NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	760-23-6
Chemical Name	3,4-Dichloro-1-butene
Substance ID	m-nite-760-23-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point reported 33 degC (closed-cup) (IUCLID (2000)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Although there are chemical groups (an unsaturated bond) present in the molecule associated with self-reactive properties, classification is not possible due to lack of additional data.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	There is a description, "Flammability: 2 (This degree includes materials that must be moderately heated before ignition will occur)" (HSDB (2003)). It is considered that the substance is not pyrophoric at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine which is chemically bonded only to carbon.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	The rat LD50 values of 943 mg/kg (male), 946 mg/kg (female) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council (1996)), 879 mg/kg (SIDS (2001)) and 577 - 1153 mg/kg (SIDS (2001)) were documented. These all data are corresponded to Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	The rabbit LD50 value of > 2000 mg/kg and no mortality was reported (SIDS (2001)). The substance was classified as "Not Classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on the rat LC50 value of 2100 ppm/4hrs (SIDS (2001)), the substance was classified as Category 3. Since the LC50 value was lower than 90% of the saturated vapor pressure concentration (28816 ppm), the criterion values for gas were adopted for the classification.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	In the 4-hour rabbit test (OECD TG404, GLP-compliant), application of 0.5 ml of the undiluted test substance for three animals caused slightly irritating with erythema (grade 1 or 2) until 72 hours after removal of patch in all animals. And the mean scores of erythema or edema at 24, 48 and 72 hours after removal of the patch were less than 2.3 (SIDS (2001)). Based on the document, the substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	In the rabbit test (OECD TG 405, GLP-compliant), instillation of 0.1ml of the undiluted test substance to conjunctival sac for three animals caused corneal opacity (grade 1) and iritis (grade 1) in 1 animal at 1-48 hours after instillation, and conjunctival redness (grade 1) in all three animals at 1 hour after instillation. Therefore, this substance was judged to be slight irritant. The mean scores of corneal opacity and iritis after 24, 48 and 72 hours of instillation was both 0 in 2 of 3 animals and those of conjunctival redness and edema were both under 2 in all 3 animals (SIDS (2001)). Based on the document, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	In the guinea pig test, the substance was reported as not sensitizing (SIDS (2001)). However, because the details containing test methods were unknown, the substance was classified as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	The classification was concluded as Category 2 based on the positive results in the chromosomal aberration test using bone marrow cells obtained from the rats that were exposed by inhalation (in vivo mutagenicity test in somatic cells) (SIDS (2001)). As relevant information, as for in vitro mutagenicity studies, positive results in the Ames test, the chromosome aberration test using CHL/IU cells ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (1996)) and the HGPRT gene mutation assay using CHO cells (SIDS (2001)) were reported.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant), no adverse effects were documented on sexual functions and fertility containing the copulation index, fertility index, gestation length, gestation index and state of lactation in maternal animals. No treatment-related effect on the number of offspring and live pups, sex ratio, live birth index, viability index and morphological findings were detected in any of the offspring ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (1996)). However, since the inspection for the fetal developmental at the end stage of gestation period was not performed, data were insufficient. Therefore, the substance was classified as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (liver), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In the single inhalation study in rats exposed to vaporized test substance to 3000 ppm/4hrs (15.3 mg/L/4hrs), dead animals the day of exposure showed centrilobular reduction of hepatocellular glycogen and fatty change. Even in the rats exposed to 1000 ppm/4hrs (5.11 mg/L/4hrs), equivalent to Category 1 of the guidance values, progress of liver lesions that led to centrilobular necrosis were observed after one day of exposure ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (1996)). Based on these findings, the substance was classified as Category 1(liver). Moreover, in the acute oral toxicity study in rats (LD50 value: 943-946 mg/kg), clinical signs observed after administration included decreased locomotor activity, deep respiration, ptosis, salivation, muscular relaxation, prone position, piloerection, etc. (SIDS (2001)). In another acute oral toxicity study in rats (LD50 value: 577-1153 mg/kg), the signs of weakness and narcotic symptoms were reported (SIDS (2001)). Further, clinical signs containing indifference to auditory and tactile stimuli in the acute dermal study (LD50 value: > 2000 mg/kg), as well as incoordination and refractory in the acute (vapor) inhalation study (LC50 value: 2100 ppm/4hrs (10.7 mg/L/4hrs)) were documented (SIDS (2001)). Based on the information, the substance was classified as Category 3 (narcotic effects).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver)	Danger	H372	P260 P264 P270 P314 P501	In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (1996)), increase in the liver weight and hypertrophy of hepatocytes were observed at 50 mg/kg/day (converted dose level as that of 90-day study: approx. 23 mg/kg/day). In the 6-month oral toxicity study in rats, degenerative changes in the liver were also reported (SIDS (2001)). Furthermore, it was described that exposure of the vapor of the substance to rats for 2 weeks at 1.037 mg/L/6hrs (converted value as that of 90-day study: 0.161 mg/L/6hrs) revealed increased relative liver weight and morphological changes in liver, and essential toxicity was hepatocellular hypertrophy (SIDS (2001)). Based on the findings described above, since the effect concentration in inhalation study was equivalent to Category 1 within the guidance values, the substance was classified as Category 1 (liver).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Classified into Category 2 from its 48h-EC50 = 10 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1996).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (28d-BOD degradation rate = 1 - 28% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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