NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	541-73-1
Chemical Name	m-Dichlorobenzene
Substance ID	m-nite-541-73-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Based on a flash point of 63 deg C (closed cup) (GESTIS (Access on August 2015)), it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 500 deg C (HSDB (Access on August 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	The following three reports are available as LD50 values for rats: 580 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)), 1,200 mg/kg (males), 1,000 mg/kg (females) (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), ATSDR (2006)), and 2,300 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), DFGOT vol. 1 (1990)). As two of these correspond to Category 4 and one corresponds to "Not classified" (Category 5 in UN GHS classification), this substance was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of > 2,000 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)) for rats, this substance was classified as "Not classified." The previous classification result was revised.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on a report of an LC50 value (7 hours) of 8,200 mg/m3 (converted 4-hour equivalent value: 1,779 ppm) (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)) for rats, this substance was classified in Category 3. Besides, a reference value in the unit of ppm was applied as vapour without mist, as the LC50 value is less than 90% of the saturated vapor concentration (1,974 ppm (12,081 mg/m3)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on a report of an LC50 value (4 hours) of 17.6 mg/L for rats (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)), this substance was classified as "Not classified." Besides, the reference value for mist was applied as the LC50 value is greater than the saturated vapor concentration (1,974 ppm (12,081 mg/m3)). The category was revised by adding the new information obtained for this investigation.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There are descriptions that this substance is irritating to the skin and causes erythema and pain on contact with the skin (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). From the above, this substance was classified in Category 2. Besides, it is reported that strong irritation occurred after 24-hour occlusive application of this substance in a skin irritation test with rabbits (DFGOT vol. 1(1991)). However, it was not used for this classification as it is the result of 24-hour application.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was reported that in an eye irritation test with rabbits, 24-hour application of 0.1 mL of this substance resulted in slight to severe chemosis and slight corneal opacity (DFGOT vol. 1 (1991), BUA 8 (1987)). In addition, there are descriptions that this substance is irritating to the eye and causes pain on contact with the eye (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). As above, based on reports of severe symptoms, this substance was classified in Category 2A.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, this substance was positive in a micronucleus test with bone marrow cells of mice dosed intraperitoneally (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), DFGOT Vol. 1 (1990), EHC 128 (1991), IARC 73 (1999)) and negative in a chromosome aberration test with the bone marrow cells of Chinese hamsters dosed orally (BUA 133 (1996)). As for in vitro, this substance was negative in bacterial reverse mutation tests (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), ATSDR (2006), DFGOT Vol. 1 (1990), IARC 73 (1999), EHC 128 (1991)). From the above, the positive finding in the in-vivo bone marrow micronucleus test was considered unsuitable for use in evaluation (DFGOT Vol. 1 (1990)), and this substance was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	There is no information available for the classification in terms of carcinogenicity of this substance, in either humans or experimental animals. The IARC classified this substance in Group 3 (IARC vol. 73 (1999)). In terms of other carcinogenicity classifications, the EPA classified this substance as "D (Not classifiable as to human carcinogenicity)" (IRIS Summary (Access on August 2015)) in 1990. From the above, this substance was classified as "Classification not possible" for this hazard class. Besides, because of the revision of the GHS Classification Guidance for the Japanese Government, which was used as a classification criteria, the classification result was changed from the previous one ("Not classified").	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, while there is a description that no effects of either maternal toxicity or fetal developmental toxicity were observed at up to 200 mg/kg/day in a developmental toxicity study with pregnant rats given this substance by gavage during organogenesis (gestation days 6 to 15), this report is considered inadequate as it consists only of a summary without details of the method and results of the study (ATSDR (2006), DFGOT MAK Value Documentation (2013), HSDB (Access on August 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (liver), Category 3 (respiratory tract irritation, narcotic effects)	Danger Warning	H370 H335 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance causes respiratory tract irritation (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), EHC 128 (1991)). It is reported that this substance causes cough, lethargy, and sore throat through inhalational exposure and causes diarrhea, nausea, and vomiting through ingestion (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)), although there are no details specifying whether this pertains to humans or experimental animals. It is also reported that oral administration of this substance to mice at 300 mg/kg (equivalent to Category 1) caused liver damage with significantly increased liver weights and serum ALT activity and extensive centrilobular hepatocyte necrosis (IARC 73 (1999)). It is described that oral administration of this substance to mice at doses of not less than 1,000 mg/kg (equivalent to Category 2) caused ataxia, labored breathing (EHC 128 (1991)), and depression of the central nervous system (narcotic effects) (EHC 128 (1991)). From the above, this substance causes respiratory tract irritation, narcotic effects, and effects on the liver, therefore, was classified in Category 1 (liver) and in Category 3 (respiratory tract irritation, narcotic effects).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	There is no information on humans. In experimental animals, a 10-day oral toxicity test with rats dosed by gavage revealed increased liver weights, hepatic degeneration (vacuolization and swelling) at 368 mg/kg/day (converted guidance value: 40.9 mg/kg/day), which is within the range of Category 2; a 90-day oral toxicity test (gavage) revealed increased liver weights, hepatocellular alterations, and hepatocellular necrosis at 147-588 mg/kg/day, which exceeds the range of Category 2 (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), ATSDR (2006)). Besides, this 90-day test also revealed increased GOT (AST) and cholesterol levels (males), reduced LDH levels (males), decreased thyroid follicular colloid density, and vacuolization of the cells of the adenohypophysis (in males) at 9 mg/kg/day, which is within the range of Category 1, however, these findings were not adopted for this classification as they were considered to be secondary findings associated with hepatic enzyme induction. In addition, a 28-day oral toxicity test with rats dosed by gavage revealed increased liver weights and enzyme induction in the liver (without histopathological alterations) at 100 mg/kg/day (converted guidance value: 31.1 mg/kg/day), which is within the range of Category 2, and hepatocellular hypertrophy and slightly raised serum enzyme activity at 500 mg/kg/day (converted guidance value: 155.6 mg/kg/day), which exceeds Category 2 (BUA 133 (1996), Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). Therefore, this substance was classified in Category 2 (liver).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the kinematic viscosity of this substance is calculated to be 0.810 mm2/sec (25 deg C) from numerical data (viscosity: 1.044 mPa*s (25 deg C), density (specific gravity): 1.2884) listed on the HSDB (Access on August 2015).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 96-hour LC50/EC50 = 2.85 mg/L for crustacea (Mysidopsis bahia) (EHC 128, 1991), it was classified in Category 2.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to being not rapidly degradable (a degradation rate by BOD = 0%, a degradation rate by GC = 0% (Official Bulletin of Ministry of International Trade and Industry, 1983)), and 21-day NOEC (reproduction) < 0.1 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1995), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), it was classified in Category 1.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information