NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	56-72-4
Chemical Name	O-3-Chloro-4-methylcoumarin-7-yl O,O-diethyl phosphorothioate [chlorpyrifos]
Substance ID	m-nite-56-72-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is flammable (HSDB (Access on June 2015)), but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	It contains P-O (phosphites) in chemical structure, but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	Because it is written that it does not ignite easily (HSDB (Access on June 2015)) although it is flammable, it was judged that it does not ignite in contact with air at normal temperatures without an ignition source.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for solid substances with a melting point of 140 degrees C or lower.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water from water solubility data measured. Water solubility: 1.5 mg/L (HSDB (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the element (O) is chemically bonded to an element (P) other than carbon or hydrogen, but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	Six LD50 values of 41 mg/kg (males), 16 mg/kg (females) (PATTY (6th, 2012), ACGIH (7th, 2006)), 37 mg/kg (females), 139 mg/kg (males) (ACGIH (7th, 2006)), > 240 mg/kg (males), 17 mg/kg (females) (PATTY (6th, 2012), EPA Pesticide (2006), ACGIH (7th, 2006)) were reported for rats. It was classified in Category 2 to which most of the data (4) correspond.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Three LD50 values of 860 mg/kg (ACGIH (7th, 2006)) and > 2,400 mg/kg (males, females) (PATTY (6th, 2012), EPA Pesticide (2006), ACGIH (7th, 2006)) for rats, and 500 mg/kg (ACGIH (7th, 2006)) for rabbits were reported. It was classified in Category 3 to which most of the data (2) correspond.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	From reported of LC50 values (1 hour) of 1.081 mg/L (males) (converted to a 4-hour equivalent: 0.27 mg/L) and 0.341 mg/L (females) (converted to a 4-hour equivalent: 0.085 mg/L) for rats (PATTY (6th, 2012), EPA Pesticide (2006), ACGIH (7th, 2006)), it was classified in Category 2. Besides, a reference value of mist/dust was applied because it is a solid.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	It is reported that it is not irritating in skin irritation using rabbits (EPA Pesticide (2006)). Moreover, it is written that this substance is not irritating to skin (ACGIH (7th, 2006), PATTY (6th, 2012)). From the above results, it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is reported that slight irritation was observed in an eye irritation test using rabbits, and it resolved within seven days (EPA Pesticide (2006)). Moreover, it is written that this substance is slightly irritating to eyes (ACGIH (7th, 2006), PATTY (6th, 2012)). From the above results, it was classified in Category 2B.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is reported that it was not sensitizing in a skin sensitization test using rabbits (EPA Pesticide (2006)), but it was regarded as insufficient data to be used for the classification due to unknown details on test methods and so on.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, a micronucleus test using mouse bone marrow cells after oral administration was negative (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012)). As for in vitro, a bacterial reverse mutation test, a mouse lymphoma test, a chromosomal aberration test, and a sister chromatid exchange test in cultured mammalian cells were all negative. (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012), NTP DB (Access on July 2015))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	As the existing classification in human carcinogenicity, it was classified in A4 by ACGIH (ACGIH (7th, 2006)), NL by EPA (EPA Pesticide (2006)). As test results in experimental animals, in a 2-year carcinogenicity test using rats and mice in an oral route (in the diet), any dose group did not show increased tumor incidence, and there are no significant toxic effects in either rats or mice except weight gain reduction observed in female rats in a high dose group (20 ppm) (NTP TR96 (1979), ACGIH (7th, 2006), PATTY (6th, 2012)). However, because it is written that in the other 2-year diet administration test using rats, decreased plasma and red blood cell cholinesterase activity was observed in females at 5 ppm or higher of a concentration in diet and males at 25 ppm (ACGIH (7th, 2006)), dose selection in the carcinogenicity test by NTP was considered to be appropriate. As above although it corresponds to "Not classified" from the EPA classification result, by prioritizing the ACGIH classification result, the substance was classified as "Classification not possible" in accordance with the GHS classification guidance for the Japanese government which was revised after the previous classification.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	There is no information on reproductive effects in humans. As for experimental animals, in a two-generation reproductive toxicity test using rats in an oral route (in the diet), decreased plasma and red blood cell cholinesterase activity was observed in parent animals, but toxic effects on sexual function and fertility were not found (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012)). Moreover, in a developmental toxicity test in pregnant rats or rabbits in gavage administration during an organogenetic period, maternal animals showed tremors in rats, and death and abortion in rabbits, but developmental effects were not observed in fetuses of either rats or rabbits (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012)). As above, from the existing test results using experimental animals, there is no evidence which causes concern about serious reproductive/developmental toxicity. However, because this substance is a substance targeting the nervous system, and postnatal developmental effects were not sufficiently evaluated like a developmental neurotoxicity, the substance was classified as "Classification not possible" due to lack of data in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Toxicity effects of this substance are typical of organophosphate poisoning. First, plasma and red blood cell acetylcholinesterase inhibition occurred. Toxicity signs by cholinesterase inhibition rapidly occurred, and they were caused by neuromuscular stimulation which is reversible (above EPA Pesticide (2006), ACGIH (7th, 2006), PATTY (6th, 2012)). Moreover, clinical signs in humans in exposure to this substance were caused by muscarinic effects (parasympathetic effects), nicotinic effects (sympathetic and motor effects), and central nervous system effects, and a headache, weakness, dizziness, visual disorder, psychic effects (psychosis), dyspnea, paralysis, convulsions, and coma were observed. It is reported that acute toxicity by this substance resulted from accidents of unintentional or intentional oral ingestion or inhalation exposure to contaminated food according to human case reports (HSDB (Access on June 2015)). As for human cases, total six poisoning cases by ingesting this substance were reported. These were all toxicity signs typical of organophosphate, and there were nausea, vomiting, and abdominal pain one hour after ingestion, toxicity signs by cholinesterase inhibition (sweating, urination, miosis, bronchorrhea, and hypersalivation) after two hours, and a death of one person after three hours, but other patients recovered by treatment. The visual disorder was observed in other cases but resolved by treatment. (above ACGIH (7th, 2006), PATTY (6th, 2012)). As for experimental animals, in oral administration in chicken at 100 mg/kg, marked acute toxicity occurred in all animals which died within 1-8 days, and delayed neurotoxicity was not observed. However, in a dermal application at 50-500 mg/kg (doses corresponding to Category 1) delayed neurotoxicity was found, and incoordination, paralysis, and death were reported (above ACGIH (7th, 2006), PATTY (6th, 2012)). From the above, because this substance has effects on nervous system, it was classified in Category 1 (nervous system).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	There is no human information. As for experimental animals, at 0.25-1.2 mg/kg/day in a 13-week and 2-year repeated oral administration toxicity test using rats, and at 0.775 mg/kg/day in a 1-year repeated oral administration toxicity test using dogs, plasma and red blood cell cholinesterase activity inhibition was observed, but brain cholinesterase activity inhibition was not found. In a 21-day repeated dermal administration toxicity test using rats, the following was observed (EPA Pesticide (2000), ACGIH (7th, 2006)): plasma and red blood cell cholinesterase activity inhibition at less than 2 mg/kg/day (converted to a 90-day equivalent: 0.47 mg/kg/day); brain cholinesterase activity inhibition at 20 mg/kg/day (converted to a 90-day equivalent: 4.7 mg/kg/day); and cholinergic effects (muscle fasciculation, tremors) at 20 mg/kg/day (converted to a 90-day equivalent: 4.7 mg/kg/day). From the above, red blood cell and brain cholinesterase activity inhibition and cholinergic effects were found within a range of Category 1. Therefore, the substance was classified in Category 1 (nervous system).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From LC50 = 0.074 micro g/L for crustacea (Gammarus lacustris) (US EPA: RED, 2000), it was classified in Category 1.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to being not rapid degradable (BIOWIN), MATC (Life-Cycle Study) = 50.5 ng/L for crustacea (Daphnia magna) (US EPA: RED, 2000), it was classified in Category 1.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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