NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7718-54-9
Chemical Name	Nickel (II) chloride
Substance ID	m-nite-7718-54-9_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	Not combustible (HSDB (2006))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (HSDB (2006))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (HSDB (2006))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable against water (water solubility 642 g/L (20 degC), Merck (13th, 2001)). Not reactive with water (Weiss (2nd, 1986)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance is inorganic compound containing chlorine.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on (1) to (3), it was classified in Category 3. Besides, based on the converted value equivalent to nickel chloride, the classification result was changed. [Evidence Data] (1) LD50 (Nickel Chloride Hexahydrate (CAS RN: 7718-54-9)) for rats (females): 210 mg/kg (converted value equivalent to nickel chloride: 115 mg/kg) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2017), Hazard Assessment Report (CERI, NITE, 2008)) (2) LD50 (Nickel Chloride Hexahydrate) for rats (males): 175 mg/kg (converted value equivalent to nickel chloride: 95.4 mg/kg) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2017), Hazard Assessment Report (CERI, NITE, 2008)) (3) LD50 (Nickel Chloride Hexahydrate) for rats (females): 500 mg/kg (converted value equivalent to nickel chloride: 273 mg/kg) (OECD TG 425) (AICIS IMAP (2014), EU EFSA (2018)) [Reference Data, etc.] (4) This substance was classified in Category 3 in the EU CLH.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 2. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) LC50 (Nickel Chloride Hexahydrate (CAS RN: 7718-54-9), 4 hours) for rats (males): 0.593 mg/L (converted value equivalent to nickel chloride: 0.323 mg/L) (OECD TG 403, GLP) (REACH registration dossier (Accessed Jan. 2022)) (2) LC50 (Nickel Chloride Hexahydrate, 4 hours) for rats (females): 0.746 mg/L (converted value equivalent to nickel chloride: 0.407 mg/L) (OECD TG 403, GLP) (REACH registration dossier (Accessed Jan. 2022))	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	No animal test data are available. When aqueous solutions of nickel chloride were applied, the threshold concentrations for irritancy in humans were 1% with occlusion and 10% without occlusion (EHC No. 108 (1991)). In EU classification, the substance is classified into Xi; R38. Based on these data, the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Since nickel and its compounds are classified into R42/43 in EU classification (EU-Annex I (access on Jan. 2009)), Category 2 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and respiratory tract sensitizer in DFG (MAK/BAT No.43 (2007)), the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Positive results are reported in maximization test and Polak test with guinea pigs (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 115 (2008)). In addition, nickel and its compounds are classified into R42/43 in EU classification, Category 1 for skin sensitizer in Japan Society For Occupational Health (JSOH), (Recommendations for allowable concentrations (2008)) and skin sensitizer in DFG (MAK/BAT No. 43 (2007)). Based on these data, the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results in rat and mouse dominant lethal tests (EHC 108 (1991)) and 2 mouse bone marrow micronucleus tests (EHC 108 (1991)), the substance was classified as "Not classified". As relevant information, positive results are reported in a Chinese hamster bone marrow chromosomal aberration test and a mouse bone marrow chromosomal aberration test (IARC 49 (1990), ATSDR (2005)). From in vitro mutagenicity tests, there are reports of positive gene mutation tests using Chinese hamster V79 cells and CHOAS52 cells, a negative CHO cell gene mutation test, a positive mouse lymphocyte gene mutation test, a negative Ames test, and a positive CHO cell chromosomal aberration test (IARC 49 (1990), ATSDR (2005), EHC 108 (1991), ECETOC TR. 33 (1989)). In addition, there are reports of positive mouse Fm3A breast cancer cell chromosomal aberration tests (IARC 49 (1990), EHC 108 (1991)) and a positive human peripheral lymphocyte chromosomal aberration test (EHC 108 (1991)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Based on the classifications of "Group 1" in IARC (IARC 49 (1999)), "Category 1" in EU classification (EU-Annex I (2009)), "1" in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and "K" in NTP (NTP RoC (11th, 2005)), the substance was classified into Category 1A. In an intramuscular administration test in rats, tumor development was not observed (IARC vol. 49 (1990)). In an oral test in male rats, the substance is concluded to be a promoter of kidney cancer (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 115 (2008)). In an intraperitoneal administration test in female rats, abdominal tumors were observed in 4/32 animals (one mesothelioma in the peritoneumand 3 sarcomas) (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 115 (2008)). Soluble inorganic nickel is classified into "A4" in ACGIH (ACGIH (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	An increase in spontaneous abortions was observed in female mice administered the substance by gavage (ATSDR (2005)). In oral tests in female rats, embryonic mortality was increased (IARC No. 49 (1990)) and an increased frequency of runts and greater prenatal and neonatal mortality were observed (EHC No. 108 (1991)). In an intraperitoneal test in rats, abnormalities included hydrocephalus, hydronephrosis and heart defect (IARC No. 49 (1990)). Since remarkable fetal developmental toxicity was observed at doses in which general toxicity in parental animals was not manifested, the substance was classified into Category 1B. As relevant information, the substance is classified into Repr. Category 2; R61 in EU classification.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an inhalation test in rats, "hyperplasia of bronchiolar and accompanying bronchial epithelium with peribronchial lymphocyte infiltrates" was observed (EHC No. 108 (1991)). For this test, information about exposure durations is lacking, and the data is not suitable for classification purposes. In an oral test in rats, "excitation and increased motor activity, followed by depression of the nervous system" were observed at 430 mg/kg (male) and 529 mg/kg (female) which fall within the guidance value range for Category 2 (ECETOC TR33 (1989)). Based on the data, the substance was classified into Category 2 (nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 2 (lung, central nervous system)	Warning	H373	P260 P314 P501	In a 90-day oral test with rats, pneumonitis characterized by intra-alveolar accumulation of alveolar macrophages and atrophy of type II alveolar epithelial cells were reported in females (10/25) and males (7/25) at a dose level of 35 mg/kg which is within the guidance value range for Category 2 (Initial Risk Assessment Report (NITE, CERI, NEDO) ver. 1.0 No. 115 (2008)). Based on the data, the substance was classified into Category 2 (lung). In a learning ability test with rats by oral administration for 77 days, rate of lever pressing in rats treated with 20 mg Ni/kg bw/day which is within the guidance value range for Category 2, was lower than that in the controls. According to the authors, the reduced rate of lever pressing could be caused by decreases in fundamental sensory, coordinated movement and motivation due to nickel exposure (Initial Risk Assessment Report (NITE, CERI, NEDO) ver. 1.0 No. 115 (2008)). In a 90-day oral dose test in rats, mortality was 100% at 100 mg/kg/day, which is the upper limit of the guidance value range for Category 2. Decolorized tip of fur, salivation, loss of coordination, irregular respiration, hypothermia and lethargy were observed in both sexes in this dose level (Initial Risk Assessment Report (NITE, CERI, NEDO) ver. 1.0 No. 115 (2008)). In addition, effects of soluble inorganic nickel on the central nervous system are suggested in ACGIH classification (ACGIH TLV-Basis-Critical Effects: Central Nervous System; ACGIH-TLV (2004)). The substance was classified into Category 2 (central nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	In preparation. Check the Japanese version.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	In preparation. Check the Japanese version.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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