Item | Information |
---|---|
CAS RN | 57-06-7 |
Chemical Name | Allyl isothiocyanate |
Substance ID | m-nite-57-06-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 from a flash point of 46 deg C (closed-cup) (ICSC (1997)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule. However, because it is classified in Division 6.1, Subsidiary Risk 3, PG II (stabilized (BHT)) (UN1545) in UNRTDG, it was judged as Type G. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It does not correspond to the hazards of the highest precedence, pyrophoric substances because it is classified in Division 6.1, Subsidiary Risk 3, PG II (stabilized) (UN1545) in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
It was classified in Category 4 based on reports on LD50 values of 339 mg/kg and 490 mg/kg (NTP TR234 (1982), IARC 73 (1999), EPA Pesticide (1993)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
It was classified in Category 2 based on a report on an LD50 value for rabbits of 88 mg/kg (RTECS (2008), E.H. Vernot, et al. (1977)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
It was classified in Category 2 because it is described that in humans, this substance irritates the mucous membranes and induces eczematous or vesicular skin reactions, and the substance strongly irritates the skin and mucous membranes (IARC 73 (1999)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described in HSDB (Access on December 2013) that this substance has a very pungent odor, and its vapour can cause keratitis which interferes with vision. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
This substance was classified in Category 1 because it is listed as a sensitizer in the Frosch contact allergen list (Frosch et al. Contact Dermatitis 5th Ed. (2011)). Besides, the information in IUCLD (2000) was reported in the previous classification, but it could not be identified in this review. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for in vivo, it was negative in dominant lethal tests with mice and rats (IARC 73 (1999)), negative in micronucleus tests with bone marrow cells and peripheral blood of mice and chromosomal aberration tests with bone marrow cells of mice and rats (there is an equivocal result in a chromosomal aberration test with mouse bone marrow cells), and positive in a sister chromatid exchange test with mouse bone marrow cells (NTP DB (Access on September 2013), IARC 73 (1999)). As for in vitro, there are negative and positive results in bacterial reverse mutation tests and chromosomal aberration tests with cultured mammalian cells, and it was positive in a mouse lymphoma test (NTP DB (Access on September 2013), IARC 73 (1999)). Besides, because the sister chromatid exchange test with mouse bone marrow cells that gave a positive result employed intraperitoneal administration using DMSO as a vehicle, its validity is questionable. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Because IARC classified it in Group 3 (IARC 73 (1999)), it was classified as "Classification not possible" according to the revised GHS classification guidance for the Japanese government. Besides, 103-week oral administration tests with rats and mice were conducted, and in rats, males showed transitional-cell papilloma in the urinary bladder, which was not found in the control group, and females showed an increased trend of subcutaneous fibrosarcoma, but an increase in the tumor incidence was not observed in mice. As a result, it is reported that it was carcinogenic in male rats, there was equivocal evidence of carcinogenicity in females, and it was not carcinogenic in mice of either sex (NTP TR234 (1982)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is reported that no effects were observed in fetuses at the dose where maternal toxicity was seen in a developmental toxicity test with rats in the oral route (gavage) (IARC 36 (1985)). And it is reported that in developmental toxicity tests with mice, rats, hamsters, and rabbits in the oral route (gavage), no treatment-related maternal toxicity or teratogenicity was found in any animal species, however, deaths and resorptions of fetuses increased only in mice in the highest dose group (28 mg/kg/day), but it was not significant (deaths or resorptions, the highest dose group: 38/276; the control group: 15/264, the average number of live pups per litter, the highest dose group: 9.92; the control group: 11.3) (IARC 36 (1985)). It was classified as "Classification not possible" because developmental toxicity occurred at the dose that produced maternal toxicity, but it was not significant, and because no test reports on fertility were obtained. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, gavage administration (200-400 mg/kg) to rats caused reversible inactivity, watery eyes, and ruffled fur (NTP TR234 (1982)), and inactivity, ruffled fur, and thickening and necrosis of mucosal surface of the stomach were observed in a gavage administration test with mice (100-800 mg/kg) (NTP TR234 (1982)). The findings in the stomach mucosa were estimated to be caused by irritation of this substance. The other findings were judged to be insufficient to assign the category for the specific target organ, and it was classified as "Classification not possible." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney, urinary bladder) |
Warning |
H373 | P260 P314 P501 |
It is described that effects on the kidney (histological changes indicative of renal dysfunction) were observed at the dose (40 mg/kg/day; (converted guidance value: 18.5 mg/kg/day)) corresponding to Category 2 in a 6-week gavage administration test with rats (IARC 73 (1999)), and epithelial hyperplasia in the urinary bladder (rats) and cytoplasmic vacuolization in the liver (mice) were found within the dose range (12-25 mg/kg/day) for Category 2 in 2-year gavage administration tests with rats and mice (NTP TR234 (1982)). Therefore, it was classified in Category 2 (liver, kidney, urinary bladder). Besides, the previous classification was conducted based on the results of NTP's 14-day and 13-week administration tests alone, but the target organs were specified this time by taking account of the description in IARC and the results of NTP's 2-year administration tests as well. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.077 mg/L for fish (Oryzias latipes) (ECETOC TR91, 2003). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
It was classified in Category 1 due to being not rapidly degradable (BIOWIN), and 28-day NOEC = 0.0085 mg/L for fish (Oryzias latipes) (ECETOC TR91, 2003). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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