NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	608-73-1
Chemical Name	BHC or HCH
Substance ID	m-nite-608-73-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Non-combustible (ICSC (J) (1998))	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible (ICSC (J), 1998)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC(J) (1998))	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine and the chlorine is chemically bonded only to carbon (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on the rat oral LD50 = 100mg/kg (PIM257 (2001), HSDB (2003) and RTECS (2004)) and 2428mg/kg (ATSDR (2005)) , we adopted the lowest value to classify the substance as Category 3. [Note] 1,2,3,4,5,6-hexachlorocyclohexane has several stereoisomers (alpha-; beta-; gamma-; delta-isomers, etc.), but this ID for the health hazardswas investigated and classified as CAS: 608-73-1(isomer mixture) . Also refer to the classification results of 1,2,3,4,5,6- hexachlorocyclohexane [Linden] (ID612, CAS: 58-89-9) which is the gamma-isomer.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	It was set as Category 3 from rat dermal LD50 = 900mg/kg (PIM257 (2001), RTECS (2004)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	It was set as category 3 base on rat inhalation LC50 (4hr) = 0.69mg/L (RTECS (2004)). In addition, considering the saturated concentration (about 0.01mg/L) computed from this substance's steam pressure (0.1Pa at 25degC), it was presumed that the experiment was conducted in dust and mists conditions.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	There is the description(ICSC(J)(1998) that dermatitis may be caused by repetition or the long-term skin contact to the human, it is unknown whether SITTIG (4th, 2002)) is caused by an allergic reaction, and data is insufficient and it cannot classify. In addition, also refer to 1, 2, 3, 4, 5, 6-hexachlorocyclohexane [Linden] (ID 612, and CAS:58-89-9).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	There is the negative result of the dominant fatality test using a mouse, and the negative result of the in vivo chromosome aberration test using mouse bone marrow cells (IARC, Suppl.7 (1987), ATSDR (2005), PIM257 (2001)), and it is classified as the out of the Category. In addition, although there is also positive knowledge in mice dominant fatality tests, it is considered as suspicious (IARC, Suppl.7 (1987)). Moreover, Ames test negative (DFGOT vol.5 (1993)) and an in vitro chromosome aberration test positivity (ATSDR (2005), HSDB (2003)) are reported by the in vitro mutagenicity test. In addition, Linden (gamma-body) which is one of the isomer of the quality of this substance is considered as the outside of Category (refer to Linden (ID 612, CAS: 58-89-9)).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Since it is classified into 2B (IARC Suppl.7 (1987)), B-2 (as industrial hexachlorocyclohexane) according to EPA (IRIS (2003)), and R (as Linden and other hexachlorocyclohexane isomeric form) according to NTP (NTP RoC (11th, 2005)), it was set as category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Although no effect was observed in three-generation reproduction studies and teratogenicity tests using rats (ATSDR (2005)), increased embryo absorption and decreased survival fetus were observed (but not teratogenicity) in reproduction and development toxicity tests using mice (ATSDR (2005), HSDB (2003)) and, in ICSC (J) (1998), there was a descriprion that animal tests showed the potential of toxic effects on human reproduction. Thus, it was set as Category 2. In addition, Linden (gamma-body), one of the isomeric forms of this substance, is set as "out of Category" (see Linden (ID 612, CAS: 58-89-9)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	It was considered as Category 1 (nervous system) and Category 3 (respiratory irritant) based on the description that it affects human central nervous system in the document of Priority 1 and 2 (nausea, vomiting, muscle spasm, tremor etc.) (PIM257 (2001), DFGOT vol.5 (1993), ICSC (J) (1998), HSDB (2003)), and it stimulates a nose, a throat, and a respiratory tract (HSDB (2003), SITTIG (4th, 2002)). Also refer to Linden (gamma body) (ID 612, CAS:58-89-9) which is one of the isomer of this product.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system), Category 2 (liver, kidney)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Since symptoms of nausea and tremor in addition to the face and limb paresthesias, headache, and giddiness were observed in the humans who inhaled this product (PIM257 (2001) the document of Priority 1), symptoms such as vomiting, tremor, and paralysis of the hind limbs were observed with the dose being equivalent to Category 1of a guidance value in a rat (ATSDR (2005)), and the effect was observed in liver (cell hypertrophy, centrilobular degeneration, etc.) and kidney (a glomerular degeneration, the tubular necrosis etc. ) with the dose being equivalent to Category 2 of a guidance value (ATSDR (2005), DFGOT vol.5 (1993)), it was classified into Category 1 (central nervous systems) and Category 2 (liver, kidney). Also refer to Linden (gamma object) which is one of the isomers of this product (ID 612, CAS:58-89-9) .	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=0.34microg/L of Crustacea (Pink shrimp) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=893 (existing chemical substances safety inspections data)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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