NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	64741-44-2
Chemical Name	Distillates (petroleum), straight-run middle
Substance ID	m-nite-64741-44-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	UNRTDG No. 1202, Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Category 3 based on UNRTDG Class: 3, PG3	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Classified in UNRTDG No. 1202, Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: >177degC(>70degC) (EHC171(1996))	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	UNRTDG class3 No.1202	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified	- -	-	-	UNRTDG No. 1202 Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified	- -	-	-	UNRTDG No. 1202 Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	UNRTDG No.1202, Class: 3	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Not classified because of SPECIES: Rat; ENDPOINT: LD50; > 5000 mg/kg bw; REFERENCE SOURCE: EHC (1996)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Considering rat dermal LD50 >2000, > 5000 mg/kg (EHC (1996)), it was set as Category which is lower toxicity from Category 3. But it could not be decided, it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Inhalation study of gasoline was done that aerosol is mixed with steam, it was thought that aerosol is main. And It was set as Category 4 based on value 4.6mg/L (IUCLID (2000)) that is lower value of rat inhalation LC50.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was highly irritating in rabbit skin irritation tests. But it was classified as Category 2 because description of irreversible lesions is not observed (IUCLID (2000), EHC (1006)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on the statement of slightly irritating (IUCLID (2000)) by the tests for rabbit eye irritation, it was set as Category 2B. This Category is also supported by the case report in human (eye irritation recovers in four days and injection recovers in 24 hours).	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	Since there is no data, it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	It was put outside of the division, based on the fact that the skin sensitization was not identified in the skin sensitization test with guinea pigs(IUCLID (2000), EHC (1996)).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the negative results in the mice dominant lethality tests and in the rat myeloid cell chromosomal aberration tests (IUCLID (2000)), we classified it as Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was set as 2 based on the category A3 by ACGIH. [special notes] EU has classified diesel fuels into category 3 (it will be Category 2 if a technical guide is obeyed), and desulfurization gas oil into a category 2 (it will be 1B if a technical guide is obeyed). Each of these is considered to be the classifications corresponding to gasoline. On the other hand, IARC classifies with a group 3 to Distillate(light) diesel fuel, and this will become the outside of Category if a technological direction is obeyed. As a result, category of light oil is distributed to 1B, 2, and out of category. By this classifications, the Japanese properties of diesel fuel was also taken into consideration, and it was set as 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	Since there was no significant effect to the reproductive function and reproductive potential, and the development of neonatal in the rat administration test to female in premating and conception, during gravid period, and to male(ACGIH (2003)), it was considered as on the outside of Categry. This classification is supported also because it is not observed developmental toxicity in other test of pregnant rat administrated (EHC (1996))..	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (kidney), Category 3 (respiratory tract irritation, narcotic effects)	Danger Warning	H370 H335 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In the case in which gasoline was exposed in large quantities in humans, there are progressive oliguria and acute tubular necrosis (EHC (1996), ATSDR (1995)), it is classified into category 1(kidney). And based on investigation report of lethargica, coma by kerosene oral ingestion in human (ATSDR (1995)), it is classified into Category 3 (anaesthetic). Moreover, it is classified into Category 3 (respiratory irritation) based on the statement which stimulates a respiratory tracts (ICSC (2004)). In addition, lungs injury by aspiration was classified according to vacuum respiratory toxicity information.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney)	Danger	H372	P260 P264 P270 P314 P501	It was classified to as Category 1 (kidney) since that the acute renal tubular necrosis (EHC (1996), ATSDR (1995)), the acute renal damage accompanied by anemia and thrombocytopenia, etc. are reported in repeated exposure to humans (EHC (1996)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	Category 1 because of "possible to cause chemical pneumonia by misswallowing of the liquid." (ATSDR, 1995)	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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