NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	630-20-6
Chemical Name	1,1,1,2-Tetrachloroethane
Substance ID	m-nite-630-20-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified	- -	-	-	It is non-flammable (HSDB (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is non-flammable (HSDB (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is non-flammable (HSDB (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	It is an organic compound which does not contain oxygen or fluorine but contains chlorine, and the chlorine is not chemically bonded to the elements other than carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	From reported LD50 values of 670 mg/ kg (males) and 780 mg/ kg (females) for rats (IARC 41 (1986)), it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From a reported LD50 value of about 20,000 mg/kg for rabbits (IARC 41 (1986)), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	From reported LC50 values (4 hours) of 2,100 ppm (males) and 2,500 ppm (females) for rats (IARC 41 (1986)), it was classified in Category 3. Besides, a reference value in the unit of ppm was applied as vapour without mist because the LC50 values are lower than the saturated vapour pressure concentration (15,789 ppm).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	It is written that this substance is slightly irritating to rabbit skin (HSDB (Access on July 2015)). Moreover, although there is no specific information, it is written that this substance is irritating to skin (HSDB (Access on July 2015)), but the details are unknown. As above, from the report in rabbits, the substance was classified as "Not classified" (Category 3 in UN GHS classification).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is written that this substance is slightly irritating to rabbit eyes, and it is reported that exposure to the vapour of this substance to dog eyes resulted in no effects found in iris and that effects were not observed even after repeated exposure (HSDB (Access on July 2015)). Moreover, although there is no specific information, it is written that this substance is irritating to eyes (HSDB (Access on July 2015)), but the details are unknown. As above, from the report in rabbits, the substance was classified in Category 2B.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, a micronucleus test and a chromosomal aberration test in mouse bone marrow cells after intraperitoneal administration were positive (NTP DB (Access on August)), and a DNA-binding test in the lung, liver, kidney, and stomach after intraperitoneal administration in rats and mice was positive (IARC 106 (2014)). As for in vitro, it was negative from positive and negative results in a bacterial reverse mutation test, a mouse lymphoma test, a chromosomal aberration test, and a sister chromatid exchange test in cultured mammalian cells (IARC 106 (2014), NTP DB (Access on August)). As above, the substance was classified in Category 2 in accordance with the Guidance.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	There is no usable human information on the carcinogenicity of this substance. As for experimental animals, in a 2-year carcinogenicity test using rats or mice in an oral route (gavage), a trend to increase liver tumors (males: sensitivity was reduced due to a lower survival rate, but significant in a trend test), and increased incidence of fibroadenoma in mammary gland (females, a lower dose only) in rats, and increased incidence of liver tumors (hepatocellular adenoma, hepatocellular carcinoma) (males and females) in mice were observed (IARC 106 (2014), NTP TR 237 (1983)). There is information that in rats, sensitivity in statistical analyses (Mantel-Haenszel test, Cochran-Armitage test, Fisher's exact probability test) was reduced due to a lower survival rate, and evidence of carcinogenicity could not be shown. However, it is reported in NTP that increased incidences of liver tumors in mice are clear evidence of carcinogenicity (NTP TR 237 (1983)). On the other hand, IARC considered that there is a significant increased trend also for liver tumors in male rats by a different statistical test (Life table test), and cocluded that from this together with mammary gland tumor in female rats (fibroadenoma, a lower dose only) and liver tumors in male and female mice, there is sufficient evidence of carcinogenicity in experimental animals (IARC vol. 106 (2014)). As to classification results by other organizations, it was classified in Class C (possible human carcinogen) by US EPA (IRIS Summary (1991)), and in Group 2B by IARC (IARC 106 (2014)). From the above, the substance was classified in Category 2 for this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance is irritating to the respiratory tract (HSDB (Access on July 2015)). As for experimental animals, it is written that in oral administration in guinea pigs at 500 mg/kg, morphological changes of liver damage were shown 24 hours to 11 days after administration (IARC 41 (1986)). However, this knowledge was not adopted for the classification due to unknown details. From the above, the substance was classified in Category 3 (respiratory tract irritation).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	There is no human information. As for experimental animals, in a 2-week oral administration toxicity test using rats, fatty liver was observed at 300 mg/kg/day (converted to a 90-day equivalent: 33 mg/kg/day) within a range of Category 2 (IARC 41 (1986)). On top of that, as effects on liver, micro-vacuolization and centrilobular necrosis in the liver were observed at 300 mg/kg/day in a 10-month gavage administration toxicity test using rats, and at 3430 mg/m3 (converted to a Guidance value equivalent: 2.29 mg/L) in a 12-month inhalation toxicity test using rats and 6-month inhalation toxicity test using rabbits (IARC 41 (1986)), all of which were tests on one dose only. Besides, in a carcinogenicity test using mice in 103-week gavage administration, inflammation, fatty degeneration, necrosis, hepatocytomegaly in the liver were found at the lowest dose of 250 mg/kg/day although above a range of Category 2 (NTP TR 237 (1983)). As above, effects on the liver were observed in a short-term test, and in longer-term tests, effects on the liver were found at their lowest dose although above a range of Category 2, and the lowest effect level could not be determined. Therefore, the substance was classified in Category 2 (liver).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, kinematic viscosity is calculated to be 0.97 mm2/sec (20 degrees C) from numerical data (viscosity: 1.50 mPa.s (20 degrees C), density: 1.5406 g/cm3 (20 degrees C)) listed in HSDB (Access on July 2015).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 24-hour LC50 = 32 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003), it was classified in Category 3.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. Due to being not rapidly degradabe (BioWin), and Category 3 for acute toxicity, it was classified in Category 3.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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