NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	693-13-0
Chemical Name	1,3-Diisopropylcarbodiimide
Substance ID	m-nite-693-13-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point reported 31 degC (closed-cup) (MSDS (Sigma-Aldrich) (Access on Nov. 2010)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Insufficient data were available. As relevant notes, in the mouse test by non occlusive application of the substance, mild irritation was reported (RTECS (2007)), which was the "List 3" information source designated in the GHS classification guidance for the Japanese government.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Delayed corneal damage though to be effects of the vapour of this substance was seen from (1), and irreversible effects are estimated if tested on a liquid. Therefore, it was classified in Category 1. [Evidence Data] (1) It is reported that as for a liquid of this substance spilled to a table and a floor from a 1 L container due to its break, a worker who wiped it off wearing a respirator, laboratory coat, and impervious gloves for 45 minutes to one hour showed hazy vision after about 12-18 hours, and mild pain in the eyes started after four hours and maximized 34 hours after the exposure, and corneal damage was limited to the outer layer, resulting in temporary blindness and initial visual acuity of 20/200 (eyesight 0.1) that subsided over a 2-week period, and the reporter attributed these effects to the vapour of this substance (NTP TR 523 (2007), C&EN, Nov., No. 5, 2 (1990)). [Reference Data, etc.] (2) A worker cleaned the U-shaped gutter of a floor without wearing appropriate protective gears such as protective goggles after an experiment of producing this substance developed cornea ulceration and alkaline burns on the cornea, and it is reported that this is caused by exposure to the vapour probably of this substance floated around sludge (Workplace Safety Site (Ministry of Health, Labour and Welfare, Accessed 2019)). (3) Based on (1), it is reported that effects of exposure to the vapour of this substance resemble mild to moderate effects of mustard gas (NTP TR 523 (2007), C&EN, Jan. 14, 2 (1991)). Moreover, it is pointed out that it is reasonable to assume that all alkylcarbodiimides cause vesication and carcinogenicity by functioning as dealkylating agents based on mechanism of action for mustard gas. It is described that users of this substance are needed to use glove box, fume hood, and full-face mask (C&EN, Jan. 14, 2 (1991)). (4) It is pointed out that dicyclohexylcarbodiimide (CAS: 538-75-0) which has a similar structure as this substance does causes effects on the corneal epithelium and following notable and delayed keratopathy that subsides (Grant & Schuman (1993)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	The substance was classified as Category 1 since the substance was reported as a skin irritant (Contact Dermatitis, Frosch, 4th (2006)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although the micronucleus test using erythrocytes obtained from mice dermally administered for 3 or 4 months (in vivo mutagenicity test in somatic cells) revealed positive results (NTP TR 523 10 (2007)), the reaction was reproducible but its intensity was approximately twice that of the negative control. Also, positive result in the other micronucleus test using peripheral blood obtained from mice by single intraperitoneal administration (in vivo mutagenicity test in somatic cells) was reported (NTP DB (1995)). But the intensity of reaction was less than twice that of the negative control, and no clear dose response was shown. On the other hand, negative results were obtained in the micronucleus tests using bone marrow obtained from male mice and rats by intraperitoneally administered three times (in vivo mutagenicity test in somatic cells) (NTP DB (1995)). Conclusively, the positive results in every test described above were not clear response and no other sufficient data showing positive results classifiable to the Category 2 were reported. Therefore, the classification was concluded as "Classification not possible". As relevant information, as for in vitro studies, negative results (NTP DB (1994)) and equivocal results (NTP DB (2007)) in the Ames test were reported.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	Insufficient data were available. As relevant information, in the 2-year dermal studies in rats and mice, no increases in the incidence of tumors in relation to the administration of this substance were found in both animals (NTP TR 523 (2007)). No data by other administration routes were reported.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, visual organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] By dermal absorption or inhalation of the vapour of this substance, delayed effects on the visual organs are seen from (1). Effects on the nervous system are known for this substance and are thought to cause temporary blindness and so on. Moreover, because corneal damage was limited to the outer layer, it is assumed to affect the cornea directly, therefore, it was classified in Category 1 (central nervous system, visual organs). [Evidence Data] (1) It is reported that as for a liquid of this substance spilled to a table and a floor from a 1 L container due to its break, a worker who wiped it off wearing a respirator, laboratory coat, and impervious gloves for 45 minutes to one hour showed hazy vision after about 12-18 hours, and mild pain in the eyes started after four hours and maximized 34 hours after the exposure, and corneal damage was limited to the outer layer, resulting in temporary blindness and initial visual acuity of 20/200 (eyesight 0.1) that subsided over a 2-week period, and the reporter attributed these effects to the vapour of this substance (NTP TR 523 (2007), C&EN, Nov., No. 5, 2 (1990)). [Reference Data, etc.] (2) Based on (1), it is reported that effects of exposure to the vapour of this substance resemble mild to moderate effects of mustard gas (NTP TR 523 (2007), C&EN, Jan. 14, 2 (1991)). Moreover, it is pointed out that it is reasonable to assume that all alkylcarbodiimides cause vesication and carcinogenicity by functioning as dealkylating agents based on mechanism of action for mustard gas. It is described that users of this substance are needed to use glove box, fume hood, and full-face mask (C&EN, Jan. 14, 2 (1991)). (3) It is pointed out that dicyclohexylcarbodiimide (CAS: 538-75-0) which has a similar structure as this substance does causes effects on the corneal epithelium and following notable and delayed keratopathy that subsides (Grant & Schuman (1993)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (central nervous system)	Warning	H373	P260 P314 P501	In the 3-month dermal application studies in rats and mice, clinical signs such as convulsion, ataxia, abnormal breathing and lethargy were observed in rats at the dose levels of 80 mg/kg/day or higher, and in mice at the dose levels of 140 mg/kg/day or higher (NTP TR 523 (2007)). Likewise, in the 2-year dermal application study in rats, severe neurological signs frequently observed at 40 mg/kg/day included ataxia, excitability, impaired gait, hypomyotonia, abnormal breathing, lethargy, vocalization and convulsion (NTP TR 523 (2007)). As for the principal pathological findings of the brain included neuronal necrosis, hemorrhage, and/or fibrinoid arteriole necrosis (NTP TR 523 (2007)). The occurrence dose of 40 mg/kg/day was equivalent to Category 2 of the guidance values, and therefore, the substance was classified as Category 2 (central nervous system).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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