NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	50926-11-9
Chemical Name	Indium tin oxide
Substance ID	m-nite-50926-11-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (HSDB (Access on May 2016)) .	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (HSDB (Access on May 2016)) .	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (HSDB (Access on May 2016)) .	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water due to the observation result of being insoluble in water (HSDB (Access on May 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	The LD50 value of > 10,000 mg/kg (PATTY (6th, 2012)) for rats is reported for indium oxide. Indium tin oxide is a mixture of indium oxide and tin oxide, and LD50 values of these compounds are both 2,000 mg/kg or above, therefore, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on the description that this substance may cause severe irritation to the skin (HSDB (Access on June 2016)), this substance was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on the description that this substance may cause severe irritation to the eyes (HSDB (Access on June 2016)), this substance was classified in Category 2A.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　As for in vivo, in the intratracheal administration test of this substance (ITO particles) on rats, a significant increase in micronuclei frequency was observed. 　However, as for the in vitro test, an increase in the micronuclei frequency in the alveolar epithelial cells by this substance (ITO particles) was not observed, and therefore, it is evaluated that the result of the in vivo test is due to a secondary genotoxic mechanism (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013), HSDB (Access on May 2016)). There is no other information.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	There is no information on carcinogenicity to humans. 　As for experimental animals, in a carcinogenicity study using rats or mice exposed by inhalation to indium tin oxide (ITO) containing 90.06% of indium oxide and 9.74% of tin oxide at a concentration of 0.01 - 0.1 mg/m3 for 2 years (26 weeks only for rats in a high concentration group due to lung injury), neoplastic change was not observed in the mice, but as for the rats, increase in the incidences of pulmonary tumors including bronchiolar-alveolar adenomas and carcinomas were observed in both sexes (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). As for classifications by other organizations, the Japan Society for Occupational Health has classified hardly soluble inorganic indium compounds in Group 2A (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2015)). Therefore, this substance was classified in Category 1B for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, it is described in Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013) that indium irritates the respiratory tract, but it was quoted from ICSC, and the original literature could not be confirmed. Also, it is not clear whether the descriptions on only metallic indium or a description of indium compounds in general.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	As for humans, as a case report, there is a report of interstitial pneumonia in workers involved in grinding process of indium tin compounds (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), OEL Documentations (Japan Society For Occupational Health (JSOH), 2007)). 　In Japan, there are case reports of interstitial pneumonia and fibrosis in workers at an indium tin oxide (ITO) production/processing factory, indium recycling factory, indium oxide manufacturing factory, and investigation report indicating an increase in KL-6 value, SP-D value and SP-A value which are indicators of interstitial pneumonia. Also, it has been revealed that lung disease, mainly interstitial pneumonia occurs due to exposure to ITO or indium oxide. Also, there are case reports that alveolar proteinosis occurs in workers at ITO manufacturing plants in the United States as well (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013)). 　As for experimental animals, in a 13-week study using rats exposed by inhalation, effects on the lungs (pulmonary alveolar proteinosis, granuloma of the lymph nodes of the lung, hyperplasia of the alveolar epithelium, etc.) were observed within the range of Category 1. In addition, in a 104-week inhalation exposure study, bronchiolar/alveolar hyperplasia, fibrosis of the alveolar wall in the lung, pleural thickening, granuloma of the para-bronchial lymphoid tissue and granulomas in the mediastinal lymph nodes, etc. were observed in the range of Category 1. In a 13-week study using mice exposed by inhalation, in addition to the influence on the lung (alveolar proteinosis, infiltration of inflammatory cells, hyperplasia of mediastinal lymph nodes, etc.), increases in red blood cell count, hemoglobin concentration, and hematocrit value and extramedullary hematopoiesis of the spleen, etc. were observed at within the range of Category 1. Moreover, in a 104-week study exposed by inhalation, pleural thickening, hyperplasia of mediastinal lymph nodes, hyperplasia of para-bronchial lymph tissue, etc. were observed as effects on the lungs within the range of Category 1 (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013). 　Of the above, hematological findings and effects on the hematopoietic system were not adopted as evidence of classification because it is considered that they may be adaptive response to lack of oxygen due to respiratory effects. Also, in the previous classification, in ACGIH (7th, 2001), based on the description that "For indium and its compounds, TLV-TWA is set up by the influence to the skeleton and gastrointestinal system and hazardous properties especially by the inhalation to the lungs," etc., skeletal and digestive system as well as respiratory organs were determined as target organs. However, this is based on a preliminary investigation on exposure to indium compounds by the EPA, and because it is a preliminary survey, and its reliability is considered to be low due to no information other than symptom names based on complaints, etc., it was not adopted as evidence of the classification. Therefore, this substance was classified in Category 1 (respiratory organs).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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