NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	4979-32-2
Chemical Name	N,N-Dicyclohexan-1-yl(1,3-benzothiazol-2-ylsulfanyl)amine
Substance ID	m-nite-4979-32-2_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It is an organic compound not containing oxygen, fluorine or chlorine.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Although in the Health, Labor and Welfare Ministry reports (Access on October 2008), LD0 values of the oral administration test (OECD TG 401, GLP) employing a rat were 1,821 mg/kg (male) and 1,077 mg/kg (female), the dose correlation was not found. However, LD50 values are estimated to be >= 1,821 mg/kg (male) and >= 1,077 mg/kg (female). Moreover, LD50 value >5,000 mg/kg and 6,420 mg/kg of the oral administration test employing a rat are shown in SIDS (2004). Furthermore, Patty (5th, 2001) describes that "LD50 value of acute toxicity (oral) is >5,000 mg/kg." . As mentioned above, LD50 value 6,420 mg/kg that was a definite value was adopted, and it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From a description of LD50 value of >2,000 mg/kg (SIDS (2004), Patty (5th, 2001), IUCLID (2000)) in the dermal administration test employing rabbits, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Although there is a description, "moderate skin irritation" (SIDS (2004))in the 24 hour Draize test using rabbits, classification is not possible, because it is the result under a severer condition than 4 hours.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	SIDS (2004) has described as "Not irritating" in the eye irritation test employing rabbits and as "slightly" in Draize test. As a conclusion, since SIDS (2004) has described as "slightly irritating to eyes in rabbits", it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	There is no data about humans. There is a description of "Not sensitizing" in the Maximization tests employing guinea pig (SIDS (2004), IUCLID (2000)), and it has been concluded that "there is no skin sensitizations" in SIDS (2004). Moreover, it was classified into "Not classified" since it has been concluded that "this substance is not a skin sensitizer" in Patty (5th, 2001) as well.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Since there is a description that the body cell in vivo mutagenicity test (chromosome aberration test (GLP) employing rats bone marrow cell) was "negative" (SIDS (2004)), it was carried "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is a conclusion that "there is no research example with sufficient evidence" (SIDS (2004), Patty (5th, 2001), IUCLID (2000)), classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	It is reported in a Ministry of Health, Labor and Welfare Report (Access on October 2008), SIDS (2004) that in a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422, GLP), "no changes in the rates of copulation and conception were observed, and it was judged that there were no effects." Moreover, for effects on fetuses and neonates and abnormalities in delivery and rearing at doses at which toxicities manifest themselves in mother animals, it is reported that "general toxicological effects are thought to be the greatest." However, in this study the data on teratogenicity in the offspring is insufficient. Since there is no other experimental data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In the acute oral toxicity test employing a rat (OECD TG 401, GLP), "As symptoms, diminished locomotor activity, deep respiration, nerve tremor, spasm, etc., were observed. There is a description that these symptoms has recovered in the living animal on and after 7th day."(Health, Labor and Welfare Ministry reports (Access on October 2008)). Since this effect was seen within the range of the guidance value of Category 2, it was classified into Category 2 (central nervous system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney, adrenal gland, thymus, central nervous system, respiratory system)	Warning	H373	P260 P314 P501	It is written in the combination test of repeated dose toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that there was PAS positive hyaline droplet in proximal tubular epithelium of the kidney in males, and enlargement and fading of the kidney ,fatty degeneration of proximal tubular epithelium of the kidney, enlargement and fading of the adrenal gland, tabefaction, and decrease in locomotor activity in females, in addition, thymic atrophy in males and females"" (Ministry of Health, Labour and Welfare reports (Access on October 2008)). These effects were found within the scope of the guidance value of Category 2. Moreover, it is written in repeated inhalation exposure test in rats that "the irritation to mucosa is caused" (SIDS (2004)), and this effect was found within the scope of the guidance value of Category 2. Therefore, it was classified into Category 2 (kidney, adrenal gland, thymus, central nervous system, and respiratory system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 72-hour ErC50 > 0.012 mg/L for algae (Raphidocelis subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013, SIAR, 2004), 48-hour EC50 > 0.031 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013), and 96-hour LC50 > 0.033 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 4	- -	H413	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1995)), 72-hour NOErC >= 0.0118 mg/L for algae (Raphidocelis subcapitata) (SIAR, 2004), and 21-day NOEC > 0.033 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (fish), this substance is water-insoluble (water solubility = 0.0019 mg/L, SIAR, 2004), and 96-hour LC50 for fish (Oryzias latipes) is > 0.033 mg/L (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013), but it is classified in Category 4 because it is not rapidly degradable and is bioaccumulative (BCF =3380-7310 (Fish bioconcentration test, 0.1-0.01 microg/L district (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 2001). By drawing a comparison between the above results, it was classified in Category 4.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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