Item | Information |
---|---|
CAS RN | 563-04-2 |
Chemical Name | Tri-3-tolyl phosphate (m-Tricresyl phosphate) |
Substance ID | m-nite-563-04-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | There is a metalloid (P) present in the molecule. However, because there is an observation result that it is insoluble in water (GESTIS (Accessed Sept. 2018)), it is estimated that it does not react vigorously with water. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | [Rationale for the Classification] There are no data in rodents including rats. Therefore, classification was not possible due to lack of data. [Reference Data, etc.] (1) LD50 for rabbits: > 3,000 mg/kg (EHC 110 (1990), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Besides, there is (1), but the details are unknown. [Reference Data, etc.] (1) It was reported that skin irritation in guinea pigs was mild for this substance, moderate for the o-isomer (CAS RN 78-30-8) and p-isomer (CAS RN 78-32-0), and there was no irritation for an isomer mixture (CAS RN 1330-78-5) (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Besides, there is a report in (1), but the details are unknown. [Reference Data, etc.] (1) There is a description that this substance may cause eye irritation if it turns into a vapor under high temperature environment (HSDB (2013)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) There is a report that in a patch test on a person (67-year-old woman) who developed dermatitis, a positive reaction was observed with a 0.5% solution of this substance, but no reaction was observed with a 5% solution of the p-isomer (CAS RN 78-32-0) (HSDB (2013), Carlsen L, et al. (1986)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, the result of a bacterial reverse mutation test was negative (NTP DB (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] As for carcinogenicity, there are no available reports on humans. There are no classification results by domestic and international organizations, and in experimental animals, there is also no test report using this substance of a high purity. Therefore, it was classified as "Classification not possible" due to lack of data. Besides, in carcinogenicity studies in which an isomer mixture was administered by feeding to rats and mice for 2 years in (1), no evidence of carcinogenicity was observed in either sex in either species. [Reference Data, etc.] (1) In carcinogenicity tests in which as a test substance, an isomer mixture of a purity of 79% (tricresyl phosphate (CAS RN 1330-78-5)) containing 21% of this substance, 4% of the p-isomer and less than 1% of the o-isomer was administered by feeding to rats and mice for 2 years, no evidence of carcinogenicity was observed in either sex in either species (NTP TR433 (1994), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), isomer mixtures were classified in Category 1B (GHS Classification Result in FY 2008), but there is no test report using this substance of a high purity. Therefore, classification was not possible due to lack of data. [Reference Data, etc.] (1) There is a report that in a two generation test with mice by continuous breeding using an isomer mixture of a purity of 79% (tricresyl phosphate (CAS RN 1330-78-5)) containing 21% of this substance, 4% of the p-isomer, and less than 1% of the o-isomer as a test substance, in the F0 generation, a decrease in the number of births and an effect on the sperms (decreased sperm count and motility, morphological abnormalities), and also in the F1 generation, a decrease in the pregnancy rate, the number of live births and a decrease in sperm motility were observed (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on the data in (1) and (2), although the o-isomer is a neurotoxic substance, as for the m-isomer, which is this substance, human and experimental animal data from which neurotoxicity were suspected, could not be obtained. Other than these, there are no data with which target organs can be identified other than the nervous system. Therefore, it was classified as "Classification not possible" for this hazard class. [Reference Data] (1) As described in Environmental Risk Assessment for Chemical Substances (Ministry of the Environment) for tricresyl phosphate (CAS RN 1330-78-5), it is stated that the neurotoxicity from ingestion of edible oils and occupational exposure is due to o-isomer (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). (2) There is a description that the intensity of toxicity and neurotoxicity in humans is strong in the order of the p-isomer < m-isomer < o-isomer among the 3 isomers, and oral lethal doses for adults are 1-10 g for the o-isomer, while the m-isomer and p-isomer are practically nontoxic and do not cause demyelination of the nerves (PATTY (6th, 2012)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] There is no information available for classification on the effects of this substance in humans, including effects on the nervous system. There is no test report using this substance of a high purity also in animals. Therefore, classification was not possible due to lack of data. Besides, neither of (1) nor (2) can be said to be effects of administration of this substance and can be used for the classification. [Reference Data, etc.] (1) There is a report that in a study in which tricresyl phosphate (TCP (CAS RN1330-78-5)) consisting of composition ratio of 60-65% of this substance and 30-35% of the p-isomer as a test substance was administered by gavage to rats for 90 days, hematological changes suggestive of anemia were observed in females within the range of Category 2 (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). (2) There are reports that in studies in which TCP of a purity of 78% consisting of 21% of this substance, 4% of the p-isomer and less than 1% of the o-isomer as a test substance was administered by feeding to rats and mice for 13 weeks and 2 years, changes of the adrenal cortex (cytoplasmic vacuolization, etc.) were observed at doses within the range of Category 2 (NTP TR433 (1994)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Reliable acute toxicity data were not obtained. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Reliable chronic toxicity data were not obtained. Although it is not rapidly degradable (not readily degradable, an average degradation rate by BOD: 37% (J-CHECK, 1975)), because reliable acute toxicity data were not obtained, it was classified as "Classification not possible." | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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