Item | Information |
---|---|
CAS RN | 674-82-8 |
Chemical Name | 4-Methylideneoxetan-2-one |
Substance ID | m-nite-674-82-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Since the flash point by IUCLID(2000) is 33degC(closed type), it was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified |
- |
- | - | Although the unsaturated bond is included in molecule, it was classified into Not classified, since it was classified into Class 6.1(secondary risk 3) and PG I in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2521(ICSC, 1998). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 275degC (ICSC,1998)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | The test method suitable for liquid substances is not established. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | The organic compound not including peroxy group in molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
From a description of LD50 value of 540 mg/kg and 613 mg/kg (IUCLID (2000)) in the oral administration test employing rats, it was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Although there is a description of LD50 value of the dermal administration test employing a rabbit being 3,096 mg/kg and 6,730 mg/kg (IUCLID (2000)) and the lower value of 3,098 mg/kg corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It is written in IUCLID (2000) that LC50 values of the 4-hour inhalation exposure test employing rats are 0.311-0.686 mg/L (90.4-199 ppm), 0.94 mg/L (274 ppm), 0.82 mg/L (238 ppm) (IUCLID (2000)), etc., and LC50 value of the 1-hour inhalation exposure test employing rats is 551ppm. When the gas standard is applied from saturated vapor pressure level with 9,860 ppm (20degC)of this substance, 4-hour equivalent LC50 value for 1-hour exposure is 275 ppm. Although these data are within the scope of Category 1 or 2, it was classified into Category 2 since there were much data which correspond to Category 2. In addition, in EU classification, Xn; R20 (EU-Annex I). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Since there is a description, "4.9 Draize units" (IUCLID (2000)) and the study of a cited literature (Ind. Hyg. Found. Am. Chem. Toxicol. Ser. Bull. 6 (1967)) showed the rsult corresponding to "moderate irritation", it was classified in Category 2. In addition, there are descriptions, "moderate"RTECS (2006) in the 24 hour Draize test with rabbits and "mild" in the study with rabbits. Moreover, there is a description, "corrosive, severe heat-burns in the eyes and skin" (HSDB (2003)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
Since AOI 24, 48, and 72 hours after treatment were presumed to be 95/110, 95/110, and 85/110 from a description of "Draize scores of a conjunctiva, the iris, and a cornea are 24 hours after: 20/20, 5/10, 70/80, 48 hours after: 20/20, 5/10, 60/80" (IUCLID (2000)) in the test employing rabbits, it was classified into Category 1. In addition, there is a description of "corrosive, severe burns of the eye and the skin" HSDB (2003) as effect on humans. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification is not possible because there is no data of in vivo examination. In addition, there is a description of "positive" in the Ames test employing a Salmonella typhimurium (IUCLID (2000)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Although there is a description as follows, "No tumor was observed during the study period" (IUCLID (2000)) in the dermal administration test with male mice and in another dermal administration test with female mice respectively, classification is not possible, because there is no study data with male and female rats used and evaluation by major international evaluation institutions has not been performed. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Although there is a description as follows in HSDB (2003), "Fetal toxicity was not obseved with anaimal experiments and exposure to humans, classification is not possible due to insufficiency of data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
Although there is a description of "lung dysfunction due to irritation to mucous membranes" (IUCLID (2000)) in the 4-hours inhalation exposure test employing rats and it is equivalent to Category 1, judging from the guidance value but is a information source of List2 and does not meet the criterion 1b3, according to the guidance, it was classified into Category 2 (respiratory systems). In addition, there is a description of "There is a possibility of lung blister, bronchus spasm, and bronchopneumonia" as a human acute symptom. (HSDB (2003)) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Although the kinematic viscosity of the substance estimated from the viscosity of 0.88 mPa/s (the temperature is unknown) and the density of 1.0897 g/cm3 (HSDB (2003)) is 0.95 mm2/s and the viscosity at 40degC is expected to be 20.5 mm2/s, classification is not possible since the substance is not hydrocarbon. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified into Category 2 from 48 hours EC50=2.6mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (1998)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Although acute toxicity was Category 2, since there were rapid degradability (readily degradable, the decomposition by BOD(standard test method (4 weeks)): 99%(Existing Chemical Safety Inspections Data (1989))) and there were no bio-accumulation (log Kow=-0.39(PHYSPROP Database (2008))), it was classified into Not classified. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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