NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	74-89-5
Chemical Name	Methylamine
Substance ID	m-nite-74-89-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	Flammable range with air is 4.9-20.7 vol%.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified	- -	-	-	Flammable gas	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Low pressure liquefied gas	Warning	H280	P410+P403	Critical temp: 156.9degC	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	There is a description of LD50 value 100-200 mg/kg (ACGIH (7th, 2001), DFGOT vol.7 (1996)), and 698 mg/kg (DFGOT vol.7 (1996), IUCLID (2000)) of the oral administration test where 40% solution was administered to a rat. Moreover, there is description of 100-200 mg/kg (DFGOT vol.7 (1996), Patty (5th, 2001) and IUCLID (2000), HSDB (2008)) as LD50 value of the test where 10% solution was administered orally to a rat. Since two or more LD50 values fall within the range of Category 3, it was classified into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Since LC50 values of the 4-hour inhalation exposure test employing rats were 4,400 mL/m3 (4,400 ppm), and 6,400-9,100 mL/m3 (6,400-9,100 ppm) (DFGOT vol.7 (1996)), it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Since it was gas on a GHS definition, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Since it was gas on a GHS definition, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Although there is no data of skin irritation test with this substance (gas), the solution seems to have a skin corrosion from descriptions that 40% solution causes a necrosis on skin of rabbits (Patty (5th, 2001)) and that "40% solution causes a necrosis on skin of guinea pig 40%" (ACGIH (7th, 2001)). It was classified as Category 1with unknown further data and without subdivision. In addition, a solution with 10% or more of this substance concentration can be classified as R34 in the EU classification (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Although there is no data of eye irritation test with this substance (gas), it has been described that "serious irritation was developed in eyes of rabbits" with 40% solution (ACGIH (7th, 2001)), or that "corneas were damaged 5 minutes after exposure" (Patty (5th, 2001)). This substance was classified into Category 1since it was a skin corrosive substance, and there have been descriptions of "irritative, European Union classification: risk of serious damage to eyes" in the eye irritation test with 40% solution employing rabbits (IUCLID (2000)) and of "corrosive to eyes" in the section of short term exposure, ICSC (2003) although there was no description about recovery properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	It has been described that "one worker had an allergic or irritative bronchitis" (ACGIH (7th, 2001), NTP DB (Access on January 2009), and Patty (5th, 2001)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Classification is not possible since this case is the only case report with non-public and unspecified data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is a description of "positive" (NTP DB (Access on January 2009), IUCLID (2000)) in a productive cell in vivo heritable mutagenicity test (dominant lethal test by inhalation exposure employing a rat), there is a statement that "the test details are unknown and it cannot be evaluated."(IUCLID (2000)). Classification is not possible because there is no other data of in vivo examination. In addition, there are descriptions of "positive" in the mouse lymphoma assays and "negative" (NTP DB (Access on January 2009)) in the reverse mutation test employing salmonella as an in vitro mutagenicity test.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	There is a description as follows in the inhalation exposure test using pregnant rats, "Although fetal death after implantation increased depending on the dose level, evaluation cannot be made, because study details are unknown" (DFGOT vol.7 (1996). Moreover, there is a description as follows in the reproductive toxicity study via oral administration using female rats, "Although no effect related with administration was observed on estrous cycles, reproductive capabilities, pregnancy, live baby birth, breast feeding, average body weight of baby animals at birth and at weaning, significant decrease in the number of fetuses per litter was observed"(NTP DB (Access on January 2009), IUCLID (2000)). It has been concluded as follows regarding this in IUCLID (2000), "No evaluation can be made because details of results are unknown." On the other hand, there are descriptions as follows in the reproductive toxicity study via administration into the ventral cavity using female mice, " No toxicity was observed in mother animals and child animals" (NTP DB (Access on January 2009), IUCLID (2000)) and "No reproductive toxicity was observed" (IUCLID (2000)). Classification is not possible, because sufficient data are not available as mentioned above.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In Japan Assoc. of Industrial Health (1979) recommendations, there are descriptions of "Cough and breathing difficulty occur," "Oppressive irritation at 100 to 500 ppm occurs, and temporary irritation of the eye, nose, and throat at 20-100 occur in a short time." and "The inflammation of tracheal gill, bronchus, and lungs and the lung blister occur if the high concentration at lethal dose or near the lethal dose was inhaled." in animals. Moreover, there are descriptions of "Dronchial pneumonia occurred and was critical depending on dosage" in the inhalation exposure test employing rats (DFGOT Vol.7 (1996)) and of "Corrosiveness is shown to the airway. When high concentration is inhaled, lung edemas may occur."(ICSC (2002)). Furthermore, there is description of "Aliphatic amines may irritate an airway and cause difficulty breathing, upper respiratory tract disorder, bronchitis, pneumonia and lung oedema. Moreover, headache, nausea, weakness and anxiety neurosis may be temporarily caused after inhalation" (HSDB (2008)), and there is description of "This guideline is based on the information on low molecular weight amines including Methyl amine." in BASF Chemical Emergency Medical Guidelines Aliphatic amines (Reviewed 2006) which is the attribution of this information. As mentioned above, it was classified into Category 1 (respiratory system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory system, liver)	Warning	H373	P260 P314 P501	In the 4-month nasal i inhalation exposure test in male and female rats, "there are reports of functional disorders in nervous system, liver and blood enzyme, and changes in immunologic indicators and the shape of organs, but there is no report about detailed method or data " (DFGOT vol.7 (1996), IUCLID (2000)). Moreover, HSFS (2004) shows that "the substance may cause lung irritation and bronchitis. High-concentration exposure may have effects on liver function." Therefore, it is classified into Category 2 (respiratory systems, liver).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is gas according to the GHS definition, it is classified as "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	it carried out the outside of Category from 48-hour EC50=163000microg/L of Crustacea (Daphnia magna), and others(AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since not water-insoluble (water solubility=1.08*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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