NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	764-41-0
Chemical Name	2-Butene, 1,4-dichloro-
Substance ID	m-nite-764-41-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point 59 degC (closed-cup) (Gangolli (2nd, 1999)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Classification is not possible since no data are available though it contains chemical groups (unsaturated bonds) associated with self-reactive properties in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	The rat LD50 values of 89 mg/kg bw (ACGIH (2001) and SIDS (2006)), 220 mg/kg bw (SIDS (2006)) and 120 - 300 mg/kg bw (SIDS (2006)) were reported and all of them corresponded to Category 3. Therefore, the substance was classified as Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on the rabbit LD50 value of 735 mg/kg bw (ACGIH (2001), SIDS (2006)), the substance was classified into Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	The rat LC50 values of 0.45 mg/L/4hrs (86 ppm/4hrs) (SIDS (2006) and ACGIH (2001)) and 1.35 mg/L/4hrs (264 ppm/4hrs) (SIDS (2006)) were reported, and they correspond to Category 1 and Category 2, respectively. Selecting the category of greater hazard, the substance was classified as Category 1. The test concentration (86 ppm) was lower than 90% of the saturated vapor pressure concentration (3950 ppm), the test substance was treated as "vapor hardly coexisting mists" and the criterion values for gas were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	The treatment of the forearms of human volunteers for 0.5 to 1 hour with the undiluted substance caused marked erythema, edema, and development of blisters (SIDS (2006)). Liquid and vapors of the substance caused extremely corrosive to human skin (SIDS (2006)). Based on the information, the substance was classified as Category 1.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	The substance was classified as Category 1 based on the document that application of one drop of the substance to rabbit eye led to severe burns of the cornea and permanent damage, the substance was judged as severe eye irritant (ACGIH (2001)). As relevant information, it was reported that liquid and vapors of the substance were extremely irritating to human eyes (SIDS (2006)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Positive results were reported in the chromosome aberration test using bone marrow of rats by the inhalation exposure (in vivo mutagenicity test in somatic cells) (SIDS (2006)). Positive results were also indicated in the dominant lethal test using rats by oral or inhaled administration for 2.5 months (in vivo mutagenicity test in germ cells) (SIDS (2006)), but information on the testing method and detail of results were unknown. From the results mentioned above, effects of this substance on the somatic cells were clear, however, findings of effects on germ cells were insufficient. Therefore, the substance was classified as Category 2 based on the positive results of the chromosome aberration test of rats (in vivo mutagenicity test in somatic cells) described above. As relevant information, negative results were reported in the micronucleus test using rats by 2-week inhalation exposure (in vivo mutagenicity test in somatic cells) (OECD TG474, GLP-compliance) (SIDS (2006)). As for in vitro studies, positive results were reported in the Ames test and the gene mutation test using CHO cells (SIDS (2006), NTP DB (Access on Jan. 2011)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	The substance was classified as Category 1B based on "A2" judgment in the carcinogenicity criteria of the ACGIH (ACGIH-TLV (2006)) and "Category 2" in the EU (EU Annex 1 (2006)). As relevant information, the substance was classified as "Group 3" by the IARC assessment (IARC 71 (1994)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the developmental toxicity study in rats by inhalation exposure during the organogenetic period, no adverse effects were observed in reproductive index and development of the fetus in the high dose group that maternal body weight gain was significantly reduced. Thus, this material was judged to show neither the embryotoxic nor teratogenic potential (SIDS (2006)). On the other hand, it was reported that in the oral or inhalation studies in male rats for 2.5 months, in addition to abnormalities and necrosis in the cells of the spermatogenic epithelium were observed, increased preimplantation mortality of embryos after mating of treated males with untreated females (SIDS (2006)). However, it was reported that detail of the test method and result were not mentioned and the documentation was insufficient for assessment (SIDS (2006)). Therefore, since data on sexual functions and fertility were insufficient, and no data on exposure for females were available, the substance was classified as "Classification not possible". As relevant information, in another study, an increase in the incidence of postimplantation death was reported for rats that inhaled during the pregnancy, however, this data was concluded as insufficient for assessment (SIDS (2006)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, nervous system, systemic), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In addition to occurrence of deaths, toxic symptoms containing spasm, inappetence and weakness were observed in the acute oral toxicity study in rats at the dose levels of 119 and 297 mg/kg. Moreover, clinical symptoms consisting of spasm with gasping and flaccid paralysis were observed in the acute vapor inhalation toxicity study in rats at the concentration of 47 mg/L (SIDS (2006)). Since the exposure amounts in either study were equivalent to Category 1 of the guidance values, the substance was classified as Category 1 (nervous system). Further, in the acute inhalation (as vapors) study in rats, occurrence of deaths, irregular respiration, lacrimation and salivation were observed at the concentrations 0.364 mg/L and above, and lesions and hemorrhages in the lungs and trachitis were noted in histopathological examinations (SIDS (2006)). In another acute inhalation (as vapors) study in rats, marked reduction in respiratory rate was observed at 0. 15 mg/L and above, and the damage of epithelium of bronchus was found at 2.13 mg/L/30 min (0.74 mg/L/4hrs) and above, respectively (SIDS (2006)). All of the effective doses corresponded to Category 1 of the guidance values, thus the substance was classified as Category 1 (respiratory system). Furthermore, in the inhalation studies described above, cell degenerations in the liver, spleen, thymus and lymph nodes, or renal damage were observed concurrently (SIDS (2006)). Based on the information, since the effects by administration of the substance might extend systemically to the multiple organs, the substance was classified as Category 1 (systemic toxicity). Additionally, it was reported, in the human case, that depression of central nervous might occur by the exposure via oral and inhalation at low concentration, and coma might occur rapidly in inhalation at high concentrations (HSDB (2006)). Thus, the substance was classified as Category 3 (narcotic effect).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system)	Danger	H372	P260 P264 P270 P314 P501	In the 4-week inhalation study in rats exposed by vapors, concentration dependent effects on respiratory epithelium were observed, and inflammations and focal ulcerations were noted in mucous membranes of the nasal to respiratory tract and bronchi in the treatment groups at 8 and 12 ppm/6hrs (converted dose level as that of 90-day study: 0.014 and 0.021 mg/L/6hrs) (SIDS (2006), ACGIH (2001)). In another rat inhalation study exposed by vapors for up to 19 months, hyperplasia of basal cell in the nasal cavity and focal atrophy in the mucous membranes of the nasal cavities were observed in the group at 1 ppm/6hrs (0.0052 mg/L/6hrs) after 3 months of exposure (SIDS (2006)). As mentioned above, since the dose levels were all within Category 1 of the guidance values, the substance was classified as Category 1 (respiratory organ system). Besides, the effects on the liver were reported in the 26-week oral study in rats (RTECS (2009)). However, this information was not adopted as the evidence to classify due to information from the "List 3" information source designated in the GHS classification guidance for the Japanese government with its details unspecified.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 96h-LC50 = 0.42 mg/L for fish (Lepomis macrochirus) (IUCLID, 2000).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is estimated not to be rapidly degradable (28 days degradation rate tested by OECD TG305D = 0% (IUCLID, 2000)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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