NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	5131-66-8
Chemical Name	3-butoxypropan-2-ol; propylene glycol monobutyl ether
Substance ID	m-nite-5131-66-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since its flash point is 63degC (ICSC (2005), ICSC (J) (2005)), the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Its autoignition point is 260degC (ICSC (2005), ICSC (J) (2005)), which is >= 70degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Excluding results from secondary documents, the rat LD50 values obtained were 3300mg/kg (OECD TG 401), 1900mg/kg, and 2500mg/kg (SIDS, accessed July 2008). Two of the three LD50 values fell into the "Not classified" category, and one of them resulted from a test that was compliant with OECD TG 401 and thus is a most reliable value. Based on this LD50 value, the substance was classified into "Not classified" (this classification was based on JIS criteria, while the substance is in Category 5 based on the United Nations GHS classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	The following LD50 values have been documented for this substance: > 2000mg/kg (OECD TG 401) and 2640mg/kg for rats, > 2000mg/kg, 3133mg/kg, 3100mg/kg, and 1400mg/kg for rabbits (SIDS, accessed in July 2008). The substance was classified into "Not classified" because all of the LD50 values listed above, except for one rabbit valuefor, fell within the range of "Not classified" guidance values.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	It has been documented that its rat LC50 values were > 3.52mg/L/4h and > 5.83mg/L/8h (equivalent to > 7.04mg/L/4h) (its saturated vapour pressure is 9.97mg/L). However, mortality was not observed among the treated animals in these tests (SIDS, accessed in July 2008). Consequently, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Its classification was based on skin irritation tests using rabbits (OECD TG 404) in which applications of undiluted and 75% solutions for 4 hour resulted in the primary skin irritation index values of 4.0 and 2.5, leading to the conclusion that the substance was moderately irritating (SIDS (2000)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	The tests in which the undiluted substance was applied into the eyes of rabbits (OECD guidelines 405) resulted in observations of mild corneal clouding (score: 0), edemas of iris veins (score: 0.2), occasional marked chemosis of the conjunctiva (score: 2.2), and redness (score: 1.0), which led to conclude that the substance was moderately irritating (SIDS (accessed July 2008)). However, since these symptoms disappeared within 7 days (SIDS (accessed July 2008), it was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	In a skin sensitization test using guinea pigs (Buehler test: OCD guidelines 406), the substance was not sensitizing to skin by challenge (SIDS, accessed July 2008). Based on this result, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Negative results have been obtained from in vitro mutagenicity tests (Ames tests, chromosomal aberration tests, and mouse lymphoma tests) (SIDS, accessed July 2008). However, since there was no data from in vivo tests, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	No toxicity of this substance was observed in terms of general toxicity in maternal animals, fetotoxicity, and teratogenic effects, in tests using rats and rabbits that underwent dermal administration during the organogenetic period (SIDS (accessed in July 2008)) and tests using mice that were treated by either ingestion or subcutaneous injections (PATTY (5th, 2001)). However, no data is available on effects of the substance on the reproductive functions and fertility of parental animals due to pre-mating exposure. Therefore, classification is not possible because of insuficient data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Rats that were orally administered with 1800-3200mg/kg of the substance showed symptoms such as lethargy and coma, but these symptoms disappeared within 2 days in surviving animals (SIDS (accessed July 2008)). Based on these results, the substance was classified into Category 3 (narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	In 31-day inhalation exposure tests using rats, 13-week oral exposure tests using rats, 13-week dermal exposure tests using rats, and 13-week dermal exposure tests using rabbits, NOAEL values of the substance were 3.244mg/L (90-day correction: 1.117mg/L), 350mg/kg/day, 880mg/kg/day, and 1000mg/kg/day, respectively (SIDS (accessed in July 2008)). Because all of these NOAEL values exceeded the upper limit of the Category 2 guidance values, the substance was classified into "Not classified" (oral, dermal, inhalation). As relevant information, in these tests documented above, noticeable effects related to the exposure of this substance were rarely observed, with only the exception that increased liver and kidney weights, both without associated histopathology, and slight alterations in some of the clinical test values, were observed at the high dose level (1000mg/kg/day) in 13-week oral exposure tests using rats (SIDS (accessed in July 2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Based on its 96-hour LC50 values of 560-1000mg/L for fish (guppies), 48-hour EC50 of > 1000mg/L for crustaceans (Daphnia magna), and 96-hour EC50 of > 1000mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2005), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since it is water soluble (water solubility = 4.21E+004mg/L (PHYSPROP database, 2008)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information