Item | Information |
---|---|
CAS RN | 74-83-9 |
Chemical Name | Methyl bromide |
Substance ID | m-nite-74-83-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Category 1 |
Danger |
H220 | P210 P377 P381 P403 |
Classified into Category 1 since lower explosive limit is 10 vol% (ICSC (2000)). The substance is not classified as Flammable/Combustible gas in UNRTDG and a special provision sets forth that the substance is "combustible only under limited conditions" (UN1062 (not exceeding chloropicrin 2%)). Also, the substance is set forth as "Regarded as a special case depending on the regulatory purposes" according to the criteria for flammable/combustible gas in GHS documents. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Classification not possible |
- |
- | - | No data available. The substance is classified into Division 2.3 in UNRTDG (UN1062 (not exceeding chloropicrin 2%)). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Low pressure liquefied gas |
Warning |
H280 | P410+P403 | The substance is classified as "Low pressure liquefied gas" since boiling point is 4 degC (ICSC (1999)) and critical temperature is 194 degC (Merck (13th, 2001)) exceeding 65 degC. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gaseous substances are not available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on a LD50 value of 104,214 mg/kg for rats (SIDS (2002), Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), the substance was classified into Category 3. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
Based on a LC50 value of 781 ppm in a rat inhalation exposure test (gas) (EHC 166 (1995)), the substance was classified into Category 3. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Since there are a number of case reports describing skin irritation (ACGIH (7th, 2001), ATSDR (1992), SIDS (2002)), the substance was classified into Category 2. In a test where the substance (liquid) was applied to the back of rabbits, very slight erythema was observed in 1/6 animals within 24-hour, which disappeared within 48-hour (Test Data for Supporting Registration of Pesticides (1979)). Application of the substance to the back of rats led to the impairments to the epidermal cells and consequently necrosis (HSDB (2002)). In EU classification, the substance is classified into Xi; R38. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
In a rabbit test (exposure of gas), observed positive reactions in iris and cornea disappeared within 5 days (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008), SIDS (2002)). Based on the report, the substance was classified into Category 2B. As relevant information, the substance is classified as Xi; R36/37/38 in EU classification. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
Based on positive results in micronucleus test by inhalation exposure to mice and rats for 2 weeks (SIDS (2002)) and mouse micronucleus test (ACGIH (2001)), the substance was classified into Category 2. As relevant information, there are reports of positive results from in vivo DNA damage test (SIDS (2002)). From in vitro mutagenicity tests, there are reports of positive reverse mutation test and chromosomal aberration test (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Carcinogenicity | Not classified |
- |
- | - | Based on the classifications of "A4" in ACGIH (ACGIH (2001)), "Group 3" in IARC (IARC (1999)) and "D" in EPA (EPA (1990)), the substance was classified as "Not classified". In 2-year inhalation (systemic exposure) tests in rats and mice, increased incidences of tumors were not observed in both sexes of either species, and there were no evidences of carcinogenicity of methyl bromide in F344/DuCrj (Fischer) rats or Crj:BDF1 mice (Results from Carcinogenicity tests (Ministry of Health, Labour and Welfare) (1989)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In developmental toxicity tests in rabbits, increased incidence of anomalies (fused sternebrae, missing gallbladder or missing some lobe of lung) was observed in fetuses at dose levels in which maternal general toxicity was observed (SIDS (2002), IRIS (2002), Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)). Based on the data, the substance was classified into Category 2. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, respiratory organs, liver, kidney, gastrointestinal system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
In human exposure cases, confusion, convulsion, coma, reduced vision, nausea, vomiting, renal failure, gastrointestinal disorder and hepatotoxic symptoms are reported (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)). Based on this information, the substance was classified into Category 1 (nervous system, kidney, alimentary system, liver). In animals, dyspnea, ataxia, changes in the stomach (distention, redness, adhesions, ulceration) (SIDS (access on 6, 2009) and hepatic necrosis were observed following oral exposure in rats and mice (EHC No. 166 (1995)). In addition, decreased locomotor activity, decreased respiratory rate and pneumonia-like changes were observed at dose levels within the guidance value range for Category 1 (2500 ppmV/4h or less) following inhalation exposure in rats and mice (Test Data for Supporting Registration of Pesticides (1980)). Based on the data, the substance was classified into Category 1 (respiratory system). Although there is a report of congestion in the kidney and adrenal gland (Test Data for Supporting Registration of Pesticides (1980)), the details are unknown. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, heart, blood) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Since effects on the cranial nerves are reported in humans (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), the substance was classified into Category 1 (nervous system). In a 13-week inhalation test in rats decreases in hematocrit, hemoglobin and erythrocyte count were observed at 87 ppm, which falls within the guidance value range for Category 2 (50 - 250 ppmV) (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008), NTP TR385 (1992)). In addition, in a 13-week oral dose test in rats, anemia was observed at 36 mg/kg/day, which falls within the guidance value range for Category 1 (less than 50 mg/kg/day) (IRIS (2002)). Based on the data, the substance was classified into Category 1 (blood). In a 3-week inhalation exposure test in rats (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), degeneration of myocardium, degeneration and necrosis in the testis, lethargy, tremor and paralysis of limbs were observed at 26.7 ppm and higher levels, which falls within the guidance value range for Category 1 (less than 50 ppm). Additionally, necrosis and fibrillization of myocardium are reported at 33.3 ppm and higher levels in another 3-week inhalation exposure test in rats (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)). Based on the data, the substance was classified into Category 1 (heart). In 13 - 25 week oral dose tests (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), chronic inflammation and fibrillization in the stomach were observed at 36 - 50 mg/kg/day, which fall within the guidance value range for Category 1 (less than 50 ppm), and lymphocytic infiltration in the glandular stomach and chronic inflammation in the esophagus were observed at 50 mg/kg/day. These data were not used for classification, since the effects were attributed to irritation of the substance. Findings of degeneration and necrosis in the testis noted in a 3-week inhalation exposure test in rats correspond to Category 2 of reproductive toxicity, and were not used for this classification. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
Classified into Category 1 from its 96h-LC50 = 0.7 mg/L for fish (Oryzias latipes) (Hazard Assessment Report (CERI, NITE), 2008). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BOD degradation rate: 15, 17% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1991)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | Category 1 |
Warning |
H420 | P502 | This substance is listed in Annexes to the Montreal Protocol. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
|