NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	544-92-3
Chemical Name	Copper(I) cyanide
Substance ID	m-nite-544-92-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because the observation result of being insoluble in water (SIDS (2011)) was obtained, it is estimated that it does not react vigorously with water.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Inorganic compound containing no oxygen or halogen	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on an LD50 value of 300-2,000 mg/kg (females) for rats (OECD TG 423), it was classified in Category 4.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although there is no concrete description, from a description that a solid of this substance are irritating to the skin (HSDB (Access on September 2014)), it was classified in Category 2. Information in HSDB (Access on September 2014) was added, and the category was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although there is no concrete description, from the description that a dust and solid of this substance are irritating to the eyes (HSDB (Access on September 2014)), it was classified in Category 2. Information in HSDB (Access on September 2014) was added, and the category was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Since the Japan Society for Occupational Health designated copper (corresponding to metal itself or its compounds, not all substances involved in sensitization have been identified) as occupational skin sensitizers Group 2, it was classified in Category 1 although there are no reports of animal test results or epidemiological cases regarding skin sensitization.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (SIDS (2011)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although there is a report that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, no reproductive developmental effects were seen even at doses where parental toxicity was observed (SIDS (2011)), it was classified as "Classification not possible" because it was a screening test, and the data on developmental toxicity including teratogenicity were insufficient, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	There were few data on this substance, and there is only a report that deep coma was seen in accidental cases in workers (ATSDR (2006)). There were no data for experimental animals. Besides, from inhalation exposure to dusts and mists of copper compounds in humans, there is a report of respiratory tract irritation, irritation of the gastrointestinal tract, salivation, nausea, vomiting, gastric pain, hemorrhagic gastritis and diarrhea (ACGIH (7th, 2001)). From the above, it was classified as "Classification not possible" due to lack of data on this substance.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, respiratory organs, blood system), Category 2 (liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Although in humans, there was no report by exposure to this substance alone, there were the following reports of findings on the effects of repeated exposure to cyanides including this substance. In a group of workers exposed to cyanide for a long term from a plating bath containing 3% each of this substance and sodium cyanide, central nervous symptoms and respiratory symptoms such as headache, giddiness, changes in taste and smell, vomiting, effort dyspnea and precordial pain occurred more frequently than in the control group, and increases in hemoglobin, cyanomethemoglobin and lymphocytes were also observed (CICAD 61 (2004)). In another report, in a group of workers exposed to cyanide at plants producing sodium cyanide and potassium cyanide, increased trends in hemoglobin and lymphocytes were observed compared to the control group (CICAD 61 (2004)). From the above, in humans, effects mainly due to cyanide poisoning by the mixed exposure to other cyanide compounds were suggested to be effects on the central nervous system, respiratory organs and blood system. However, when assessing the net hazardous effects in humans on exposure to this substance which is insoluble, the validity should be considered with due consideration of the consistency with experimental animal data. As for experimental animals, in a study in which this substance was administered by gavage to rats for 90 days, effects on the central nervous system (hypoactivity, lethargy, tremors, convulsions), respiratory organs (labored breathing), the blood system (decreased erythrocytes, decreased hemoglobin and decreased hematocrit, pigmentation of the spleen and liver, hyperplasia of hematopoietic tissue of the spleen and bone marrow), and the liver (liver necrosis, increased serum AST and ALT levels) were observed at doses corresponding to Category 2 (4.35-14.5 mg CN-/kg/day: 15.0-49.9 mg/kg/day (a converted value equivalent to this substance)) (CICAD 61 (2004), ATSDR (2006)). In addition, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which this substance was administered by gavage to rats, anemia as an effect on the blood system, and secondary effects associated with it (enlarged spleen, an increase in extramedullary hematopoiesis in the liver and spleen, increased hemopoiesis of the bone marrow) were observed at the dose corresponding to Category 2 (64 mg/kg/day: about 19.9 mg/kg/day (converted guidance value)) (SIDS (2011)). From the above, based on the target organs of human cyanide poisoning and the target organs of experimental animals administered this substance, it was classified in Category 1 (central nervous system, respiratory organs, blood system) and Category 2 (liver).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 72-hour ErC50 = 0.0891 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2011).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and 72-hour NOEC = 0.0181 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2011). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and for 48-hour EC50 = 0.21 mg/L crustacea (Daphnia magna) (SIDS, 2011). From the above results, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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