NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7727-54-0
Chemical Name	Diammonium peroxodisulfate
Substance ID	m-nite-7727-54-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	Since it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible inorganic compounds.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible inorganic compounds.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Category 3	Warning	H272	P370+P378 P210 P220 P280 P501	Since it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)), it was classified into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified into Category 4 from LD50 value of 495 mg/kg (female) (SIDS (2005), NICNAS (2001), IUCLID (2000)) of the oral administration test employing a rat (OECD TG 401, GLP). In addition, in EU classification, it is Xn; R22 (EU-Annex I) and is equivalent to Category 3-4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since LD50 value of the dermal administration test employing rats (OECD TG 402, GLP) was >2,000 mg/kg (SIDS (2005), NICNAS (2001), IUCLID (2000)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	LC50 value of 4-hour inhalation exposure test employing rats (OECD TG 403, GLP) is >2.95 mg/L (SIDS (2005), NICNAS (2001), IUCLID (2000)). When applying the dust standard due to a solid, classification cannot be specified, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	For animals, the descriptions of "zero of mean score value of erythema/ edema" (SIDS (2005)) and "edema having disappeared within 24 hours (NICNAS (2001)) have been shown in a 4-hour skin irritation/corrosion test in which non-diluted solution was applied to rabbits (OECD TG 404, GLP). For humans, "irritative" has been described in either the patch test in which a 5% solution of the substance was applied, or the test in which a 17.5% solution of the substance was applied for 4 hours (SIDS (2005)). SIDS (2005) has described "slightly irritating" for rabbits and "can cause skin irritation" in a 5% or more solution of the substance for humans as a conclusion. Therefore, it was classified into Category 2. In addition, it can be classified as Xi in the EU classification; R36/ 37/ 38 (EU-Annex I), being equivalent to Category 2-3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	For animals, there is a description of "The symptom of conjunctivitis was observed for 48 hours after application in slight to mild."(SIDS (2005)) in Draize test employing rabbits (OECD TG 405, GLP). Moreover, for the same test, there is also a description "The author of the literature has concluded that "This substance has eye irritation from the test result where conjunctivitis and iritis were observed in slight to mild."(NICNAS (2001)). As mentioned above, it was classified into Category 2B. In addition, the EU classification is Xi; R36/37/38 (EU-Annex I), and is equivalent to Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	For humans, it has been described that "2, 3, and 3 of 52 persons of manufacturing factory employees were positive to this substance alone, the related substance of Peroxydisulfuric acid dipotassium salt (CAS No.7727-21-1, hereinafter described as dipotassium salt) alone, and both of this substance and dipotassium salt, respectively. The correlation trend was indicated between positive results and slight decrease of lung function." in vivo immunological test (skin prick test) (SIDS (2005)). Moreover, there is also a report of occupational asthma in beauticians, and it has been concluded that "test results in humans show that the substance is a respiratory sensitizer in occupational exposure"in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1. Moreover, it can be displayed as Sah (ACGIH-TLV/BEI (2005)) in the German MAK list.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	About animals, it has been described that "it is suspicious since all of 20 animals were positive in hypodermic although being negative in dermal" (SIDS (2005)) in the maximization test with 20 guinea pig (OECD TG 406). About humans, it has been described that "12 of 49 beauticians were positive" in the patch test (SIDS (2005)), and it has also been described that "eczema, skin diseases, and pimples were developed" (SIDS (2005)) or that "allergic dermatitis was observed" (NICNAS (2001)) as occupational exposures in beauticians. It has been concluded that "test results in humans show that the substance is a skin sensitizer in occupational exposure" in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1. Moreover, it can be displayed as Sah (ACGIH-TLV/BEI (2005)) in the German MAK list.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is a description of "negative" (SIDS (2005) and NICNAS (2001)), respectively in the in vitro mutagenicity test (chromosome aberration test employing Chinese hamster ovaria fibroblasts and the Ames test employing a Salmonella typhimurium and bacillus coli), classification is not possible because there is no data of in vivo examination. In addition, there is a description of "negative" in the in vivo mutagenicity test (micronucleus test employing mouse erythrocyte) and in the in vivo genotoxicity test (UDS test using rat hepatocytes), respectively, for Disodium peroxydisulfate (CAS No.7775-27-1) which is a substance (SIDS (2005), NICNAS (2001)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no sufficient data, classification is not possible. In addition, the dermal administration test for 51 weeks employing female mice has a description that "there is no skin cancers promoter activity in this substance" (SIDS (2005)), and another description that "there is data of the skin cancer formation resulting from this substance, however, the size of study groups was small and dosing regimens didn't meet the guideline, therefore final conclusions cannot be drawn" (NICNAS (2001)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	It is reported that "no effects on fertility, fertility rate, fetal abnormality, fetal survival, sperm formation and spermatogenic cycle were observed until the highest dose of 250 mg/kg" (SIDS (2005)) in a reproductive/developmental toxicity screening study in rats (OECD TG 421, GLP). However, in this study the data on teratogenicity in the offspring is insufficient. Since there is no other experimental data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	In the oral administration test employing rats (OECD TG 401, GLP), "nerve tremor, salivation, dacryorrhea, paleness, locomotor activity reduction, and ataxia were observed. There is a description of "These symptoms have recovered within five days in living animals."(SIDS (2005)). This impact was seen within the limits of the guidance value of Category 2. Moreover, there is a description of "Respiratory distress was seen" in 4-hours inhalation exposure test employing rats (GLP) (SIDS (2005)). There is a description that, as a conclusion, "This substance shows Respiratory tract irritation in occupational exposure."(SIDS (2005)). As mentioned above, it was classified into Category 2 (central nervous system) and Category 3 (Respiratory tract irritation). In addition, ICSC (2001) has described that "Effect of short term exposure. : ... It irritates the respiratory tract. Inhalation of dust may cause an asthmatic reaction.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory system)	Warning	H373	P260 P314 P501	In animal case, in the 13-week inhalation exposure test to rats (OECD TG 413, GLP), "an increase in rale and rapid respiration" (SIDS (2005)) were observed in female rats within the limits of the guidance value of Category 1, and "an increase in hemoglobin value and hematocrit value, inflammation in the airway in female rats, an increase in rale, rapid respiration, weight reduction, decreased weight gains, feed intake reduction, an increase in the relative and absolute lung weight, an increase in relative brain weight, inflammation in the airway, excessive mucus secretion in the bronchi and, as a serious symptom, alveolar histiocytosis were observed in male and female rats" (SIDS (2005)) within the limits of the guidance value of Category 2Therefore, it is classified into Category 2 (respiratory systems). In addition, ICSC (2001) shows that "effects of long term or repeated exposure: repeated or prolonged inhalation exposure may cause asthma."	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 96-hour LC50 = 76.3 mg/L for fish (Oncorhynchus mykiss) (OECD SIDS: 2005).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC (biomass) = 39.2 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2005) despite unknown environmental dynamics of the inorganic compound. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 from 96-hour LC50 = 76.3 mg/L for fish (Oncorhynchus mykiss) (OECD SIDS: 2005) despite unknown environmental dynamics of the inorganic compound. From the above results, it was classified in Category 3.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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