NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	59-50-7
Chemical Name	4-Chloro-3-methylphenol
Substance ID	m-nite-59-50-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 590degC (ICSC,1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including oxygen and chlorine, not fluorine, these oxygen and chlorine have not chemically bound to any elements other than carbon and hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Although it is corrosive to metals (HSDB,2003), test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified into Category 4 from minimum value 1,830 mg/kg among LD50 value 5,129 mg/kg , 3,636 mg/kg, and 1,830 mg/kg (DFGOT vol.2 (1991)) of the oral administration test employing a rat. In EU classification, Xn; R21/22 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From LD50 value >5,000 mg/kg (IUCLID (2000)) of the dermal administration test employing a rabbit, it classified into "Not classified". In EU classification, Xn; R21/22 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Since there was no mortality with highest dose 0.704 mg/L in the dust inhalation exposure test employing rats (4 hours) (DFGOT vol.2 (1991)), LC50 value is considered to be >0.704 mg/L, however, classification is not possible since classification cannot be specified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	There is a description, "no skin irritation" (IUCLID (2000)) in the skin irritation/corrosion test with rabbits (OECD TG 404) and in the 24 hour study to administer 2000mg/kg to rats. On the other hand, there are descriptions, "moderately irritating" (IUCLID (2000) in the 4 hour administration study applied to the injured /uninjured shaven skin of rabbits and that of "corrosion" (IUCLID (2000) in the 24 hour study to administer sodium salt of this substance to rabbits. Based on the above-mentioned, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Since there is a description of "remarkable redness and swelling of the conjunctiva and iris, and corneal opacity were seen also on the 7th day " (DFGOT vol.2 (1991)) in the test employing rabbits and also in HSDB (2003), in the test using rabbits, it is described as "Application of 0.05% solution to the eye causes corneal opacity." , and "The corrosion of a cornea, the inflammation of a conjunctiva, an ulcer, iritis, etc. are produced, and they are irreversible for 21 days" , it was classified into Category 1. EU classification is Xi; R41 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	For humans, it has been reported that "positive cases were not observed," however, "0.2-3% of patients showed a sensitizing potential to the substance" in the patch test using a 5% solution in 31 healthy persons and in the patch test using a 20% solution in 66 healthy persons (DFGOT vol.2 (1991)). For laboratory animals, a positive reaction has been described in several tests. For example, "mild redness" was observed in half or more animals in the Maximization tests with 15 guinea pig (DFGOT vol.2 (1991)). As mentioned above, it was classified into Category 1. It can be classified as R43 (EU-Annex I) in the European Union classification and displayed as Sh (ACGIH-TLV/BEI (2005)) in the German MAK list.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the description of "negative" in the body cell in vivo mutagenicity test (micronucleus tests which employed mouse erythrocyte) (HSDB (2003)), it was classified into "Not classified". There is also a description that it was "negative" in UDS test employing the rat hepatocytes in vitro, in the forward mutations (HGPRT) examination employing a CHO cell, and in the reverse mutation test employing a Salmonella typhimurium (HSDB (2003)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Although it is reported that there are no effects on pregnancy rates and fetuses at doses at which "dyspnea and significantly decreased weight gain are observed" (HSDB (2003), IUCLID (2000)) in mother animals in a prenatal developmental toxicity study in rats (OECD TG 414, GLP), there is no data concerning effects on the reproductive functions, so classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	From descriptions of "Temporary irritation to nasal, mucous membrane" (DFGOT vol.2 (1991)) and of "Respiratory tract irritation" (ICSC (1997)) in the rat which was inhaled and exposed to powder dust, it was was classified into Category 3 (Respiratory tract irritation). In addition, for humans, although the case of expressing "left facial numbness" after being exposed to this substance is reported in HSDB (2003), it is only one case, and since it cannot be judged whether it is the consistent effect, it was not adopted. About an animal, although there is description of the effect "the mitochondria of liver, the increase in a small granule vesicle, change of a granular endoplasmic reticulum, enlargement of a bile capillary, etc. are seen" (HSDB (2003)), by the rat by which single time oral administration was carried out, since it is not considered a material impacts, 400 mg/kg is not adopted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (brain, kidney, liver)	Warning	H373	P260 P314 P501	There has been reports of "weight increase of kidney and histopathological changes (kidney papillary necrosis in male rats, kidney cortical enlargement, fibrillization), change of cerebral weight, and histopathological changes" (HSDB (2003)) in the group administered with more than 21.0 mg/kg or more in 24 months mixed feed administration test employing rats and of "pericholangitis of liver and bile duct proliferation " in 160 mg/kg (90 days corresponding value: 26.7 mg/kg) administered group in 21 days dermal administration test employing rabbits (15 times administer), (HSDB (2003)). As mentioned above, it was classified into Category 2 (brain, kidney, liver).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96 hours LC50=0.917mg/L of the fish (Rainbow Trout) (AQUIRE (2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since acute toxicity was Category 1 and there were no rapid degradability (the decomposition by BOD: 0%(standard test method (4 weeks)) Existing Chemical Safety Inspections Data (1983))), it was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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