Item | Information |
---|---|
CAS RN | 513-35-9 |
Chemical Name | 2-Methyl-2-butene |
Substance ID | m-nite-513-35-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Classified into Category 2 since flash point -45 degC (closed-cup) (IUCLID (2000)) is <23 degC and initial boiling point 38.56 degC (Lide (88th, 2008)) is >35 degC. The substance is classified into Class 3, PG II in UNRTDG (UN2460). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | Classified into Type G since the substance is considered not to fall into upper Division 4.1 "Self-reactive substances and mixtures" from which it contains a stabilizer (p-tert- Butylcatechol (SIDS (2004)) and is classified into Class 3, PG II in UNRTDG (UN2460) though there are chemical groups (unsaturated bond) present in the molecule associated with self-reactive properties. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Auto-ignition point is 275 degC (Lange (16th, 2005)) exceeding 70 degC. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to liquid (low boiling point) substances are not available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on a LD50 value of 1000 - 1700 mg/kg for rats (GLP) (SIDS (2004)), the substance was classified into Category 4. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a LD50 value of >2000 mg/kg bw for rats (GLP) (SIDS (2004)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified |
- |
- | - | Based on a LC50 value of >61000 ppm/4h (6.1% (v/v) (175 mg/L) for rats (GLP) (SIDS (2004)), the substance was classified as "Not classified". Since saturated vapour pressure concentration is 605,263 ppm, the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas was adopted. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on a result of "slightly irritating" with PDII (1.79) in a rabbit Draize test (GLP) where 0.5 mL of the substance was applied to the skin for 24-hour (SIDS (2004)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | Based on a result of "not irritating" with Draize score of 0 at 24, 48 and 72-hour after application in a rabbit eye irritation test (GLP) (SIDS (2004)), the substance was classified as "Not classified". | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Not classified |
- |
- | - | Based on a result of not sensitizing (positive ratio: 0%, 0/20 animals) in a guinea pig maximization test (GLP) (SIDS (2004)), the substance was classified as "Not classified". | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
Based on positive results in an inhalation rat and a mouse erythrocyte micronucleus test (in vivo somatic cell mutagenicity tests) (SIDS (2004)), the substance was classified into Category 2. As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (SIDS (2004)) and a negative rat liver cell chromosome aberration test (IUCLID (2002)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a combined repeat dose and reproductive/developmental screening rat inhalation test (OECD 422 (GLP)), the estrus cycle was unaffected by exposure, mating performance and fertility indices were similar in all groups. There were no adverse effects upon survival or growth of the offspring in utero or up to day 4 of lactation. Additionally, no evidence of reproductive or developmental toxicity was seen (SIDS (2004)). However, classification was not possible due to lack of data since this screening test did not contain prenatal fetal examination resulting in no data for teratogenicity. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
In a rat inhalation test (vapour) (GLP) there were no deaths and macroscopic and microscopic examination at necropsy after exposure was terminated revealed no compound related effects at 61000 ppm/4h. The animals became narcotized but revived within 30 minutes of cessation of exposure (SIDS (2004)). Additionally, there is a report of lethargic as a sign after oral administration to rats (SIDS (2004)). Therefore, the substance was classified into Category 3 (narcotic effects). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a combined repeat dose and reproductive/developmental test (OECD 422 (GLP)) where rats were exposed via inhalation (vapour) for 28 days, decreased incidence of extramedullary haemopoiesis of the spleen, increased globlet cell hyperplasia in the nasal passages of males and minimal centrilobular hepatocyte hypertrophy in the liver of females were noted at a dose level of 7000 ppm/6h (20 mg/L/6h) (90-day equivalence: 6.25 mg/L/6h) which exceeds the guidance value range of Category 2 (<=1.0 mg/L/6 hr). In the 2000 ppm (5.2 mg/L/6h) (90-day equivalence: 1.6 mg/L/6h) dosed males, a slight increase in severity of myocardial inflammatory heart lesions and cortical/medullary tubular basophilia in the kidneys were observed (SIDS (2004)). Classification was not possible due to lack of data for evidence of effects near the upper limit guidance value range of Category 2. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
Classified into Category 2 from its 96h-LC50 = 1.99 mg/L for fish (Rainbow trout) (SIDS, 2004). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (SIDS, 2004). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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