NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7631-95-0
Chemical Name	Sodium molybdate
Substance ID	m-nite-7631-95-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water from water solubility data measured. water solubility: 650 g/L (20 degrees C) (GESTIS (Access on September 2015))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound that contains oxygen, but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	From a reported LD50 value of 250 mg/kg for rats (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)), it was classified in Category 3.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, the category cannot be determined only from a reported LC50 (4 hours) of > 2,08 mg/L for rats (GESTIS (Access on September 2015)). A reference value of dust/mists was used because a test substance is a solid.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It is written that this substance shows severe irritation to the skin (HSDB (Access on September 2015)) and that primary irritation was shown 24 hours after application but resolved within 72 hours (PATTY (6th, 2012)). From the information of severe irritation, it was classified in Category 2.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It is written that this substance shows irritation to eyes (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on September 2015)) and that conjunctival redness were observed after an application of a 20% solution of this substance (PATTY (6th, 2012)). From the above, it was classified in Category 2.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is written that this substance does not show sensitization (PATTY (6th, 2012)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, a mouse dominant lethal test and a micronucleus test in mouse bone marrow cells were positive (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ACGIH (7th, 2003)). As for in vitro, a micronucleus test in human lymphocytes was positive (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ACGIH (7th, 2003)). Because the positive result the mouse dominant lethal test is unclear, based on the positive result of the micronucleus test in mouse bone marrow, the substance was classified in Category 2 in accordance with the Guidance.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	There is no carcinogenicity information on this substance itself, but it is thought that the information on soluble molybdenum compounds is usable as shown below. As for humans, in a case-control study on workers who handled molybdenum compounds over 21 years, as a result of an investigation of correlation between exposure to molybdenum and a lung cancer incidence, for chromium and mineral oils to which they were exposed simultaneously, there is no correlation between an exposure period and a lung cancer incidence, and only exposure to molybdenum shows a dose-response relationship, and an increased risk of lung cancer by molybdenum exposure was reported for the first time (ACGIH (7th, 2003)). As for experimental animals, in a carcinogenicity test in which rats or mice were exposed by inhalation to molybdenum trioxide that is a soluble molybdenum compound for 2 years, an increased trend of incidences of alveolar/bronchiolar adenoma and cancer (combined) in male rats, an increased incidence of alveolar/bronchiolar cancer, and alveolar/bronchiolar adenoma and cancer (combined) in male mice, and increased incidences of alveolar/bronchiolar adenoma, and alveolar/bronchiolar adenoma and cancer (combined) in female mice were observed. Therefore, concerning weighing of evidence for carcinogenicity, it is concluded in NTP that there is equivocal evidence in male rats and some evidence in male and female mice (NTP TR 462 (1997)). As a carcinogenicity classification result by other organization, ACGIH classified soluble molybdenum compounds in "A3" because further investigation is needed to verify only one human epidemiological study reporting an increased risk of lung cancer although soluble molybdenum compounds surely show carcinogenicity in experimental animals (ACGIH (7th, 2003)). Besides this, there is no classification result by the international organization. As above, because this substance corresponds to a soluble molybdenum compound, it is thought that Category 2 is adequate in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is no information on reproductive effects in humans. As for experimental animals, it is written that female rats were given dihydrate of this substance in drinking water for six weeks, and a part of animals was slaughtered at that time, and the rest was mated with untreated males and kept dosing until day 21 of gestation in a test. A prolongation of sex cycle was observed in groups of 10 ppm (converted to this substance equivalent: 3.4 mg/kg/day) or higher at the end of 6-week exposure, and maternal animals showed weight gain reduction, lower fetal weight, lower trend in fetus number, increased resorptions, and delayed organ development in fetuses at 10 ppm or above in a group dosed during a gestation period (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). It is written that after 13-week diet administration with dihydrate of this substance, male and female rats were mated, a decreased fertility index was observed at doses of 80 ppm (about 8 mg/kg/day) or higher. Males of sterile pairs were mated with untreated females, but pregnant females were not obtained, and atrophy of seminiferous tubule was observed histologically in testis (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). Besides these, it is also written that in a test in which mice were given a soluble molybdenum compound (a name of the substance is unknown) in drinking water for a period of over six months throughout three generations, increased early deaths in the offspring of F1 and F3 generations, increased mortality of F3 maternal animals, and growth inhibition in F3 offspring were shown in a dosed group (10 ppm) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); DFGOT vol. 18 (2002)). As above, for soluble molybdenum compounds including this substance, from the test results using experimental animals, reproductive/developmental toxicity was observed at the doses where general toxicity effects of molybdenum were mostly found in parent animals. Therefore, the substance was classified in Category 2 for this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Aerosol of this substance is irritating to the respiratory tract, and cough and pharyngalgia in inhalation, and abdominal pain, nausea, vomiting, and diarrhea in oral digestion were reported (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). From the above, it was classified in Category 3 (respiratory tract irritation).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (systemic, testis), Category 2 (kidney)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	No human data. As for experimental animals, in a test in rats in 4-week diet administration of disodium molybdate dihydrate (CAS number: 10102-40-6), besides deaths, extreme emaciation and decreased body weight caused by increased excretion of copper from bodies due to molybdenum administration were observed, and results of necropsy and blood test were within a normal range. At 0.05% (about 25 mg/kg/day) (converted to a 90-day equivalent: 7.78 mg/kg/day) of the lowest dose of this test, decreased body weight was found. (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) In a test in rats in 13-week diet administration of disodium molybdate dehydrate, degeneration of seminiferous tubule in testis were observed in males at 0.008% (8 mg/kg/day) within a range of Category 1 (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). Moreover, in a test in rats in 90-day gavage administration of disodium molybdate dehydrate, weight gain reduction and slight diffuse hyperplasia of proximal tubule were found at 60 mg/kg/day within a range of Category 2 and reversibility was observed (SIDS/SIAP (2013)). As above, deaths, extreme emaciation, and decreased body weight for which target organs could not be specified were regarded as systemic effects and observed within a range of Category 1. Moreover, effects on testis were found within a range of Category 1, and effects on kidney were observed within a range of Category 2. Therefore, the substance was classified in Category 1 (systemic toxicity, testis), Category 2 (kidney).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	From 96-hour LC50 = 2650 mg Mo/L for for crustacea (Crangonyx pseudogracilis) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012) and 96-hour LC50 = 800 mg Mo/L for fish (Oncorhynchus mykiss) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Although the behavior in water is unknown due to a metal compound, from 7-day NOEC (growth rate) = 24.7 mg Mo/L for monocotyledonous plant (Lemna minor), 21-day NOEC (reproduction) = 50 mg Mo/L for crustacea (Daphnia magna), 1-year NOEC (lethal, growth) >= 17.0 mg Mo/L for fish (Oncorhynchus mykiss) (all Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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