Latest GHS Classification Results by the Japanese Government (edited by NITE)

Japanese



GENERAL INFORMATION
 
Item Information
CAS RN 75-00-3
Chemical Name Chloroethane
Substance ID m-nite-75-00-3_v1
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) To Guidance List
UN GHS document (External link) To UN GHS document
FAQ（GHS classification results by the Japanese Government） To FAQ
List of Information Sources (Excel file) List of Information Sources
List of Definitions/Abbreviations Definitions/Abbreviations
Sample Label by MHLW (External link) MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) To OECD/eChemPortal (External link)

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Explosives Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2 Flammable gases Category 1


Danger
H220 P210
P377
P381
P403 		It is classified in Division 2.1 (UN 1037) in UNRTDG. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Oxidizing gases Not classified
-
-
- - It is flammable gases of Division 2.1 in UNRTDG. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5 Gases under pressure Liquefied gas


Warning
H280 P410+P403 Because a critical temperature of 187 deg C (HSDB (Access on August 2015)) is above 65 deg C, it was classified as liquefied gas (low pressure liquefied gas). FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6 Flammable liquids Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7 Flammable solids Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10 Pyrophoric solids Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11 Self-heating substances and mixtures Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14 Oxidizing solids Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15 Organic peroxides Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to gas substances are not available. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17 Desensitized explosives -
-
-
- - - - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Acute toxicity (Oral) Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Dermal) Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - There are reports that an LC50 value (4 hours) for rats was > 19,000 ppm (SIDS (2007)), and LC50 values (2 hours) for rats were 57,600 ppm (converted 4-hour equivalent value: 40,305 ppm) (PATTY (6th, 2012), DFGOT Vol.3 (1992), IARC 52 (1991)), 57,600 ppm (converted 4-hour equivalent value: 40,305 ppm) (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)), 60,632 ppm (converted 4-hour equivalent value: 42,873 ppm) (ACGIH (7th, 2001)) and 57,600-60,632 ppm (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). The category cannot be specified by the 4-hour value, but since all of the 2-hour values correspond to "Not classified," it was classified as "Not classified." FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Vapours) Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Dusts and mists) Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321 		There is a report that edema was observed in the subcutaneous tissues as a result of an application of this substance to rats (SIDS (2007)). In addition, there is a report of skin irritation in humans exposed to the vapor of this substance (SIDS (2007), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). From the above, it was classified in Category 2. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280 		There is a report that corneal opacity was observed as a result of an application of this substance to the eyes of rabbits (SIDS (2007)), but the degree of irritation is unknown. There is a report of eye irritation in humans exposed to the vapor of this substance (SIDS (2007), Initial Risk Assessment (NITE, CERI, NEDO, 2005)), and a description that this substance is irritating to the eyes (ACGIH (7th, 2001)). From the above, it was classified in Category 2. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
 FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report that a sensitization reaction was observed as a result of a patch test of this substance in two volunteers (SIDS (2007), ATSDR (1998)). However, this was judged as insufficient data to be used for classification because the details are unknown. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5 Germ cell mutagenicity Classification not possible
-
-
- - The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a micronucleus test and a chromosomal aberration test with mouse bone marrow cells were negative, and an unscheduled DNA synthesis test with mouse liver was negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), SIDS (2007), IARC 71 (1999), ACGIH (7th, 2001), ATSDR (1998), PATTY (6th, 2012)). As for in vitro, bacterial reverse mutation tests and a mammalian cell gene mutation test were positive, and DNA damage and repair tests with cultured liver cells of rats and mice were negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), SIDS (2007), IARC 71 (1999), ACGIH (7th, 2001), ATSDR (1998), DFGOT Vol.3 (1992)). FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6 Carcinogenicity Category 2


Warning
H351 P308+P313
P201
P202
P280
P405
P501 		There is no information on carcinogenicity in humans. As for experimental animals, in carcinogenicity studies in which rats and mice were exposed by inhalation at 15,000 ppm for 2 years, in rats, a slight increase in the incidence of skin tumors (male), and development (female, a few cases) of neuroglial cell tumors which are rare tumors were found, and in mice, an increase (male) in the incidence of alveolar/bronchiolar tumors, an increase (female) in the incidence of hepatocellular tumors, and an increase in uterine carcinomas were observed. Based on these results of carcinogenicity studies in experimental animals, ACGIH classified it in A3 in 1995 (ACGIH (7th, 2001)). On the other hand, IARC reassessed carcinogenicity of this substance in humans in 1999 and classified it in Group 3, stating that there is no data available in humans, and there is limited evidence in experimental animals (IARC 71 (1999)). Other than these, although the year of the classification cannot be specified, it was classified in Carc.2 in EU CLP classification (ECHA 2014 CMR Report (ECHA (Access on August 2015))). From the above, although the interpretation of the carcinogenicity test results in the experimental animals is different by the organization, the classification results by ACGIH and EU were adopted, and it was classified in Category 2 for this hazard class. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7 Reproductive toxicity Classification not possible
-
-
- - There is a report that as a result of inhalation exposure to the vapour of this substance in pregnant mice on gestational day 6-15 at 5,000 ppm (13,000 mg/m3), there was no maternal toxicity, and in fetuses, delayed ossification of the skull bones and a minimum increase in the incidence of supernumerary ribs were observed (SIDS (2007), ACGIH (7th, 2001)). However, these effects were too slight to classify as developmental toxicity effects according to the GHS classification guidance for the Japanese government, and fetal toxicity was not observed in other developmental toxicity tests with rats and mice by the inhalation route (SIDS (2007)). On the other hand, there is no result from a test in which sexual function and fertility are evaluated. Therefore, it was classified as "Classification not possible" because there are no data available for classification as a whole. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs, heart), Category 2 (liver), Category 3 (narcotic effects)



Danger
Warning
H370
H371
H336 		P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312 		This substance is irritating to the respiratory tract (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), SIDS (2007), ACGIH (7th, 2001), IARC 52 (1991), NTP TR 346 (1989), ATSDR (1998)). As for humans, it was used as an anesthetic in the past. There are reports of narcotic effects, a feeling of drunkenness, headaches, nausea, vomiting, dizziness, incoordination, loss of consciousness, central nervous system effects, hyporeflexia, stupor, stomach cramps, respiratory and cardiac disorders, lack of muscle coordination, arrhythmia, asystole, ventricular fibrillation, systolic dysfunction, myocardial depression, cardiac sensitization, tachypnea, respiratory paralysis, and respiratory failure by inhalation exposure (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), SIDS (2007), ACGIH (7th, 2001), IARC 52 (1991), NTP TR 346 (1989), ATSDR (1998), DFGOT Vol.3 (1992), PATTY (6th, 2012)).
As for experimental animals, in an inhalation exposure in guinea pigs at 20,000 ppm (corresponding to Category 2), unsteady gait, stagnation, dizziness, congestion and haemorrhage of the lung, pulmonary edema, congestion of the liver, hepatic edema, and histopathological changes (survival cases) of the liver were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), ACGIH (7th, 2001), ATSDR (1998), DFGOT Vol.3 (1992)).
Since effects on the central nervous system in humans are associated with narcotic effects (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)), the central nervous system was not adopted as the specific target organ.
From the above, this substance affects the respiratory organs, heart and liver in addition to respiratory tract irritation and narcotic effects. Therefore, it was classified in Category 1 (respiratory organs, heart), Category 2 (liver), Category 3 (narcotic effects).
Besides, as for the kidney described in the previous classification, it was not adopted due to the doses exceeding Category 2. 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system)


Danger
H372 P260
P264
P270
P314
P501 		As for humans, there is a description that neurological symptoms (ataxia, tremors, speech difficulties, slowed reflexes, nystagmus, hallucinations), and swelling and tenderness of the liver were observed in a woman who abused 200-300 mL/day of this substance by inhalation for 4 months (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), PATTY (6th, 2012)). In addition, there is a description that neurological symptoms (short-term memory loss, visual hallucinations, lower limb neuropathy) were observed in a man who inhaled approximately 100 mL of this substance every day for 4 months, but there was no description of the effects on the liver (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), PATTY (6th, 2012)). On the other hand, as for experimental animals, although there are reports of tests with rats, mice, rabbits and dogs exposed to this substance by inhalation for 2-26 weeks, only an increase in relative liver weight was observed at the doses (4,000-19,000 ppm/6 hr) far beyond Category 2, and there were no findings by which target organs could be identified (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)).
From the above, the onset of neurological symptoms due to exposure to this substance in humans is considered to be certain, but as for effects on the liver, there was a finding only in one case, and it was considered that since the information on it was insufficient, the liver could not be adopted as the target organ. Therefore, it was classified in Category 1 (nervous system) for this hazard class. 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10 Aspiration hazard Not classified (Not applicable)
-
-
- - Gas (GHS definition) FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
11 Hazardous to the aquatic environment Short term (Acute) Category 3
-
-
H402 P273
P501 		From 48-hour EC50 = 58 mg/L for crustacea (Daphnia magna) (SIDS, 2003, Initial Risk Assessment (NITE, CERI, NEDO, 2005)), it was classified in Category 3. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11 Hazardous to the aquatic environment Long term (Chronic) Category 3
-
-
H412 P273
P501 		Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (a degradation rate by BOD: 1% (Official Bulletin of Ministry of International Trade and Industry, 1991)), and acute toxicity Category 3, it was classified in Category 3. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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