NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7637-07-2
Chemical Name	Trifluoroborane
Substance ID	m-nite-7637-07-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified	- -	-	-	It is not combustible (ICSC (J) (1993)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	From a boiling point of -100 deg C (ICSC (J) (1993)), and a critical temperature of -12.25 deg C (Hommel (1991)), it was classified as high pressure liquefied gas. It is classified in Division 2.3, Subsidiary Risk 8 in UNRTDG (UN 1008).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available. Besides, there is the information that it attacks many metals when dissolved in water (ICSC (J) (1993)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on an LC50 value of 436 ppm for rats (ACGIH (7th, 2001), DFGOT Vol. 13 (1999), PATTY (6th, 2012)), this substance was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is described that it is severely irritating or corrosive to human skin (ACGIH (7th, 2016), ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH), 1979)). In addition, this substance was classified as "Skin. Corr. 1A H314" in EU CLP classification (ECHA CL Inventory (Access on May 2017)). From the above, this substance was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on the description that it is severely irritating to human eyes (ACGIH (7th, 2016), OEL Documentations (Japan Society For Occupational Health (JSOH), 1979)), this substance was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, fluorides were classified in A4 by ACGIH (ACGIH (7th, 2001)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory organs, cardiovascular system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In humans, there is a description that this substance is irritating to the lungs and mucous membranes, and severe exposure leads to pulmonary inflammation and congestion and collapse of the circulatory organ system (cardiovascular system) (HSDB (Access on May 2017)). As for experimental animals, in a 4-hour single inhalation exposure test at 26.8 ppm, which is within the guidance value range for Category 1, ventral cartilage necrosis, hemorrhage, and ventral epithelial hyperplasia, and inflammatory cell infiltration in the larynx and trachea were observed in 24 hours after exposure (HSDB (Access on May 2017)). From the above, this substance was classified in Category 2 (respiratory organs, cardiovascular system). Since HSDB is an information source in List 2, it was classified in Category 2. Besides, in the previous classification, based on the information that there is description of effects on the nervous system in human (hyporeflexia, drowsiness, syncope, decrease in blood pressure, hyperpnea and respiration depressed) (ICSC (J) (1993), HSDB (2005)), it was classified in Category 3 (narcotic effects). However, because there was no description of the above mentioned symptoms in ICSC (J) (1993), and the description of the above mentioned symptoms in HSDB (Access on May 2017) was not for this substance but for effects by oral ingestion of fluorides, it was not adopted. Since there is no other information on the evidence for narcotic effects, the classification result was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, kidney, bone)	Danger	H372	P260 P264 P270 P314 P501	In humans, there is no clear information on this substance. However, there is a report of lesions in bones related to fluorosis due to occupational exposure to inorganic fluorides in ACGIH's "FLUORIDES" (ACGIH (7th, 2001)). As for experimental animals, though there is no reliable data on this substance, it is thought that data on the dihydrate are available. There is a report that in a 13-week (6 hours/day, 5 days/week) test in which rats were exposed by inhalation to the dihydrate (aerosol), rales, lacrimation and necrosis of the proximal tubules were observed at 17 mg/m3 (converted guidance value: 0.012 mg/L), which is within a guidance value range for Category 1 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol. 14 (Ministry of the Environment, 2016), PATTY (6th, 2012), ACGIH (7th, 2016)). Besides, other than this, in humans, according to the survey results from health examinations started in 1974 for a small group (7 being exposed, 6 with exposure in the past) which had been exposed to this substance and other fluorides for 1 to 27 years in a manufacturing plant in USA, there is a report of a decrease in pulmonary function (vital capacity and 1-second volume) in 5 out of 7 being exposed and 3 out of 6 with exposure in the past, but it is reported that the X-ray examinations were negative, and no urinary fluorine concentration was above 4 mg/L which is an acceptable concentration at the end of a working time (HSDB (Access on May 2017)). In addition, in Soviet report (Summary Document) on 78 workers who had been exposed to this substance for 10 to 15 years, there is a report of dryness and bleeding of the nasal mucosa, bleeding gums, dryness and desquamation of the skin, and pain in joints. However, specific exposure concentrations were not reported and there was no report on the concentrations of ethylene and isobutylene that they were exposed to concurrently (HSDB (Access on May 2017)). This information was not adopted as evidence for classification because it is considered to be insufficient. Therefore, this substance was classified in Category 1 (respiratory organs, kidney, bone). As for the information on humans which was used in the previous classification, ICSC (J) (1993) is information sourced in List 3, the description in HSDB (2005) was not used for the classification because the content was confirmed and then found to be insufficient as described above, and IUCLID (2000) cannot be confirmed. Therefore, the classification result was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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