NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	700-13-0
Chemical Name	2,3,5-Trimethylhydroquinone
Substance ID	m-nite-700-13-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 460 deg C (GESTIS (Access on Sep. 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 3,200 mg/kg for rats (IUCLID (2000)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	There is a report on an LD50 value of > 200 mg/kg for rabbits (IUCLID (2000)), but because the category cannot be determined, the classification is not possible.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	It was classified in Category 4 based on an LC50 value of 1.5 mg/L/4 hours for rats (IUCLID (2000)). Besides, it was regarded as a test on dust because there is a description of exposure to an aerosol, and the LC50 value was above the saturated vapour pressure concentration (0.0017 mg/L).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It was corrosive in a test by a 4-hour occlusive application to rabbits (IUCLID (2000)), and in a test by a 4-hour occlusive application of an 80% aqueous solution of this substance to rabbits, severe erythema and slight edema remained after eight days, necrosis was also recorded, and it was judged as corrosive (IUCLID (2000)). Therefore, it was classified in Category 1. Besides, it was classified in Xi: R37/38 in EU classification.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It was assessed as irritating in a test in which this substance was applied to the rabbit eye without dilution (OECD TG 405), but 2/3 of the animals were removed from the test after eight days due to severe irritation, and the remaining animals still showed slight corneal opacity and slight conjunctival redness after 21 days. And it was also assessed as irritating in another test in which this substance was applied to the rabbit eye without dilution, but severe conjunctival redness, vascularization, and staphyloma were still observed after eight days, and there was no full recovery. Therefore, it was classified in Category 1. Besides, it was classified in Xi: R41 in EU classification (EC-JRC (ESIS) (Access on Sep. 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that a positive rate was 70% (7/10), and it was judged as sensitizing in a skin sensitization test with guinea pigs (skin painting test) (IUCLID (2000)), but it was List 2 data, and the test method was not the one approved by OECD. Therefore, it was classified as "Classification not possible." Besides, it was classified in Xi: R43 in EU classification (EC-JRC (ESIS) (Access on Sep. 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it was reported to be negative in an Ames test (IUCLID (2000)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG422, GLP), no effects were observed in estrous cycle, copulation index, fertility index, gestation length, and delivery status, but four out of 10 animals died during a gestation period in the high dose group (300 mg/kg), there were a decrease in delivery index and a decreased number of corpus lutea, accompanied by tendencies of low numbers of implantations and total offspring. On observation of lactation, other than total litter loss in one maternal animal found in the 300 mg/kg group, a low number of live offspring due to deaths of maternal animals and low viability index on day 4 due to the total litter loss were observed (Safety Test (Ministry of Economy, Trade and Industry) (Access on Sep. 2012)). The adverse reproductive effects above were not used for the rationale for classification because they were findings only at the high dose where high mortality was seen in maternal animals. Furthermore, because data are insufficient on effects on the development of offspring including teratogenicity, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system)	Warning	H373	P260 P314 P501	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG422, GLP), 3/12 males and 7/12 females died in the 300 mg/kg group (converted guidance value: about 150 mg/kg/day), and they showed principal symptoms such as salivation, irregular respiration, a decrease in locomotor activity, tonic convulsion, and clonic convulsion. Pathological examination revealed an increase in hemosiderin deposition in the spleen, hemosiderin deposition of Kupffer cells in the liver, and myocardial degeneration in the dead animals and a maternal animal that had a total litter loss in the 300 mg/kg group, and an increase in hemosiderin deposition in the spleen was also observed in males in the 60 mg/kg group (converted guidance value: about 30 mg/kg/day). On hematological examination, decreases in erythrocyte counts, hemoglobin levels, and hematocrit values and increases in platelet counts and reticulocyte counts were observed. From the above, because an increase in hemosiderin deposition in the spleen and hemosiderin deposition of Kupffer cells in the liver at 300 mg/kg/day suggested the possibility of hemolytic anemia, and such a tendency was also observed in males at 60 mg/kg/day (equivalent to the guidance values for Category 2), it was classified in Category 2 (blood system). Besides, signs such as convulsions were only found in the 300 mg / kg group, which exceeded the guidance value for Category 2, and myocardial degeneration seen in the dead animals in the 300 mg/kg group was not observed in the other animals.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.97 mg/L for crustacea (Daphnia magna) (IUCLID, 2000).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (a degradation rate by BOD: -6, -6, -7% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and it was classified in Category 1 in acute toxicity.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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