NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	64-19-7
Chemical Name	Acetic acid
Substance ID	m-nite-64-19-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Classified into Category 3 (GHS criteria: flash point >=23 degC and <=60 degC) from the data of flash point 39 degC (closed-cup) (Merck (14th, 2006), ICSC (J) (1997)) and flash point 43 degC (open-cup) (The Society of Synthetic Organic Chemistry, Japan, Dictionary of Organic Compounds, Kodansha (1985)). The substance is classified into C:R10 (Flammable) in EU.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Classified into Not classified since auto-ignition point is 427 degC (ICSC (J) (1997)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no bivalent -O-O- structure in the molecule	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on LD50 values of 3310 and 3530 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	Based on a LD50 value of 1060 mg/kg for rabbits (PATTY (5th, 2001)), the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	A LCLo value of 16,000 ppm for rats (PATTY (5th, 2001)) corresponds to Category 4 or "Not classified", classification was not possible. Since the value is lower than 90% of saturated vapour pressure concentration (20394.7 ppmV * 0.90 = 18355 ppmV), the classification criteria for gas was adopted.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In tests with rabbits and guinea pigs (PATTY (5th, 2001), ACGIH (2004)), the degree of irritation depended on the application concentrations and exposure periods. Concentrations from 50 - 80% produced severe burns and eschar formation. The substance is classified into C; R35 in EU classification. Based on these data, the substance was classified into Category 1. In addition, the pH is 2.4 (1.0M) (Merck (14th, 2006)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Glacial acetic acid causes devastating injury immediately after application to the eyes of rabbits (ACGIH (2004)). In another rabbit test, concentrations of 10% and higher produced severe irritation with permanent corneal damage (IUCLID (2000)). Additionally, there is a case report that accidental application to the eyes followed very quickly by irrigation resulted in corneal opacity and iritis. Regeneration of the epithelium took many months, but corneal opacity was permanent (PATTY (5th, 2001)). Based on these data, the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	There are reports that a patient with bronchial asthma reacted to a acetic acid challenge and that the response was similar to a type-I hypersensitivity reaction in an individual exposed either to alcohol or acetic acid (PATTY (5th, 2001)). Additionally, there is a report that a human developed anaphylactic reactions to ethanol and an immediate type allergy to acetic acid (HSDB (2005)). These reported cases are rare. No other data for human cases or animal test results are available, therefore classification was not possible due to lack of sufficient data. However, since association between this substance and asthmatic attack cannot be excluded, care should be taken when handling the substance.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test and a negative CHO cell chromosomal aberration test (PATTY (5th, 2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	An extensive epidemiological test was conducted at a chemical plant producing acetic acid and acetic anhydride (PATTY (5th, 2001)). Analysis of mortality from cancer among 1359 workers indicated that mortality from all cancers decreased with one exception, mortality from prostate cancer increased (6 cases). It was concluded that the mortality from prostate cancer was difficult to interpret (PATTY (5th, 2001)), therefore, classification was not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a rat test by exposure from parturition until 18 days old (PATTY (5th, 2001)) and a mouse developmental toxicity test by oral administration (HSDB (2005)), no effects on lactation or fetal development were reported. However, classification was not possible since in these tests there is no data for effects on sexual function and fertility by exposure before mating.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (blood, respiratory system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Since there are some case reports that disseminated intravascular coagulopathy, severe hemolysis or ischemic renal failure occurred after ingestion of glacial acetic acid or massive amounts of acetic acid (PATTY (5th, 2001), ACGIH (2004)), the substance was classified into Category 1 (blood system). In addition, based on reports that inhalation exposure can irritate the nose, upper respiratory tract and lung (PATTY (5th, 2001)) and that vapour inhalation to humans may cause corrosive effects on airways and lung oedema (ICSC (J) (1997)), and a report that after an accidental exposure at a petrochemical plant a patient developed both airways obstruction and interstitial pneumonitis (ACGIH (2004)), the substance was classified into Category 1 (respiratory system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Treatment with 3% acetic acid administered intragastrically to rats for 6 months resulted in chronic inflammation of the esophageal mucosa (PATTY (5th, 2001)). Following occupational exposures, workers have complained of digestive disorders with pyrosis and constipation (PATTY (5th, 2001)). A cross-sectional test of 117 female workers found significantly higher prevalence of chronic cough, chest tightness, nasal catarrh, and sinusitis in exposed workers as compared to controls (ACGIH (2004)). However, classification was not possible due to lack of sufficient data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 48h-EC50 = 65000 microg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since it is rapidly degradable (BOD degradation rate: 74% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1993)) and low bioaccumulative potential is estimated (log Kow = -0.17 (PHYSPROP Database, 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information