NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	75-77-4
Chemical Name	Chlorotrimethylsilane
Substance ID	m-nite-75-77-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Classified into Category 2 (>35 degC) since flash point is -28 degC (Closed-cup) (Hommel (1996)) and -18 degC (Chapman (Ver. 17.1, 2009)), and initial boiling point is 57 degC (Chapman (Ver. 17.1, 2009)). The substance is classified into Class 3, PG II in UNRTDG (UN1298).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Auto-ignition point is 395 degC (ICSC (J) (2002)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Classified into Not classified since the substance contains metalloids (Si) and explosively decomposes on contact with water (IUCLID (2000)), but gas formed is not combustible hydrogen chloride (ICSC (J) (2002)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified	- -	-	-	Classified into Not classified since information is available that the substance contains chlorine (but not oxygen or fluorine) bonded to metalloids and is "Not oxidizing agent" (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Information is available that the substance attacks many metals in presence of water (ICSC (J) (2002)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on a LD50 value of 100 - 300 mg/kg bw for rats (vehicle: olive oil) (IUCLID (2000)), the substance was classified into Category 3. As relevant information, there are LD50 values of 4868 mg/kg and 5700 mg/kg when diluted in Silicone L-45 oil (HSDB (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	Based on a LD50 value of 1500 - 2000 mg/kg bw for rats (IUCLID (2000)), the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on the LC50 value of 1498 ppm/4h for rats (OECD TG403) (IUCLID (2000)), the substance was classified into Category 3. Since the LC50 value was lower than 90% of saturated vapour pressure concentration (307,895 ppm), the substance was determined as "vapour with almost no included mists", and classification criteria for gas was adopted.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There is a report of "Necrosis, accompanied by severe erythema, moderate edema, and desquamation was observed within 1-hour after application of 0.5 mL to the skin of rabbits for 4-hour. The effects persisted through 1-week observation period. Although the skin primary irritation index was 2.2/8.0 (HSDB (2007)), the substance was classified into Category 1 based on a report of "highly corrosive" in another rabbit test (IUCLID (2000)) and a report of "corrosive to the skin" (HSDB (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Although there is a report of "corneal injury, iritis, and moderate to severe conjunctivitis with necrosis observed after application of 0.005 mL undiluted substance to the eye of rabbits with a maximum mean Draize score of 31.5/110" (HSDB (2007)), the substance was classified into Category 1 based on a report of "highly corrosive" in another rabbit test (IUCLID (2000)) and another report of "corrosive to the eye" (HSDB (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in a rat bone marrow chromosome aberration test (in vivo somatic cell mutagenicity tests) (IUCLID (2000)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there are reports of negative in almost all Ames tests (NTP DB (access on Aug. 2009)), and equivocal in mouse lymphoma chromosomal aberration test ((IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic, respiratory system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	After oral administration of 172 - 688 mg/kg to rats, sluggishness, dyspnea and prostration were observed, and death followed within 30 minutes to two days. At necropsy, red to black stomachs and intestines, blanched livers, black stomach contents and red fluid in thoracic cavities were seen (HSDB (2007)). After exposing rats to vapour concentration of 10.414 - 16.840 mg/L, the animals of the highest concentration group died, and survivors showed nasal crust, rough coat and decreased body weight gain. At necropsy, major findings included corneal opacity and diffuse or focal dark coloured areas of the lungs (HSDB (2007)). After dermal application of 860 - 3440 mg/kg to rabbits, systemic effects including sluggishness, unsteady gait, and diarrhea were observed and death occurred at 30 minutes to eight days. At necropsy, livers with pink to dark red areas were seen (HSDB (2007)). The toxic signs and pathological findings were observed at dose levels within the guidance value range for Category 2 by oral, dermal and inhalation route, but the affected organ could not be identified. Therefore, the substance was classified into Category 2 (systemic toxicity). In addition, as human effects, there are reports that inhalation of vapour irritates mucous membranes and cause severe irritation of throat (HSDB (2007)) and that the substance and its vapour are corrosive to the respiratory tract and may cause lung edema. Additionally, symptoms by inhalation include burning sensation, cough, sore throat, labored breathing, shortness of breath (HSDB (2007)). Based on this information reported in a document in List 2, the substance was classified into Category 2 (respiratory system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Although there is a result that no toxic effects were observed by inhalation exposure of 34 ppm (0.151 mg/L) to rats for 2 weeks (IUCLID (2000)), the tested dose level is under the upper limit of the guidance value range for Category 1 (50 ppm), therefore, classification was not possible due to lack of data	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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