NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	68359-37-5
Chemical Name	alpha-cyano-4-fluoro-3-phenoxybenzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate; cyfluthrin
Substance ID	m-nite-68359-37-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	The substance contains unsaturated bonds. Classification is not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing fluorine, chlorine and oxygen, which are chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	14 values of rat LD50 were obtained in oral administration tests (1271, 869, 1189, 590, 795, 926, 499, 505, 254, 396, 16.2, 500-1000, 155, and 160 mg/kg bw) (JECFA No. 891 (1997)) (DFGOT vol. 23 (2003)). Of these 14 values, nine values represent Category 4 (300 < LD50 <= 2000 mg/kg bw), three values represent Category 3, 1 value represents Category 2, and one value represents "Classification not possible" category. Thus, the substance was classified into Category 4, which best represents the overall results.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on its rat LD50 of > 5000 mg/kg (JECFA No. 891 (1997)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Its documented rat LC50 values consists of one value equivalent to Category 4 (1.089 mg/L), one value equivalent to Category 3 (0.575 mg/L), two values equivalent to Category 2 or 3 (0.469-0.592 mg/L; 0.2-0.735 mg/L), and two values equivalent to Category 2 (0.405-0.49 mg/L) (DFGOT vol. 23 (2003)) (JECFA No. 891 (1997)). Prioritizing best represented category and more toxic values, the substance was classified into Category 2. Also, it is rated as R26/28 (equivalent to Category 1 or 2) or R23 (equivalent to Category 2) in the EU classification (EU-Annex 1 (accessed in February 2009).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since two different tests using rats found that the substance is not irritating (DFGOT vol. 23 (2003)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Since both of two tests using rats found that the substance is a primary irritant (DFGOT vol. 23 (2003)), the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	Since two different maximization tests using guinea pigs (DFGOT vol. 23 (2003)) found that the substance is not skin sensitizing, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As additional information, negative results have been documented in dominant lethal tests using mice that underwent oral administration, and chromosomal aberration tests using bone marrow cells of mice that underwent oral administration. However, these results were not used for classification because of the notes pointing out some defects found in these experiments that made these results less reliable (JECFA No. 891 (1997)). Regarding in vitro mutagenicity tests, negative results were documented in Ames tests, mutation tests using CHO cells, chromosomal aberration tests using CHL cells, and chromosomal aberration tests using human lymphocytes (JECFA No. 891 (1997), DFGOT vol. 23 (2003)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	No increase in tumorigenesis was detected in two-year oral administration tests using rats, and 23- and 18-month oral administration tests using mice (DFGOT vol. 23 (2003)). Thus, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In developmental toxicity tests using rabbits that underwent oral administration (OECD TG 414-compliant) (JECFA No. 891 (1997), HSDB (2008)), embryo resorption occurred at the doses (60 and 180 mg/kg bw /day) that are known to suppress body weight gain in maternal animals. Thus, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In rats that underwent inhalation exposure to 0.405 mg/L/4h (OECD TG 403), continued choreoathetoid movement, cyanosis, irregular respiration accompanied with labored breathing, abnormal phonation, or prone or side position with eyes closed were observed (DFGOT vol. 23 (2007)). Based on these observations, the substance was classified into Category 1 (nervous system). In rodents (rats and mice) that underwent oral exposure, it has been documented that the LD50 values were 291 to 1271 mg/kg, and treated animals showed signs of choreoathetosis, restlessness, salivation, lowered motor functions, ataxia, gait disorder, decreased breathing rate, labored breathing and apathy (DFGOT vol. 23 (2007)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	In 4-week forced oral administration tests using rats, symptoms such as apathy, ataxia, ruffled coat and dyspnoea were observed at 80 mg/kg bw /day (90-day conversion value: 27 mg/kg bw /day, which falls under Category 2). In 1-month oral administration (mixed diet) tests, straddled gait, salivation, nervousness and degeneration of sciatic nerve were observed and these symptoms disappeared when administration was terminated (JECFA No. 891 (1997)). In 3-month oral administration tests using mixed diet, degeneration of sciatic nerve was observed in 5 male and 3 female rats out of 20 rats in 1000 mg/kg-administration groups (11 mg/kg/day, which falls under Category 2 dose range); 1 of 8 affected rats recovered after the end of administration (JECA No. 891 (1997)); and temporal dysbasia and body weight loss were detected (DFGOT vol. 23 (2007)) in 500 mg/kg-administration groups (male dose: 38.9 mg/kg bw /day, and female dose: 42.9 mg/kg bw /day, which fall under Category 2 dose range). Among inhalation tests using rats, in 3-week tests, ungroomed coat, abnormal gait, salivation and a decreased body weight gain during the administration period were observed at 250 microg/L (90-day conversion value: 0.06 mg/L) (JMPR "Summary of toxicological evaluations" (2006) and No. 763 (1987)); in 13-week tests, "non-specific behavioral disturbances" at 20 microg/L (= 0.02 mg/L, which falls under Category 1 dose range) and decreased weight of various organs at 3.0 and 20 microg/L (= 0.003 mg/L and 0.02 mg/L, respectively, which fall under Category 1 dose range) were observed (JMPR "Summary of toxicological evaluations" (2006) and No. 763 (1987)); in 4-week tests, body weight loss in male rats, temporal hyporeflexia or bradykinesia, hypothermia, decreased leukocytes and the thymus weight, and increased uric acid concentration were detected at 6.0 mg/m3 (90-day conversion value: 0.002 mg/L, which falls under Category 1 dose range), and piloerection, and abnormal activities and bradykinesia were recorded after exposure to 46.6 mg/m3 (90-day conversion value: 0.016 mg/L, which falls under Category 1 dose range) (DFGOT vol. 23 (2007)). However, under microscopic examinations, administration of the substance did not show any damage (JMPR "Summary of toxicological evaluations" (2006) and No. 763 (1987)), and there are no cases of histopathological observations (DFGOT vol. 23 (2007)). Based on these results, the substance was classified into Category 1 (nervous system) since the effects of the substance were detected at Category 1 guidance doses.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 48-hour EC50 = 0.000025 mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Its classification for acute toxicity is Category 1 and it is not rapidly degradable (BIOWIN), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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