Latest GHS Classification Results by the Japanese Government (edited by NITE)

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GENERAL INFORMATION
 
Item Information
CAS RN 74115-24-5
Chemical Name 3,6-Bis(2-chlorophenyl)-1,2,4,5-tetrazine
Substance ID m-nite-74115-24-5_v2
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) To Guidance List
UN GHS document (External link) To UN GHS document
FAQ(GHS classification results by the Japanese Government) To FAQ
List of Information Sources (Excel file) List of Information Sources
List of Definitions/Abbreviations Definitions/Abbreviations
Sample Label by MHLW (External link) MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) To OECD/eChemPortal (External link)

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Explosives Classification not possible
-
-
- - There is a chemical group associated with explosive properties (neighboring nitrogen atoms) in the molecule, but the classification is not possible due to no data. Besides, it is used as a pesticide (miticide), not as explosives. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7 Flammable solids Classification not possible
-
-
- - No data available. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with explosive properties (neighboring nitrogen atoms) in the molecule, but the classification is not possible due to no data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10 Pyrophoric solids Classification not possible
-
-
- - No data available. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14 Oxidizing solids Not classified (Not applicable)
-
-
- - The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17 Desensitized explosives -
-
-
- - - - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on an LD50 value of > 3,200 mg/kg for rats (RTECS (2013), the original article: British Crop., Protection Council (1981)). Besides, the classification was conducted based on data in RTECS (2013) obtained in this investigation. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Inhalation: Gases) Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Inhalation: Vapours) Not classified (Not applicable)
-
-
- - Solid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2 Skin corrosion/irritation Not classified
-
-
- - In a skin irritation/corrosion test with six guinea pigs, as a result of the 24-hour application of 66.6 mg/0.2 mL of this substance to the skin, very slight edema was observed on 2/12 sites. No systemic toxicity was seen at necropsy after the 7-day observation period, and no histopathological changes were found in the samples of the skin where this substance was applied (JMPR (2005)). It is concluded in JMPR (2005) that this substance caused negligible irritation to the skin of guinea pigs. It was classified as "Not classified" in the Classification JIS (Category 3 in UN GHS classification) based on the above information. The information in JMPR (2005) obtained in this investigation was added. "Not classified" in the Classification JIS (Category 3 in UN GHS classification) was specified based on the GHS classification guidance for the Japanese government. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
In an eye irritation/corrosion test with six rabbits (according to OECD TG 405), mild conjunctival hyperemia was observed in 6/6 animals, but this returned to normal within two days after application. No discharge, chemosis, corneal damage, or iridial inflammation was seen (JMPR (2005)). It was classified in Category 2B based on the above information. The information in JMPR (2005) obtained in this investigation was added. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4 Skin sensitization Not classified
-
-
- - In JMPR (2005) obtained in this investigation, it is reported that in a maximization test with 20 guinea pigs, mild redness was observed in 1/20 animals 24 hours after the removal of the challenge patch, but this disappeared 48 hours after the removal of the patch, and it is concluded in JMPR (2005) that it was not sensitizing to the skin of guinea pigs. Therefore, it was classified as "Not classified." The information in JMPR (2005) obtained in this investigation was added. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a dominant lethal test with rats and a micronucleus test with mouse bone marrow cells (JMPR (2005), IRIS (2012)). As for in vitro, it was negative in a bacterial reverse mutation test, and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (JMPR (2005), IRIS (1991)). FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6 Carcinogenicity Category 2


Warning
H351 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 2 because the EPA classified it in C (IRIS (1991)). The category was changed according to the revised GHS classification guidance for the Japanese government. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7 Reproductive toxicity Not classified
-
-
- - It was classified as "Not classified" because no reproductive toxicity was seen in a multi-generation reproductive toxicity test with rats, and no developmental toxicity was observed even at the doses where maternal toxicity was found in developmental toxicity tests with rats and rabbits (JMPR (2005)). The category was changed because information on reproductive/developmental toxicity was obtained. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it corresponds to "Not classified" in the oral route because no toxic signs were observed at the doses within the guidance value range in rats, mice, and hamsters (JMPR (2005)). FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9 Specific target organ toxicity - Repeated exposure Category 2 (liver)


Warning
H373 P260
P314
P501
The liver was considered to be the target organ because it is described that centrilobular hypertrophy and vacuolation of hepatocytes, focal cystic degeneration of hepatocytes, and diffuse distribution of fat deposits in the liver were observed in a 2-year diet administration test with rats (IRIS (1991)), and eosinophilia of the periportal hepatocytes was found in a 12-month diet administration test with dogs (JMPR (2005)). Besides, effects in experimental animals were seen within the guidance value range (20-36 mg/kg/day) corresponding to Category 2. From the above, it was classified in Category 2 (liver). Besides, the blood system was included in the target organ in the previous classification because a significant decrease in methemoglobin was seen, however, hemoglobin was mistaken for methemoglobin, the decrease was described to be slight, and there were no related findings. Therefore, the blood system was removed from the target organ this time. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
11 Hazardous to the aquatic environment Short term (Acute) Not classified
-
-
- - In preparation. Check the Japanese version. FY2022 GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11 Hazardous to the aquatic environment Long term (Chronic) Category 1


Warning
H410 P273
P391
P501
In preparation. Check the Japanese version. FY2022 GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12 Hazardous to the ozone layer Classification not possible
-
-
- - In preparation. Check the Japanese version. FY2022 GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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