NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	51594-55-9
Chemical Name	(R)-1-Chloro-2,3-epoxypropane
Substance ID	m-nite-51594-55-9_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	1) Since its flash point reported by ICSC is 33degC (closed cup), the substance was classified into Category 3 (RS isomers). 2) UN 2023, Class 3 (Subsidiary Risk) (RS isomers).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	UN 2023, Division 6.1, packing group II (RS isomers)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition point is reported to be 385degC (Chemical Risk Information Platform (CHRIP)), it does not ignite at room temperature (RS isomers).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains chlorine and oxygen (but not fluorine), which are chemically bonded only to carbon or hydrogen.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data. (The EU's Risk Phrase for this substance is R34: causes burns.)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Although there are no test results available for its R isomers, rat oral LD50 for epichlorohydrin (CAS No. 106-89-8) is 90 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002). Therefore, the substance was classified into Category 3.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Although there are no test results available for its R isomers, rat dermal LD50 for epichlorohydrin (CAS No. 106-89-8) is 754 mg/kg (EHC 33 (1984)). Therefore, the substance was classified into Category 3.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Gases)	Classification not possible	- -	-	-	No data available. As relevant notes, epichlorohydrin (CAS No. 106-89-8) is a liquid by GHS definition.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Although there are no test results available for its R isomers, rat LC50 for epichlorohydrin (CAS No. 106-89-8) by inhalation is 0.95 mg/L (4-hour exposure) or 250 ppm (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002). Therefore, the substance was classified into Category 2.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) was found to be corrosive in skin irritation test using rabbits (Hazard Assessment Report (CERI, NITE) 2004). Therefore, the substance was classified into Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) was found to be corrosive in eye irritation test using rabbits (Hazard Assessment Report (CERI, NITE) 2004). In addition, epichlorohydrin has been found to be skin corrosive. Therefore, the substance was classified into Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) is documented to cause chronic asthmatic bronchitis according to the human health effect data (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002), and it is considered to be a respiratory sensitizer. Consequently, this substance was classified into Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) was found to be a skin sensitizer in guinea pigs (Hazard Assessment Report (CERI, NITE) 2004; ACGIH (2001); Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002; EHC 33 (1984)). Consequently, this substance was classified into Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Since chromosomal aberrations and sister chromatid exchanges were observed in mouse bone marrow (RTECS accessed in November 2007), the substance was classified into Category 2. As additional background information, in vitro reverse mutation tests also gave positive results (RTECS accessed in November 2007).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
6	Carcinogenicity	Classification not possible	- -	-	-	It is rated as "Carc. Cat. 2" by the EU; however, since we cannot verify the data that support the rating, we classified the substance into the "Classification not possible" category. As relevant notes, epichlorohydrin (CAS No. 106-89-8) is rated as "R" by the NTP and "Group 2A by the IARC (equivalent to GHS Category 1B) (US-NTP (2005), IARC 71 (1999)).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Although there are no test results available for this substance, oral administration of epichlorohydrin (CAS No. 106-89-8) to rats showed effects on fertility of male rats such as sterility and decreased numbers of fertilized eggs and implantation (Hazard Assessment Report (CERI, NITE) 2004) while effects on parental animals were not clear. Based on this report, this substance was classified into Category 2.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
8	Specific target organ toxicity - Single exposure	Category 1 (kidney), Category 2 (liver, gastrointestinal system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H371 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	Although there are no test results available for this substance, oral administration of epichlorohydrin (CAS No. 106-89-8) in animal tests resulted in kidney failure, fatty metamorphosis in the liver, necrosis of gastrointestinal tract, and respiratory tract irritation (Hazard Assessment Report (CERI, NITE) 2004). The effect of administration on the kidney was seen at doses that fall under Category 1 guidance values and that on the liver and gastrointestinal tract was noted at doses that fall under Category 2 guidance values. Based on the results above, the substance was classified into Category 1 for the kidney, Category 2 for the liver and digestive system, and Category 3 for respiratory tract irritation.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
9	Specific target organ toxicity - Repeated exposure	Category 1 (gastrointestinal system, respiratory organs, kidney, liver)	Danger	H372	P260 P264 P270 P314 P501	Although there are no test results available for this substance, oral administration of epichlorohydrin (CAS No. 106-89-8) in animal tests resulted in inflammation and degeneration of the digestive system, hyperplasia of mucosa, and degeneration of renal tubules. In inhalation exposure tests, inflammation and degeneration of the respiratory system, pulmonary congestion and edema, hepatic congestion and necrosis, and atrophy of renal tubules were noted (Hazard Assessment Report (CERI, NITE) 2004). Since these effects were seen at doses that fall under Category 1 guidance values, the substance was classified into Category 1 for the digestive system, respiratory system, kidney, and liver.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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