Item | Information |
---|---|
CAS RN | 513-77-9 |
Chemical Name | Barium carbonate |
Substance ID | m-nite-513-77-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because data of water solubility: 0.002 g/100 mL (20 deg C) (ICSC (2006)) were obtained, it is estimated that it does not react vigorously in contact with water. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
In addition to 3 reports of LD50 values for rats of 418 mg/kg (SIDS (2006), EHC 107 (1990)), 800 mg/kg (EHC 107 (1990)) and 118-800 mg/kg (CICAD 33 (2001)), there is a report of the lowest oral lethal dose in humans of 57 mg/kg (CICAD 33 (2001)). Based on the data in humans, it was classified in Category 3. Instead of a low priority information source (RTECS (2004)), new information sources (SIDS (2006), CICAD 33 (2001)) were added, and the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" since barium and its soluble compounds are classified in A4 by ACGIH (7th, 2001). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. In the previous classification, on the basis that effects on spermatogenesis/oogenesis and on other effects on testis/ovary were observed by inhalation administration to male and female rats (EHC 107 (1990), CICAD 33 (2001)), and that lethal toxicity in fetuses was observed by oral administration to pregnant rats (EHC 107 (1990)), it was classified in Category 2. However, regarding "Tarasenko, NY, Pronin, OA, and Silayev, AA (1977) Barium compounds as industrial poisons (an experimental study), J. Hyg. Epidemiol. Microbiol. Immunol., 21, 361-373" which is the original source of these data, it is stated in ATSDR (2007) that since the study design and reporting were insufficient, and the incidence data or statistical analysis were not described in the published literature, it was not possible to properly evaluate the study results. In addition, SIDS (2006) also did not use these data for evaluation because the reliability could not be evaluated. Therefore, in reviewing the classification, these data were not used for the classification as were considered unreliable. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, cardiovascular system, muscular system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance is irritating to the respiratory tract. In humans there are multiple case reports, in which vomiting, intense abdominal pain, gastrointestinal tract disorders with diarrhea, arrhythmia, elevated blood pressure, loss of tendon reflexes, mydriasis and drowsiness were observed in common with accidental cases, suicide cases and exposure of workers by oral ingestion. Muscle weakness and paralysis of the limbs and necks were reported on acute inhalation of workers to the dust. In addition, it strongly stimulated the striated muscle, cardiac muscle and smooth muscle, and neuromuscular blockade due to a decrease in serum potassium to cause muscle weakness. In multiple cases, high doses caused significant effects on the beating and rhythm of the heart, and ventricular tachycardia, impaired cardiac automaticity, ventricular fibrillation and cardiac arrest occurred. In the intentional or accidental oral ingestion, gastrointestinal disorders (vomiting, diarrhea, abdominal pain), hypokalemia, hypertension, arrhythmia, muscle weakness, skeletal muscle paralysis, flaccid paralysis, and paresthesia were reported (SIDS (2006), ACGIH (7th, 2001), ATSDR (2007), CICAD 33 (2001), EHC 107 (1990), HSDB (Access on August 2014)). In experimental animals, by oral administration (concentration, etc. not described), salivation, nausea, diarrhea, tachycardia, hypokalemia, hypotension, spasms, skeletal muscle relaxation paralysis, respiratory muscle paralysis, and ventricular fibrillation were reported (SIDS (2006), ATSDR (2007), EHC 107 (1990)). From the above, it was classified in Category 1 (nervous system, cardiovascular system, muscular system), Category 3 (respiratory tract irritation). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system, nervous system, muscular system, kidney) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is a description that elevated blood pressure in 3 out of 12 workers chronically exposed to the dust of this substance and abnormalities on their electrocardiograms were observed in 2. However, since comparison with the incidence in an unexposed population was not possible, it was not possible to clarify the relationship between exposure to this substance and the increased incidence of cardiovascular disorders (ATSDR (2007)). In addition, while there are two reports of development of pneumonoconiosis in workers chronically exposed to the dust of barium sulfate, there is one report that in workers exposed to this substance, no respiratory symptoms due to barium exposure and no abnormalities in the lung on the X-ray examination were observed (ATSDR (2007)). In experimental animals, there are reports that in studies in which rats were exposed by inhalation to the dust of this substance for 1 or 4 months, at a dose corresponding to Category 1 (converted guidance value: 0.0035 mg/L/6 hours), effects on the respiratory organs, etc. were observed. However, in these studies, since the test items are limited, and descriptions are inadequate, this test is also considered to have an uncertain reliability (SIDS (2006)), and it was considered insufficient data for classification. Therefore, the target organ cannot be identified by the inhalation route. On the other hand, since there is a description that this substance is an acid-soluble barium compound and is absorbed through the gastrointestinal tract after oral ingestion (ATSDR (2007)), it is considered that barium carbonate may cause target organ toxicity similar to that of water-soluble barium chloride (CAS RN 10361-37-2) by the oral route. Therefore, it was classified in Category 1 (cardiovascular system, nervous system, muscular system, kidney). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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