NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	51-28-5
Chemical Name	2,4-Dinitrophenol
Substance ID	m-nite-51-28-5_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Division 1.1	Danger	H201	P370+P372+P380+P373 P210 P230 P234 P240 P250 P280 P401 P501	The substance contains nitro groups, with its oxygen budget calculated at -78. The kick-off temperature is 189degC, while the decomposition energy is 144kJ/g (Bretherick (J) (5th,1998)), which is classified as "Explosive." Classified as Division 1.1 since the substance is assigned to Division 1.1D (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) by the UN Recommendations on the Transport of Dangerous Goods.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Classification not possible due to lack of data, though flammable according to ICSC (2004). Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Classified as "explosives". Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available (melting point: 112degC (ICSC, 2004), test temperature: 140degC).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified	- -	-	-	Organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	The substance is classified into Category 2 from the viewpoint of safety, based on the description in the report on guinea pig skin irritation tests (ATSDR (1995)): "moderately irritating," though the results of rabbit skin irritation tests suggest the substance is "mildly irritating" (CERI Hazard Data 99-9 (2000)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to the insufficiency of data	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in .ATSDR (1995) and NTP DB (Access on April 2006).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible based on expert judgment in the absence of existing classification, though ATSDR (1995) presents some toxicity data.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Based on the evidence of significant increases in the number of pups stillborn or dying during lactation observed in rat teratogenic studies, described in MOE Risk Assessment vol. 3 (2004) and ATSDR (1995), though no data are available on parental toxicity.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Based on the evidence from animal studies: "crawling observed in both sexes" (Report by the Ministry of Health, Labour and Welfare (2001)), "displayed very mild tubular necrosis" (ATSDR (1995)).The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (cardiovascular system, blood system, visual organs, nervous system, kidney, liver, gastrointestinal tract), Category 2 (testis)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Based on the human evidence: "blood effects including hemolytic anemia, neutropenia and eosinophilia were detected as key effects following exposure to 2,4-denitrophenol" (CERI Hazard Data 99-9 (2000)), "over 100 anecdotal cases of cataracts resulting from therapeutic use of 2,4- dinitrophenol were reviewed" (IRIS (1987)), "necrosis of hepatocytes and hemorrhage were found in the liver; destruction of the epithelium lining the renal tubules with hemorrhage into the glomeruli was found in the kidneys; myocarditis was considered to be the cause of death," "the small intestine contained numerous focal hemorrhagic necroses, severe fatty changes and hemorrhagic nephritis were found; the patient complained of weakness and malaise, became delirious and occasionally euphoric, and showed diminished knee-jerk reflex; a fatal case of agranulocytosis occurred" (ATSDR (1995)). Also based on the evidence from animal studies including "pathological changes in the liver and kidneys, and testicular atrophy were noted" (CERI Hazard Data 99-9 (2000)), "reduced locomotor activity, salivation and calcification of the renal cortico-medullary junctions were observed" (MOE Risk Assessment vol. 3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.09 mg/L for fish (Oncorhynchus mykiss) (ECETOC TR91, 2003).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 because it was not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Official Bulletin of Ministry of International Trade and Industry, 1989)), and due to 60-day NOEC = 0.023 mg/L for fish (Cirrhinus mrigala) (Environmental Risk Assessment for Chemical Substances Vol. 16 (Ministry of the Environment, 2018)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because it was not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Official Bulletin of Ministry of International Trade and Industry, 1989)), and due to 96-hour EC50 = 2.6 mg/L for algae (Pseudokirchneriella subcapitata) (Environmental Risk Assessment for Chemical Substances Vol. 16 (Ministry of the Environment, 2018)). By drawing a comparison between the above results, it was classified in Category 1.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information