kg; cyanosis, an increased respiration rate, and yellow urine were observed at or above at or above 200 mg/kg (BUA 252 (2004)). Additionally, in a single dermal exposure test with rats, they showed a crouching or prone position, tremors, and convulsions and died after 2 hours to 2 days. Although there is no detailed description of the dosage at which these effects were observed, it is considered to be in the range for Category 1 near the LD50 value of 84 mg/kg (BUA 252 (2004)). By summarizing the above information, the target organs of this substance are considered to be the nervous system and haemal system. The effects on experimental animals are all observed at dosages within the range for Category 1. They correspond to Category 1 from the guidance value, however, it is the data from BUA which are an information source in List 2, and it does not satisfy the criterion 1b3) (OECDTG test and GLP compliance test). Therefore, it was classified in Category 2 (nervous system, haemal system) according to the GHS classification guidance for the Japanese government. The classification result was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 96-hour LC50 = 7.1 mg/L for fish (Danio rerio) (BUA vol.252: 2004), it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Chronic toxicity data were not obtained. Due to being not rapidly degradable (BioWin), and acute toxicity Category 2, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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