NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	74-87-3
Chemical Name	Chloromethane, (alias Methyl chloride)
Substance ID	m-nite-74-87-3_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	Classified into Category 1 since lower explosive limit is 8.1 vol% in ICSC (2000). The substance containing stabilizers is classified into Division 2.1 in UNRTDG (UN1063).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified	- -	-	-	The substance is classified into Division 2.1 in UNRTDG (UN1063). Combustible gas.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Low pressure liquefied gas	Warning	H280	P410+P403	Classified as "Low pressure liquefied gas" since boiling point is -24.2 degC (ICSC (1999)) and critical temperature is 143.10 degC (HSDB (2009)). The substance is classified into Division 2.1 in UNRTDG (UN1063).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gaseous substances are not available. Information is available that is the substance corrodes aluminum, zinc, magnesium and their alloys (Hommel (1996)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a LD50 value of 1800 mg/kg for rats (SIDS (2003), Initial Environmental Risk Assessment of Chemicals (Ministry of Environment) vol.3 (2004)), the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on LD50 values of 2566 ppm and 2700 ppm for rats (SIDS (2003)), the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available. As relevant information, there is a report that frostbite may result from contact with the liquid substance (HSDB (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Although there is a report that exposure of a rabbit eye to the gas for 90 seconds caused only slight conjunctival hyperemia (SIDS (2003)), classification was not possible due to lack of data from standard irritation tests. As relevant information, frostbite may result from contact with the liquid substance (HSDB (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. A positive result in a dominant lethal test (IRIS Toxicological Review (2001), CICAD 28 (2000), (IARC 71 (1999)) was not used for classification, since it is reported in a document in List 1 that the result is due to an inflammation effect. From in vitro mutagenicity tests, there are reports of a positive human lymphocyte gene mutation test, a positive sister chromatid exchange test, a positive Syrian hamster fetal cell (infected with adenovirus SA7) transformation test (Hazard Assessment Report (CERI, NITE) (2006), Initial Risk Assessment Report (NITE, CERI, NEDO) No. 40 (2005)) and a positive bacterial forward mutation test and a positive reverse mutation test (Hazard Assessment Report (CERI, NITE) (2006), Initial Risk Assessment Report (NITE, CERI, NEDO) No. 40 (2005), NTP DB (access on June 2009), CICAD 28 (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classifications of "Group 3" in IARC (IARC (1999)), "A4" in ACGIH (ACGIH (2001)) and "D" in EPA (EPA (2008)), the substance was classified as "Not classified". Two-year inhalation tests were conducted in rats and mice (two tests in both species). In one test in rats, increased incidence of follicular adenoma and follicular adenocarcinoma in the thyroid (combined) was observed only in the males. In mice, a significantly increased incidence of kidney tumor in the males of the high dose group was observed in one test, and an increased incidence of bronchiolo-alveolar adenoma in the females was observed in the other test (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 40, Results from Carcinogenicity tests (Ministry of Health, Labour and Welfare) (1997)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In a two-generation reproductive test in rats, no viable litters were produced and tubular atrophy in the testes and granuloma in the epididymis were observed in parental animals at dose levels in which general toxicity (reduced body weight gain) was manifested in parental animals (Hazard Assessment Report (CERI, NITE) (2006)). In two developmental toxicity tests in mice, the heart defects (absent or reduced atrioventricular valves, tricuspid valves and papillary muscles and/or chordae tendineae under the bicuspid valve, small right ventricle, globular heart, and white spots in the left ventricular wall) were observed at doses that were not parental toxic (Hazard Assessment Report (CERI, NITE) (2006)). Based on the data, the substance was classified into Category 1B.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, cardiovascular system, liver, kidney), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In humans, there are reports of (a) "dizziness, frailty, blurred vision, ataxia, lethargy, insomnia, confusion, paresthesia, neurosis and depressive symptom following inhalation exposure", (b) "nausea, severe headache, drunkenness, confusion, somnolence, ataxia and dysphasia following ingestion" and (c) "abnormal ECG, tachycardia and increased heart rate, decreased blood pressure and increase of relative risk of death by cardiovascular diseases" (Hazard Assessment Report (CERI, NITE) (2006)). Based on the data, the substance was classified into Category 1 (nervous system, cardiovascular system). 6-hour inhalation tests were conducted with mice and rats. Hematuria, degeneration and necrosis of the proximal convoluted tubules and hepatic necrosis was reported for mice at a dose level of 1000 ppm (4-hour equivalence: 1225 ppm) (ACGIH (2001)), and hepato toxicity and renal toxicity was reported in mice at dose level of 2000 ppm (4-hour equivalence: 2690 ppm) or higher concentrations (CICAD 28 (2000)). Similar findings were also reported in rats at a dose level of 3500 ppm (4-hour equivalence: 4287 ppm) or higher (ACGIH (2001)). Since the effects in mice were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (liver, kidney). Since lethargy and somnolence are reported following exposure (Hazard Assessment Report (CERI, NITE) (2006)), the substance was classified into Category 3 (narcotic effects). In conclusion, the substance was classified into Category 1 (nervous system, cardiovascular system, liver, kidney) and Category 3 (narcotic effects).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, central nervous system)	Danger	H372	P260 P264 P270 P314 P501	For human exposure to the substance, there are reports of "effects on the liver and kidney, including jaundice, anuria and proteinuria" (Hazard Assessment Report (CERI, NITE) (2006)); "liver cirrhosis, renal damage, nervous system dysfunction" (IARC vol. 71 (1999)); "effects on the central nervous system such as difficulty in accommodation and diplopia" (ACGIH (2001)); and "dizziness, lalopathy, shivering, ataxia, mental confusion, sleep disorder and visual disturbance" (BUA No. 114 (1993)). In addition, there are case reports describing effects on the liver and kidney (ACGIH (2001)). Based on the data, the substance was classified into Category 1 (liver, kidney, nervous system). In inhalation (6h/day) tests in mice, hepatocellular vacuolization at 750 ppm and higher concentrations following 90-day exposure (Hazard Assessment Report (CERI, NITE) (2006)); degeneration of the cerebellum at 1500 ppm (90-day equivalent: 233 ppm) following 2-week exposure (Hazard Assessment Report (CERI, NITE) (2006)); and axonal swelling and degeneration at 50 ppm following 2-year exposure (SIDS (2003)) were observed.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 48-hour EC50 = 200 mg/L for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2005), SIAR, 2003) and 96-hour LC50 = 270 mg/L for fish (Menidia beryllina) (CICAD, 2000, Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2004), Initial Risk Assessment (NITE, CERI, NEDO, 2005), SIAR, 2003).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1988)) and it is classified as "Not classified" in acute toxicity.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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