NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7646-85-7
Chemical Name	Zinc chloride
Substance ID	m-nite-7646-85-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (2002)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (2002)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2002)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information on water solubility: 432 g/100 g (25 deg C) very good (ICSC (2002)), it is recognized that it does not react vigorously with water.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	The classification was not possible due to no data from the prescribed test.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 from LD50 for rats of 1,100 mg/kg bw (EU-RAR (2004), DFGOT vol. 18 (2002)) and 350 mg/kg bw (EPA Pesticides (1992)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the result in IUCLID, which was the rationale for classification in the previous classification, was LDLo and was not adopted.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In primary skin irritation tests with rabbits, after open or occlusive application of 0.5 mL of this substance (1% suspension in deionized water) to the dorsal skin, severe irritation was observed in all animals (4/4) in both tests. In the open application test, parakeratosis, hyperkeratosis and inflammatory changes in the epidermis and superficial dermis and acanthosis of the follicular epithelia were observed, and in the occlusive application test, erythema and ulceration were also found (EU-RAR (2004)). It is described in EU-RAR (2004) that this substance is classified as corrosive to the skin according to the EC criteria, and it is concluded that although the test was not according to the guidelines, the results justify classification and labeling (R34). This substance is classified in "R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There are two cases of persons who were accidentally exposed to concentrated zinc chloride in their eyes (EU-RAR (2004)). It is described that they developed edema followed by permanent cornea scarring, and recovery required 6-28 weeks (EU-RAR (2004)), and this substance is a corrosive substance. It was classified in Category 1 based on the above.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Occupational asthma by soldering fluid is reported in humans (DFGOT vol. 18 (2002)), but the cause is unknown because they were also exposed to ammonium chloride. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. A positive result is reported in an in vivo chromosomal aberration test with mouse bone marrow on zinc chloride, but a chromosomal aberration test, a micronucleus test, and a dominant lethal test with mice or rats using higher doses of zinc sulfate were negative, and the biological activities of zinc compounds are thought to be caused by zinc cation. Based on the weight of evidence, zinc chloride is not regarded as genotoxic in vivo (EU-RAR (2004)). Besides, as for in vitro, it is reported that it was negative in a bacterial reverse mutation test, negative in a chromosomal aberration test with human lymphocytes, and positive in a micronucleus test with human lymphocytes at an extremely high dose (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EU-RAR (2004), EHC (2001)). Besides, in the previous classification, chromosomal aberration tests with rats and mice (in vivo somatic cell mutagenicity test) were regarded to be positive, but they were not judged to be positive this time because their reliability is questioned in EU-RAR (2004) and EHC (2001).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because the US EPA classified it in I (IRIS (2005)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in a reproductive toxicity test with mice, reproductive toxicity (decreases in gestation rate, the number of offspring born, and live birth index) was observed, but maternal toxicity was severe because 2-5 out of 10 maternal animals died, and decreased weights of the liver and spleen were found (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Therefore, it was not used for classification.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In humans, it is reported that inhalation exposure to the fume of zinc chloride caused transient respiratory tract irritation symptoms and severe respiratory disorder (chronic lesions) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Furthermore, it is reported that soldiers were exposed by inhalation to zinc chloride during training, and some of them developed severe acute adult respiratory distress syndrome (ARDS) and died (PATTY (6th, 2012)), and it is described that fatal cases of respiratory disorder were observed including the people who developed interstitial pulmonary fibrosis by inhalation exposure and died of respiratory failure. Therefore, it was classified in Category 1 (respiratory organs). As for the liver and pancreas adopted as the target organs in the previous classification, it was impossible to identify the corresponding knowledge in EHC 221 (2001). And the other assessment documents (EU-RAR (2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), etc.) did not have such a description, therefore these were removed from the target organs.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Mouse data in DFGOT vol. 18 (2002) adopted in the previous classification are not data of inhalation exposure to zinc chloride alone but data of inhalation exposure to the mixture of many compounds including hexachloroethane, potassium nitrate, and zinc oxide, therefore it is not appropriate to use it for classification. There are no reliable data on repeated exposure to zinc chloride alone in the other assessment documents (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EU-RAR (2004)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 72-hour EC50 = 0.065 mg Zn/L for diatoms (Nitzschia closteium) (a converted value equivalent to this substance: 0.135 mg/L) (EHC 221, 2001, Initial Risk Assessment (NITE, CERI, NEDO, 2008)), it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	It was classified in Category 1 due to unknown behavior of the metal compound in water, and 72-hour NOEC = 15.6 micro gZn/L (a converted value equivalent to this substance: 32.5 microg/L) for algae (Pseudokirchneriella subcapitata) (EU-RAR, 2010).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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