NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	61788-32-7
Chemical Name	Hydrogenated terphenyl
Substance ID	m-nite-61788-32-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified	- -	-	-	Since the flash point by ICSC(1995) is 157degC(closed type), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 374degC (ICSC,1995)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method suitable for liquid substances is not established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	It is an organic compound not containing oxygen, fluorine or chlorine.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Although LD50 value of the oral administration test employing a rat includes 6,600 mg/kg (Patty (5th, 2001)), 17,500 mg/kg, and 10,200 mg/kg (ACGIH (7th, 2001)), it classified into "Not classified" from 6,600 mg/kg which is a low value and is new data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From LD50 value >2,000 mg/kg (IUCLID (2000)) of the dermal administration test (OECD TG 402, GLP) employing a rabbit, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	This substance is a liquid whose saturated vapor pressure level at 25degC is 1.3 mg/L (128 ppm). Since LC50 value of 4-hour inhalation exposure test employing rats is >4.7 mg/L (ACGIH (7th, 2001)), and LC50 value of 4-hour aerosol inhalation exposure test employing rats (OECD TG 403, GLP) is >4.3 mg/L (IUCLID (2000)), and any of them are over saturated vapor pressure level, the mist standard was applied, however, classification cannot be specified, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although there are descriptions, "moderately irritating, PII value=3.01" and "not irritating, PII value = 0.04" (IUCLID (2000)) in the information source of List 2 in the 24 hour Draize test using 2 rabbits, irritation caused with this substance cannot be denied, because there is a description, "There is a moderate irritation in the rabbits' skin" in the information source of List 1. Therefore, it was classified in Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	From the description of "nonirritating" (ACGIH (7th, 2001)) and of "Draize score:0.3/110" in the eye irritation/corrosion test employing rabbits (OECD TG 405, GLP) (IUCLID (2000)) to eyes of rabbits, it was classified into "Not classified ".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	It was classified into "Not classified" since there is a description of "no sensitization" in the two human patch tests including 50 persons and 51 persons (one case in ACGIH (7th, 2001) and two cases in IUCLID (2000)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified into "Not classified" based on the statement that the body cell in vivo mutagenicity test (chromosome aberration test employing rats bone marrow cell (OECD TG 475, GLP)) was "negative" (ACGIH (7th, 2001), IUCLID (2000)). In addition, as for in vitro mutagenicity tests, there are also descriptions that the Ames examination employing the Salmonella typhimurium, the HGPRT examination employing a CHO cultivation cell, and UDS test employing a rat liver cultivation cell are all "negative" (ACGIH (7th, 2001), IUCLID (2000)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no sufficient data, classification is not possible. In addition, there is a description of "not carcinogenicity" (ACGIH (7th, 2001)) and an "uninfluential at dose 50 mg/L" (IUCLID (2000)) in the 37-week dermal administration test employing male and female mice.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Not classified	- -	-	-	There is a report of "no teratogenicity at doses at which no adverse effects are observed in mother animals" (ACGIH (7th, 2001), IUCLID (2000)) in a prenatal developmental toxicity study in rats (OECD TG 414, GLP). It is also reported in a teratogenicity study in rats (Bio dynamics, Inc, method, GLP) that "there are no effects on the offspring at doses at which decreased feed intake was observed in mother animals" (IUCLID (2000)). In addition, it is reported that "there were no dose-dependent effects on mating or fertility of parent animals which were fed with 30, 100, 300, 1000 ppm (corresponding values: 1.8-2.5, 6.1-8.3, 18.5-24.4, 62.0-81.2 mg/kg) of the substance, and no histopathological degenerations in reproductive organs which were related to administration of the substance" (USCh (2004)) in a two-generation reproductive toxicity study in rats (OECD TG 416, GLP). For the reasons stated above, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	About humans, there are descriptions that "irritation on an upper respiratory tract and nausea symptoms are present" when aerosol was inhaled (ACGIH (7th, 2001)), and that "an airway is stimulated" in the acute inhalation exposure test employing rats, (ACGIH (7th, 2001)) ", therefore, it classified into Category 3 (Respiratory tract irritation). In addition, the acute oral toxicity tests employing rats (OECD TG 401, GLP) has a description that "control of spontaneous movement, and dirt on hairs by diarrhea, feces and urine were seen with general findings, but necropsy findings were normal in all animals" by 10,000 mg/kg (USCh (2004)). Moreover, there is a description that "short term exposure effect: eyes, skin, and respiratory tract are stimulated" (ICSC (1995)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	In a 20-day dermal administration test with rabbits (International Research and Development Corp. method, GLP) it was reported that "at mg/kg there was no systemic toxicity" (ACGIH (7th, 2001), IUCLID (2000)), and in a 90-day oral administration study with rats (OECD TG 408, GLP) it was reported that "there were weight increase in the liver, kidney and adrenal gland (females only) and weight loss in female animals but no toxic effects related to administration of this substance in histopathological studies " (USCh (2004), IUCLID (2000)). Also, in a 90-day aerosol inhalation exposure test with rats (OECD TG 413, GLP) there is a report of "weight loss, increased liver weight and chromodacryorrhea" (IUCLID (2000)), and in a 182-day aerosol inhalation exposure test with rats (Industrial Biotest Laboratory, Inc. method) there is a report of "an increase in SGOT, SAP and SGPT, a reduction in BUN and an increase in liver weight" (IUCLID (2000)). Since these effects are within the range of guidance values for Category 2, we classified it as Category 2 (liver).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	The substance is hydrocarbon. Although the kinematic viscosity estimated from the viscosity of 70 mPa/s (20degC) (15107 Chemical Products) and the density of 1.011 g/cm3 (15degC) (IUCLID (2000)) is 69.2 mm2/s (20degC) and the viscosity at 40C is expected to be lower than 69.2 mm2/s, classification is not possible since it is unknown whether or not the figure is less than the reference value of 20.5 mm2/s.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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