NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7446-70-0
Chemical Name	aluminium chloride, anhydrous
Substance ID	m-nite-7446-70-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	The substance is a non-flammable solid (ATSDR (2008); Hommel (1996); ICSC (2005)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	The substance is non-flammable (ATSDR (2008); Hommel (1996); ICSC (2005)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified	- -	-	-	The substance is non-flammable (ATSDR (2008); Hommel (1996); ICSC (2005)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Its water solubility is 45.1 g/100 g H2O at 25degC (Lide (88th, 2008)) and it is stable in contact with water.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic substance	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Its rat LD50 values are 370 mg/kg bw (ATSDR (2008)), 1100 mg/kg bw (JECFA (series 24: 2007)), and 3700 mg/kg bw (JECFA (series 24: 2007)). Since the majority of these values fall under Category 4 guidance values, the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on the following information, the substance was classified into Category 1: open irritation tests using rabbits found that the substance causes severe irritation (RTECS (2008)); open irritation tests using mice found that the substance causes severe irritation (RTECS (2008)); and human tests found that the substance is corrosive (IUCLID (2000)) and causes moderate irritation (IUCLID (2000)). In addition, mild irritation was observed in humans to whom the test substance was applied for 3 days or more (HSDB (2005)). It is also reported that the use of medicine containing aluminum chloride for the treatment of hyperhidrosis worsened miliaria (HSDB (2005)). The substance is rated as C; R34 in the EU classification.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	The substance was classified into Category 1 for the following reasons: human tests found that the substance is highly corrosive (IUCLID (2000)); there are human cases of corneal burns involving the substance (HSDB (2005)); and it was previously classified into Category 1 for skin irritation / corrosion (IUCLID (2000)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	The substance was classified into "Not classified" based on the following information: Buehler tests using guinea pigs found that the substance is not sensitizing (IUCLID (2000)); maximization tests using guinea pigs found that the substance is not sensitizing (IUCLID (2000)); maximization tests on humans found that the substance is not sensitizing (IUCLID (2000)); patch tests on humans found that the substance is not sensitizing (IUCLID (2000)). On the other hand, positive reactions were found in patch tests applied to patients whose itchy dermatitis worsened by using antiperspirant containing aluminum chloride (EHC No. 194 (1997)), and in patch tests applied to children who received a shot of aluminum-bound vaccine during infancy to prevent hypersensitivity (EHC No. 194 (1997)); however, the link between the positive reaction and aluminum chloride is not clear.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	The substance was classified into Category 2 based on the positive results obtained in micronucleus tests using bone marrow cells of mice that underwent intraperitoneal administration (in vivo mutagenicity tests using somatic cells) (ATSDR (2008). In in vitro tests, positive results were obtained in chromosomal aberration tests and micronucleus tests using human peripheral lymphocytes (ATSDR (2008)) while negative results were obtained in Ames tests and mouse lymphoma assays (ATSDR (2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It is documented that no effects of the substance were detected in either 3-generation tests using rats that underwent oral administration through drinking water (19.3 mg/kg/day) (JECFA (series 24: 2007)), or developmental toxicity tests using rats that were fed with a mixed diet (91 mg/kg/day) between day 6 and 19 of the gestational period (IUCLID (2000)). However, in forced oral administration tests using mice that were applied with 41 mg Al/kg/day (202 mg AlCl3/kg/day) between day 7 and 16 of the gestational period, an increased embryo resorption was observed, while toxic effects on the parents were unclear (ATSDR (2008)). In addition, in mixed diet tests using rats that were fed with 272 mg Al/kg/day (1343 mg AlCl3/kg/day) between day 1 and 20 of the gestational period, significant impairment in the righting reflex and grasping reflex were observed in rat pups, while toxic effects on the parents were unclear (ATSDR (2008)). Moreover, in forced administration tests using rats that were applied with 900 or 1800 mg/kg on day 15 of the gestational period, significant effects were detected on timing of pinna detachment and eye opening, and learning acquisition in offspring, while toxic effects on the parents were unclear. Since exposure to the test substance during prenatal period is documented to affect development and behavior of the offspring (IUCLID (2000)), the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Although dermal toxicity tests using rabbits or mice have been documented (RTECS (2008), no descriptions of specific toxic symptoms are available other than those on irritation and inflammation in the treated area. Thus, classification is not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system)	Warning	H373	P260 P314 P501	In 60-day forced oral administration tests using rats, an increased acetylcholinestrase activity was observed in olfactory bulb, striatum and hypothalamus at the dose of 320 mg Al/kg bw (90-day conversion value: 213 mg/kg/day), which falls under the guidance values for the "Not classified" category (CaPSAR (2000)), indicating the effects of the substance on the nervous system. In 180-day tests using rats that underwent administration in drinking water, reduced spontaneous locomotor activity, impaired acquisition, extinction and reacquisition of an active avoidance task were observed at the dose of 12 mg Al/day per rat (59 mg AlCl3/day per rat), which falls under the guidance values for Category 2 (CaPSAR (2000). Furthermore, in 3-month tests using rats that underwent administration in drinking water, impairment of post-rotatory nystagmus was observed at the dose of 43.1 mg/kg/day, which falls under the Category 2 guidance values (ATSDR (2008)). Based on these results, the substance was classified into Category 2 (nervous system). Also, in 21-day forced oral administration tests using rats, a significant decrease in red blood cells, hematocrit, and serum iron concentration; an increase in platelets; and a decrease in hemoglobin were found, suggesting that exposure to aluminum may cause normocytic anemia (IUCLID (2000)). However, the exposure dose was 494 mg/kg/day (90-day conversion value: 115 mg/kg/day), which fell under the guidance values for the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 96h LC50 = 0.37 mg/L for fish (Atlantic salmon) (EHC 194 1997), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1, it is an inorganic matter, and it is not rapidly degradable, the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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