NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	624-92-0
Chemical Name	Dimethyl disulfide
Substance ID	m-nite-624-92-0_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified as Category 2 (the acceptance criteria of GHS: flash point being less than 23 degC, and initial boiling point being more than 35 degC) based on 15 degC of flash point and 109.74 degC of initial boiling point.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: >300degC (ICSC, 2004)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not classified because of UNRTDG Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine and chlorine.	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	SPECIES: Rat ENDPOINT: LD50 VALUE: 190 mg/kg REFERENCE SOURCE: PATTY (5th, 2001) vol.7	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was set as the outside of Category based on the report that there is no death at rabbit LD50 >2000mg/kg (IUCLID (2000)) (PATTY(5th, 2001) vol.7).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Since the saturated vapor pressure concentration of this product is 37871ppm, it is thought that all inhalation tests were done with vapor. It was classified as Category 3 based on the converted value for 4 hour exposure from rat LC50 = 805ppm (PATTY(5th, 2001) vol.7) .	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified as Category 2 based on the description that moderate to severe erythema and edema were observed on rabbits (ECETOC TR66 (1995), PATTY(5th, 2001) vol.7).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on the statement that in the rabbit the eye irritations such as conjunctival injections, edema, and eye irritations are seen (PATTY(5th, 2001) vol.7, IUCLID (2000)), and recovered completely in 4 - 7 days (PATTY(5th, 2001) vol.7), it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1B	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1B. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in a Local Lymph Node Assay (LLNA) (OECD TG 429, GLP) with mice (n=4), the Stimulation Index (SI values) were 2.99 (2.5%), 2.40 (5%), 1.90 (10%), 3.30 (25%), and 4.75 (50%). It was reported that, since no dose-response relationship was observed, a second counting was performed, and the SI values were 3.38 (2.5%), 2.40 (5%), 1.85 (10%), 3.58 (25%), and 4.77 (50%), and the EC3 value was approximately 2.5% (ECHA RAC Opinion (2018), CLH Report (2017), REACH registration dossier (Accessed Nov. 2021)). [Reference Data, etc.] (2) It was reported that, in a Local Lymph Node Assay (LLNA) (OECD TG 429, GLP) in mice (n=4) with a formulation containing 93.1% of this substance, the stimulation indices (SI values) were 0.91 (2.5%), 1.07 (5%), 0.79 (10%), 3.46 (25%), and 4.1 (50%), and the EC3 value was 22.42% (ECHA RAC Opinion (2018), REACH registration dossier (Accessed Nov. 2021)). (3) In the EU, it was classified in Skin Sens. 1 (EU CLP Classification Results (Accessed Nov. 2021)). (4) It was reported that, in a Buehler test (OECD TG 406, GLP, local administration: 100%) with guinea pigs (n=20), the positive rate was 0% (0/20 animals) both 24 hours and 48 hours after challenge (ECHA RAC Opinion (2018), REACH registration dossier (Accessed November 2021), Patty (6th, 2012)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the fact (PATTY(5th, 2001) vol.7) that we found no results of human over generation epidemiology, human over genetration mutagenicity test, and the human in vivo productive cell mutagenicity test, and we found the negative result for the in vivo micronucleus test with the mouse. So we classified it as Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It was classified into category 2 based on that growth delay and teratogenicity of a child were observed in the dose (50 ppm) causing toxicity to parental animals (PATTY(5th, 2001) vol.7) .	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, olfactory organ), Category 2 (blood)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	It was classified into Category 1 (respiratory organs, olfactus organ) based on the statement in rat of the exposure dosage of guidance value within the limits of Category 1, dysplasia of respiratory mucosa in a nasal cavity, withering and cell deletion of olfactory sensory epitheliums were observed (PATTY(5th, 2001) vol.7, IUCLID (2000)). At the dosage in the guidance value range of Category 2 (0.2-1.0 mg/L), the reduction of erythrocyte count, the hemoglobin concentration decrease, and the decrease of a hematocrit value (PCV value) were seen in the rat (IUCLID (2000)). Although at a higer dose, the similar changes were observed also with the rabbit, and it was accompanied by increased reticulocyte counts and increased hematopoietic (PATTY(5th, 2001) vol.7). It is presumed that cause of the effect on erythropoiesis and heme synthesis is inhibition to uptake of Fe to reticuloendothelial system in humans (IUCLID (2000)). Since the above, it is thought that it was the anemia by effects to blood and was classified into Category 2 (blood).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 96-hour LC50 = 1.1 mg/L for fish (Oryzias latipes) (Ecotoxicity tests by Environment Agency, 1998), it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 2000)), and 21-day NOEC = 0.089 mg/L for crustacea (Daphnia magna) (Ecotoxicity tests by Environment Agency, 1998). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 2000)), and 96-hour LC50 = 1.1 mg/L for fish (Oryzias latipes) (Ecotoxicity tests by Environment Agency, 1998). It was classified in Category 1 by drawing a comparison between the above results.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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