NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	542-75-6
Chemical Name	Propene, 1,3-dichloro-
Substance ID	m-nite-542-75-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since flash point is 25 degC (closed-cup) (ICSC (J), 2004), the substance is classified into Category 3. In addition the substance is classified as Class 3, PG II or III in UNRTDG (UN2047).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since the substance is classified into Class 3 in UNRTDG (UN2047) and it is not classified as Pyrophoric substance, it is classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Since the substance is classified into Class 3 in UNRTDG (UN2047) and self-heating property (4.2) was not assigned, it is classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not oxygen) which is chemically bonded only to carbon.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. As relevant notes, the substance corrodes aluminum and rubber. It is also reported that it corrodes steel in humid, wet condition or at the high temperature state (Hommel (1996)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Eighteen LD50 values for rats (both sex) of 300, 224, 713, 470, 121, 150, 519, 304, 325, 85, 117, 78, 127, 130, 110 - 250, 57, 560 and 510 mg/kg obtained from the individual tests documented in the "List 1" information source designated in the GHS classification guidance for the Japanese government (Registration and application document of pesticide (1997), ACGIH (2005), ATSDR (2008), IARC 41 (1986) and EHC 146 (1993)), were taken into consideration. Eleven of them corresponded to Category 3, and seven of them corresponded to Category 4. The substance was classified as Category 3, since the majority of obtained data corresponded to it.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Two LD50 values for rabbits of 333 and 504 mg/kg (Registration and application document of pesticide (1997) and IARC 41 (1986)) and five LD50 values for rats of 1000, 1300 - 2000, 423, 1575 and 1090 mg/kg (PATTY, 5th (2001) and EHC 146 (1993)) reported in the "List 1" information source designated in the GHS classification guidance for the Japanese government were taken into consideration. For rabbits, Category 3 was adopted, since both of them corresponded to Category 3. And for rats, Category 4 was adopted, since two of them corresponded to Category 3 and three of them corresponded to Category 4. Based on the rabbit data of greater hazard, the substance was classified as Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Nine LC50 (4-hour exposure) values for rats for males and females (855 - 1035, 904, 1000, 727, 595 - 676, 670, 744, 1075 and 1190 ppm) were reported in the data from the "List 1" information source designated in the GHS classification guidance for the Japanese government (Registration and application document of pesticide (1997), IARC 41 (1986) and EHC 146 (1993)). All of them corresponded to Category 3, therefore, the substance was classified as Category 3. As the LC50 values were lower than 90% of the saturated vapor pressure concentration (44737 ppm), it was judged as "vapor hardly coexisting mists" and the criterion values for gas were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There were three reports of rabbit tests. In the first report, 4-hour occlusive application of 0.5 mL of the substance caused slight to moderate erythema and moderate to severe edema, these changes were still present in some of the animals after 14 days (EHC 146 (1993)). In the second study, semi-occlusive application of the substance for 4 hours caused well-defined erythema and moderate edema, and symptoms disappeared completely within 14 days (EHC 146 (1993)). In the third study, 4-hour application of 0.5 mL of the substance caused erythema and slight edema and symptoms disappeared completely within 21 days (EHC 146 (1993)). Based on the information, the substance mainly caused slight to moderate erythema and slight to severe edema, and symptoms disappeared completely within 14 - 21 days. Thus, the substance was classified as Category 2. As relevant information, the substance was classified as "Xi; R36/37/38" in the EU classification.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In the rabbit test, instillation of 0.1 mL of test substance into conjunctival sac caused slight to marked redness, slight to moderate chemosis, reddening of the iris, and discharge. In one animal, irritative reactions of the cornea were found, and those recovered within 14 days (EHC 146 (1993)). In the other rabbit test, moderate to severe conjunctival irritation and minor irritative changes of the cornea, chemosis, and radial responses were observed, and the symptoms disappeared completely within 14 days (EHC 146 (1993)). Based on the information, because the substance caused moderate or more irritation, radial responses, and minor changes of the cornea and the symptoms all disappeared within 14 days, the substance was classified as Category 2A.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In the sensitization tests using guinea pigs, positive rates of two tests (Buehler test) without adjuvants were 25% (5/20) and 90% (9/10), respectively. And in the other two tests (maximization test) with adjuvants, positive rates were 100% (20/20) and 80% (16/20), respectively (EHC 146 (1993)). These positive rates were all beyond the criteria for judging for positive. In human cases, sensitization to the substance was reported in process operator in pesticide manufacturing facility. He developed bullous dermatitis. Patch test with the substance elicited positive responses and it was concluded that the worker was probably sensitized to insecticide formulation containing 95% of the substance (ACGIH (2005)). Based on the information, the substance was classified as Category 1.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	The substance was classified as Category 2 based on the positive results in the micronucleus test using bone marrow cells from mice orally administered (IARC 71 (1999)) and in the chromosome aberration test using bone marrow cells from mice intraperitoneally administered (NTP DB (Access on Jun. 2009)) (in vivo mutagenicity test in somatic cells). As relevant information, as for other in vivo test results were also obtained, i.e., negative results in the dominant lethal test (in vivo inheritable mutagenicity test in germ cells) using rats by inhalation exposure (ACGIH (2005)), negative results in the other micronucleus test using bone marrow from mice orally or intraperitoneally administered (IARC 71 (1999)) and positive results in the DNA damage test using the liver, kidney and others of rats orally or intraperitoneally administered (IARC 71 (1999)). As for in vitro studies, positive results in the Ames test, negative or positive results in the chromosome aberration test (NTP DB (Access on Jun. 2009), Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (1996)) and positive results in the mouse lymphoma assay (NTP DB (Access on Jun. 2009)) were reported. EFSA (and EU) proposed "Muta. Cat. 3; R68" from the positive data of genotoxicity tests, but the proposal was not approved because there was a possibility of the effects of impurities and stabilizers (Evaluation of effect for the food safety (Food Safety Commission) (2009)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	As for the major activity for evaluation of carcinogenicity by authorities, the criteria of "Group 2B" in the IARC (IARC 71 (1999)), "A3" in the ACGIH (ACGIH (2005)), "B2" in the EPA (IRIS (2003)) were reported. Therefore, the substance was classified as Category 2. As relevant information, in the 2-year oral administration tests in rats and mice, an increase in the incidence of papilloma or carcinomas of squamous epithelium of forestomach were found. Furthermore, an increase in the incidence of liver tumors in rats, and increase in the incidences of alveolar/bronchiolar tumors and transitional cell carcinomas of bladder epithelium in mice were reported (NTP TR 269 (1985), IRIS (2003)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Not classified	- -	-	-	In the two-generation inhalation study in rats, as parental toxicity, decreased body weight and histopathological changes in the nasal mucosa were observed. However, no adverse effects were observed in reproduction or neonatal growth or survival (EHC 146 (1993)). In addition, in the developmental study in pregnant rats or rabbits by inhalation during the organogenetic period, decreased body weight gain was observed as the general toxicity of dams in both animal species, however, no adverse effects were observed in reproductive indices such as the number of implantations, resorptions, litter size. There was no evidence of a teratogenic or embryotoxic response (EHC 146 (1993)). Based on these results, there were no adverse effects on sexual functions and fertility of parental animals, or development of offspring. Therefore, the substance was classified as "Not classified"	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, lung)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	As for the information on humans, it was reported that inhalation exposure at lower concentrations resulted in depression of central nervous system (EHC 146 (1993)), and that accidental poisoning by high-dose exposure caused acute neurotoxic symptoms (ACGIH (2005)). In the acute oral toxicity study in rats (LD50 value: 110-250 mg/kg), the signs observed included lethargy, hunched posture, ataxia and tremors (IUCLID (2000)). In the acute dermal toxicity study in rats (LD50 value: 800 - 2000 mg/kg), the signs observed also included lethargy, hunched posture and ataxia, and loss of righting reflex additionally (EHC 146 (1993), IUCLID (2000)). In both routes, the symptoms were noted within the range of doses corresponding to Category 1 of the guidance values, therefore, the substance was classified as Category 1 (nervous system). Further, in these acute toxicity studies in rats, in addition to the neurological symptoms, decreased respiratory rate was observed in each route of three routes for oral, inhalation and dermal. As the autopsy findings in the survivors, congestion of the lungs was found in both oral and dermal routes, while pale and swollen lungs were reported in inhalation route (EHC 146 (1993), IUCLID (2000)). Based on the information, the substance was classified as Category 1 (lung).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (stomach, upper respiratory tract, urinary bladder)	Warning	H373	P260 P314 P501	In the 13-week repeated dose oral study in rats, hyperplasia of basal cells and prominence of mononuclear cells were observed in the proximity of the basement membrane of the forestomach at the dose greater than 15 mg/kg/day (ACGIH (2005)). In the 2-year study, hyperplasia of basal cells or epithelium of the forestomach was also observed as non-neoplastic lesions at 25 or 50 mg/kg/day (NTP TR 269 (1985)). Because the lesions in the forestomach occurred at the dose levels equivalent to Category 2 of the guidance values, the substance was classified as Category 2 (stomach). While as for the information on humans, a farmer in good health developed pain in the ear, nasal mucosa and pharynx by exposure to small quantities of the substance leaked from the hose during his work for soil treatment over 30 days. Hospital examination showed pain in the external ear, hyperemia, superficial ulcerations of the nasal mucosa, and inflammation of the pharynx (EHC 146 (1993)). In the 13-week inhalation (as vapors) studies in rats and mice, it was reported that degeneration of the olfactory epithelium and hyperplasia of the epithelium of respiratory tract was noted at the concentrations of 409 mg/m3 (corresponding to Category 2 of the guidance values) or higher in both species (EHC 146 (1993)). Based on the information, the substance was classified as Category 2 (upper respiratory tract). Additionally, in the 13-week inhalation study in mice, hyperplasia of the transitional epithelium of the urinary bladder was observed at the same dose levels, and the change was also reported in the 2-year inhalation study (IARC 71 (1999)). There was a description stating that the nasal mucosa and urinary bladder were the target organs in inhalation exposure (EHC 146 (1993)). Based on the information, the substance was classified as Category 2 (urinary bladder). Therefore, the result of the classification was Category 2 (stomach, upper respiratory tract, urinary bladder). In addition, it was reported that increases in the incidence of squamous cell papilloma and/or carcinoma in the forestomach and those of carcinoma of transitional cells in the urinary bladder were noted following two-year oral administration (NTP TR 269 (1985)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 48h-LC50 = 0.09 mg/L for crustacea (Daphnia magna) (EHC 146, 1993, etc.).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BOD degradation rate: 3% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1992)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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