NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	68-11-1
Chemical Name	Mercaptoacetic acid
Substance ID	m-nite-68-11-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified	- -	-	-	From information of a flash point: 126 deg C (open cup) (ICSC (1998)), it was judged that a flash point will be 93 deg C or higher as well in prescribed closed cup methods, and it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 350 deg C (ICSC (1998)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, it is described that it attacks steel, stainless steel, and aluminum (ICSC (1998)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	There are 3 reports of LD50 values of <50 mg/kg (ACGIH (7th, 2001)), 73 mg/kg (SIDS (2010)) and 114-136 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) for rats. It was classified in Category 3 to which the largest number of data corresponded.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on a report of an LD50 value of 848 mg/kg for rabbits (SIDS (2010), ACGIH (7th, 2001)), it was classified in Category 3.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Since the data that were evidence for the previous classification were quoted from information sources in List 3, and the original report could not be confirmed, it was not adopted for classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on reports of LC50 values (4 hours) (OECD TG 403) of 2.172 mg/L (male) and 1.098 mg/L (female) for rats (SIDS (2010)), it was classified in Category 4. Besides, since there is a description that the test was conducted with aerosols, and the LC50 value was higher than the saturated vapor concentration (0.595 mg/L), the reference value for a mist was applied. A new information source (SIDS (2010)) was added, and the category was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Since necrosis was observed within 5 minutes after application of the undiluted liquid of this substance to the skin of rabbits, this substance was judged to be corrosive (SIDS (2010)). In humans, there are reports that by exposure to this substance at a high concentration, it caused a second-degree burn on the skin (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and that ulcers and a permanent scar were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 1. Besides, this substance was classified as "R34" in the EU DSD classification, and as "Skin Corr. 1B H314" in the EU CLP classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a description that as a result of application of this substance to the eyes of rabbits, strong conjunctivitis and corneal opacity were observed, and no reversibility was observed within 14 days (ACGIH (7th, 2001)). In addition, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	There are multiple reports that positive reactions were observed in humans in patch tests with this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, there is a report that it was negative in a skin sensitization test with guinea pigs (SIDS (2010)). Since there are multiple reports that it was positive in humans, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2010)). As for in vitro, it was negative in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2010), NTP DB (Access on October 2014)). From the above, it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs, systemic)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is irritating to the respiratory tract (SIDS (2010)). In humans, there is a report of acute pulmonary edema, lung injury (hemorrhagic fibrous bronchitis), severe lactacidemia, renal failure, adult respiratory distress syndrome and multiple organ failure consisting of liver failure and rhabdomyolysis in an accidental case by an unknown route, and by the oral ingestion or dermal exposure, corrosion of the mucosa of the oral cavity, pharynx and esophagus with dysphagia, stomach pain with nausea and vomiting, gastric hemorrhage, tachycardia, shallow breathing, oliguria, death due to circulatory collapse, and death from suffocation due to glottis edema. In addition, ulceration of the mucosa at the contact site was reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for experimental animals, nasal irritation, respiratory distress, bradypnea, labored breathing, irregular breathing, mobility reduced, apathy, tremors, paralysis, prostration, reduced reflexes, eye closure, restlessness and posture squatted and pulmonary congestion in the dead animals from inhalation exposure in rats, dyspnea, piloerection, lethargy, ptosis, prostration and convulsions by oral administration to rats, and tremors and convulsions by dermal exposure to mice, were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2010), ACGIH (7th, 2001)). These effects on the central nervous system and respiratory organs were observed at doses within the range corresponding to Category 1. From the above, it was classified in Category 1 (central nervous system, respiratory organs, systemic toxicity).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, liver, kidney)	Warning	H373	P260 P314 P501	There are no findings on effects by repeated exposure in humans. In tests with experimental animals, since this substance is corrosive, the test was conducted with the sodium salt of this substance (CAS RN: 367-51-1). As for in vivo, considering that this substance and its sodium salt show almost equivalent toxicity, classification was conducted based on test results using sodium salts. In a test in which the sodium salt of this substance was administered by gavage to rats for 13 weeks, effects on the blood system (a decrease of the total white blood cell number and lymphocytes, a slight increase in red blood cell number and hemoglobin concentrations, an extension of prothrombin times (PT), etc.), effects on the liver (increased weight, increases in serum AST, ALT and LDH, periportal hepatocellular microvacuolation, single cell necrosis), and effects on the kidney (increase of serum urea and creatinine, proximal tubule vacuolation) were observed at the highest dose of 60 mg/kg/day (corresponding to Category 2) (SIDS (2010)). Other than these, extramedullary hematopoiesis in the spleen and in the liver, cortical atrophy in the thymus, and decreased M/E ratio (myeloid/erythroid ratio) were observed (SIDS (2010)). However, these findings were considered to be related to effects on the blood. On the other hand, in tests in which the sodium salt of this substance was applied dermally to rats or mice for 13 weeks, there was no specific target organ other than local irritation effects on the skin of the application site observed in both species within and lower than the dose range for Category 2 (maximum dose: 180 mg/kg/day in rats, 360 mg/kg/day in mice) (SIDS (2010)), therefore, by the dermal route, it was considered to be roughly equivalent to "Not classified." From the above, it was classified in Category 2 (blood system, liver, kidney). Besides, SIDS (2010) which was issued after the previous classification was used, therefore, classification became possible in this classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 35.8 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment (NITE, CERI, NEDO, 2008)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate: 67% (SIDS, 2010)), and 72-hour NOEC = 2.2 mg/L for algae (Pseudokirchneriella subcapitata) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate: 67% (SIDS, 2010)), and a low bioaccumulation estimate (log Kow = 0.09 (PHYSPROP Database, 2009)) despite 96-hour LC50 = 39.8 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). From the above results, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information