NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	62476-59-9
Chemical Name	Acifluorfen sodium salt
Substance ID	m-nite-62476-59-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (N-O) present in the molecule, but the classification is not possible due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	There is the information that "this chemical is a combustible solid but does not easily ignite" (HSDB (2010)), but the classification is not possible due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (N-O) present in the molecule, but the classification is not possible due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	It is classified as "Not classified" from the information that "this chemical is a combustible solid but does not easily ignite" (HSDB (2010)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Na), but it is conceivable that it does not react vigorously with water from data on water solubility as 0.405 g/L (USEPA/HPV (2001)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Classification not possible	- -	-	-	An organic compound contains oxygen, and that is chemically bonded to elements other than carbon or hydrogen (N, Na), but the classification is not possible due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	On the basis of an LD50 value of 122 mg/kg bw for rats (USEPA/HPV (2001), corresponding to List 1), it was classified in Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	On the basis of an LD50 value of 1457 mg/kg bw for rabbits (USEPA/HPV (2001)), it was classified in Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	An LC50 value of >1.38 mg/L/4h for rats was reported (USEPA/HPV (2001)), but it was classified as "Classification not possible" because the category cannot be determined. Besides, a reference value of dust was applied because there is the information of "exposure to aerosol" in the reference.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is the information that "it was moderately irritating to skin in a test using rabbits" (Evaluation of effect for the food safety (2010)), and moderate erythema and slight edema were observed at doses of 3540 to 5000 mg/kg in a rabbit acute dermal toxicity test (USEPA/HPV (2001)), therefore, it was classified in Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	On the basis that "it was severely irritating to eyes in a test using rabbits" (Evaluation of effect for the food safety (2010)), it was classified in Category 2A.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	On the basis of a negative result in a chromosomal aberration test using bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) (OECD TG475, GLP) (USEPA/HPV (2001)), it was classified as "Not classified." Besides, a weakly positive in TA100 (+S9) in an Ames test (Evaluation of effect for the food safety (2010)) and a negative in a chromosomal aberration test in the absence of metabolic activation using CHO cells (USEPA/HPV (2001)) were reported as in vitro tests.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	Carcinogenicity in a 2-year combined chronic toxicity test with carcinogenicity test by diet administration in rats was not observed (Evaluation of effect for the food safety (2010)). But an increase in an incidence of liver tumors and forestomach papilloma in males and females in an 18-month diet administration carcinogenicity test in mice and an increase in a frequency of liver tumors in females in a 2-year carcinogenicity test in mice were observed respectively (Evaluation of effect for the food safety (2010)). However, an evaluation by the Food Safety Commission concluded from a contribution of enzyme induction to a generation mechanism of liver tumors formation in mice and the high possibility that irritation by this substance caused forestomach papilloma that a generation mechanism of these tumors is unlikely genetic toxicity (Evaluation of effect for the food safety (2010)). Therefore, it was classified as "Classification not possible" due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	A two-generation reproduction toxicity test by diet administration in rats reported that observed general toxicity effects in parent animals were decreased body weight in the highest dose group (2500 ppm) in each generation, and decreased food consumption at 500 ppm or higher in F0 generation, and reproductive toxicity effects were decreased number of implantations sites at 2500 ppm in F0 generation and decreased pup viability on day 1 to 4 postpartum at 500 ppm or higher in F1 generation (USEPA/HPV (2001)). Furthermore, in a development toxicity test by oral administration on day 6 to 19 of gestation in rats reported that decreased weights and 3 deaths out of 25 animals were observed in female parent animals in the highest dose group (180 mg/kg), increased resorptions at 180 mg/kg, and a fetal visceral abnormality (slight dilatation of the lateral ventricles of the brain) at 90 mg/kg or higher were observed (USEPA/HPV (2001)). From the above results, it was classified in Category 2 because adverse effects on reproduction were observed at the dose where the general toxicity in parent animals occurred.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (systemic), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	Oral administration to rats showed symptoms of lethargy, prostration, and ataxia at doses of 200 and 400 mg/kg which are above an LD50 value (122 mg/kg), and dermal administration to rabbits (an LD50 value: 1457 mg/kg) showed symptoms of lethargy, ataxia, shallow respiration, and prostration at doses of 990 to 1980 mg/kg (USEPA/HPV (2001)). Specifying target organs from the above symptoms is difficult. But the doses in the above oral administration are within a range of Category 1 in guidance values and death occurred. Therefore it was classified in Category 1 (systemic toxicity). Furthermore, an inhalation exposure of 0.52 to 1.38 mg/L (an LC50 value > 1.38 mg/L) (dust) to rats showed nasal discharge, dyspnea, and crusty nose (USEPA/HPV (2001)), therefore, it was classified in Category 3 (respiratory tract irritation).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	On the basis that a rat 90-day diet administration test showed histopathological findings such as increased liver cell hypertrophy, liver tissue damage, mitotic figures, and increased proliferation of oval cells and bile duct, in addition to elevated alkaline phosphatase and transaminase at the highest dose of 5000 ppm (components of this substance 84 to 93 mg/kg/day) (USEPA/HPV (2001)), it was classified in Category 2 (liver). Besides, observed hematological changes such as lower red blood cell counts and a hemoglobin value were not used as bases for classification due to no related histopathological effects. Furthermore, a 21-day dermal administration test in rabbits, which showed severe dermal irritation with eschar formation dose-dependently along with symptoms such as nasal discharge, hair loss, soft stool, tremors, and decreased activity at 92 to 923 mg/kg/day (converted to a 90-day equivalent value: 21.5 to 215 mg/kg/day) (USEPA/HPV (2001)), did not report clear toxic effects within a range in guidance values.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It is classified in Category 1 from EC50 = 378 ppb for an aquatic plant (Lemnoideae) (U.S. EPA: RED, 2004).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data are not obtained. Because appropriate data on rapid degradability was not obtained and it was classified in Category 1 in acute toxicity, it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information