NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	65996-93-2
Chemical Name	Coal tar pitch (high-temp.)/coal tar pitch
Substance ID	m-nite-65996-93-2_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	It is estimated that there are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	The classification is not possible due to no data. Besides, there is information that it is combustible (ICSC (2002)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	It is estimated that there are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an ignition point of > 500 degrees C (HSFS (2009)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The classification is not possible due to no data (melting point 30 to 180 degrees C (ICSC (2002))).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water from water solubility data measured. water solubility: 0.0035 to 0.0041 mg/L (25 degrees C) (NITE Chemical Risk Information Platform (Access on October 2015))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It is estimated that it is an organic compound which contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is estimated that it is It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	The classification is not possible due to no data (melting point 30 to 180 degrees C (ICSC (2002))).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From reported LD50 values of 3,300 mg/kg, > 5,000 mg/kg, 6,200 mg/kg, and > 15,000 mg/kg for rats (EU-RAR (2008)), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There are two reported LD50 values of > 400 mg/kg and > 5,000 mg/kg for rats (EU-RAR (2008)). Because one corresponds to "Classification not possible," and the other corresponds to "Not classified," it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is written in EU-RAR (2008) that skin signs occurred in exposure to volatile coal tar pitch (including combined exposure to light) in animals and humans, but it is not possible to judge whether they were caused by skin irritation (EU-RAR (2008)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it was concluded that there is a risk of serious damage to eyes (Xi, R41) as eye irritant in occupational exposure to coal tar pitch (fumes, volatiles) (EU-RAR (2008)). Moreover, it is reported that in a test in the application of 10 micro L coal tar pitch distillate into rabbit eyes, congestion of lids (vasodilatation), lacrimation, and slight mucosal discharge were observed after 24 hours but resolved (EU-RAR (2008), IARC 35 (1985)), but the details are unknown.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is written in EU-RAR (2008) that skin signs occurred in humans and animals after exposure to coal tar pitch (volatiles) alone or combined exposure to light, but it is not possible to judge whether they were caused by skin irritation, skin sensitization, or photosensitization. However, it is proposed that this substance is regarded as a skin sensitizer in accordance with the EU-CLP regulation because it contains 1.5% benzo(a)pyrene (a skin sensitizer) (EU-RAR (2008)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	There are no in vivo data on this substance, and as for in vitro, a bacterial reverse mutation test, a mouse lymphoma test and a sister chromatid exchange test in cultured mammalian cells were positive, and a gene mutation test in cultured mammalian cells was negative (ECHA RAC (2011), EU-RAR (2008), IARC 35 (1985), IARC 100F (2012)). Because this substance contains 1.5% benzo(a)pyrene (Muta Cat. 1B), it was classified in "Category 1B" as a mixture (containing 0.1% benzo(a)pyrene or more).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	IARC concluded in 2010 that there is sufficient evidence of human carcinogenicity in occupational exposure to this substance during road paving and roofing from the epidemiological study result suggesting that there is an increased cancer risk in pavers and roofers who are possibly exposed to coal tar pitch (partly including combined exposure to bitumen (asphalt)) (IARC 100F (2012)). Especially, an epidemiological study in roofers or pavers in USA and UK revealed an excess risk of lung cancer, which was also confirmed in a follow-up study on cancer incidence in pavers in Finland and Netherlands (IARC 100F (2012)). Moreover, high lung cancer mortality and incidence were reported among workers who were exposed to an asphalt mixture containing coal tar in early times before 1970 in France and before 1965 in Norway and Sweden. However, by quality improvement of asphalt, the 2003 report did not show a significant increase in either mortality or an incidence (IARC 100F (2012)). Furthermore, it is also written that a relative risk of lung cancer was elevated to 1.49 for a low exposure group and 10.7 for an intermediate exposure group compared to 1 for an unexposed group as a result of analysis by semi-quantitative ranking of coal tar exposure levels (the product of score and years) in a study in road paving workers in Finland (IARC 100F (2012)). As for experimental animals, incidences of skin tumors including skin cancers were observed in all of 6 tests in a dermal application of coal tar pitch to mice, and three tests in a dermal application of coal tar pitch extract to mice (IARC 35 (1985), IARC 100F (2012)). As above, IARC classified this substance in Group 1 by claiming that there is sufficient evidence in humans for carcinogenicity of coal tar pitch exposure involved in paving and roofing, and this substance during work can be a causal substance of lung cancer, and there is also sufficient evidence of carcinogenicity in experimental animals for this substance (IARC 100F (2012)). Besides this, as for this substance (including volatiles), EU classified "Pitch, coal tar, high-temp" in "Carc. 1A" (ECHA Termination of Evaluation (2014)), and Japan Society for Occupational Health classified coal tar and coal tar pitch volatiles in "Group 1" (The Recommendation of Acceptable Concentration (2015)). From the above, this substance was classified in Category 1A for this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	There are no data on this substance itself (Coal-tar, Pitch, High Temperature (CTPHT)). There are test data on "high-boiling coal liquid," coal tar derived products, and creosote as data not usable for evaluating reproductive effects of CTPHT, and fetal toxicity was observed at a dose where maternal toxicity occurred in a developmental toxicity test using pregnant rats. EU regarded this as not usable for classification. However, because this substance contains 1.5% benzo(a)pyrene (Repr. 1B) or lower, and as a mixture containing it 0.5% or more, Repr. 1B classification in reproductive toxicity was proposed for this substance. The EU Committee for Risk Assessment agreed to this (ECHA RAC Opinion (2011)). Therefore, by following EU, also in this hazard classification, the substance was classified in "Category 1B" as a mixture (containing 0.3% benzo(a)pyrene or more) from the classification result of benzo(a)pyrene (CAS number: 50-32-8) in this hazard class (Category 1B (2011)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is reported that this substance is irritating to the respiratory tract, and causes a cough, sneezing, swelling of nasal cavity mucous membrane (PATTY (6th, 2012)). Besides, it is written that the substance has neurotoxicity and causes numbness and tingling in the hands and feet (PATTY (6th, 2012)). It was judged that these symptoms would be caused by repeated exposure although it is unclear. From the above, because this substance is irritating to the respiratory tract, it was classified in Category 3 (respiratory tract irritation).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	It is reported that this substance has neurotoxicity and causes numbness and tingling in hands and feet (PATTY (6th, 2012)). From the above, because this substance has neurotoxicity, it was classified in Category 1 (nervous system).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	The classification is not possible because appropriate data for classsification are not obtained. The classification result was changed from the previous classification by reviewing information based on expert judgment.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	The classification is not possible because appropriate data for classsification are not obtained. The classification result was changed from the previous classification by reviewing information based on expert judgment.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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