NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7772-99-8
Chemical Name	Stannous chloride
Substance ID	m-nite-7772-99-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2004)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2004)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2004)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because data of water solubility of 900 g/L (20 deg C) (ICSC (2004)) were obtained, it is estimated that it does not react vigorously with water.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified	- -	-	-	It is a strong reducing agent (ICSC (2004)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	There are reports of 4 data of LD50 values for rats, 700 mg/kg (JECFA FAS 46 (addendum) (2001), NTP TR231 (1982)), > 1.5 g/kg (CICAD 65 (2005)), 2,275 mg/kg (fasted) and 3,200 mg/kg (feeding) (JECFA FAS 46 (addendum) (2001)), and 1 data of an LD50 value of the dihydrate for rats, 3,190 mg/kg (converted value as the anhydrate: 2,681 mg/kg) (DFGOT vol.14 (2000)). It was classified as "Not classified" (Category 5 in UN GHS classification) to which largest number (3 cases) of data corresponds.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are reports that in a skin irritation test with rabbits, no skin irritation occurred when a 5% aqueous solution of this substance was applied for 18 hours, but that in a human patch test, 5% and 10% solutions showed skin irritation (DFGOT vol.14 (2000)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a description that inorganic tin compounds may be irritating to the eyes (ATSDR (2005)). Because the description from ACGIH-TLV in the previous classification was information on organic tin compounds, it was deleted, and the category was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are reports that this substance showed no sensitization to rats (DFGOT vol.14 (2000)), and that it was positive in human patch tests (DFGOT vol.14 (2000)). However, these data were judged insufficient for use in the classification since the details are unknown.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, although it was negative in a mouse bone marrow micronucleus test and weakly positive in a sister chromatid exchange test, clear dose-dependency was not confirmed (CICAD 65 (2005), NTP DB (Access on September 2014)). As for in vitro, it was positive in a chromosomal aberration test and a sister chromatid exchange test with cultured mammalian cells, and negative in a bacterial reverse mutation test and a mammalian cell gene mutation test (ATSDR (2005), CICAD 65 (2005), NTP DB (Access on September 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	There is no classification of carcinogenicity for this substance by international evaluation organizations. As the result of carcinogenicity tests with rats and mice by NTP, an increased incidence of C-cell adenoma in the thyroid was observed in male rats, being considered to be equivocal, however, NTP concluded that it is not carcinogenic (NTP TR231 (1982), CICAD 65 (2005)). There are no other carcinogenicity test data. From the above, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Not classified	- -	-	-	In a three-generation reproductive toxicity test with rats dosed by the oral route (feeding), even at the highest dose (800 mg/kg/day), no effects were observed in the growth and fertility of parental animals and in the development of offspring, and no malformation was observed either. In addition, in teratogenicity tests with mice, rats and hamsters dosed by the oral route (gavage), although no parental animal toxicities were described, there is a report that no effects on implantations, fetal survival and the incidence of fetal malformations (skeletal and soft tissue) were observed (CICAD 65 (2005), ATSDR (2005)). From the above, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Because it is described that inorganic tin compounds are irritating to the mucous membranes (ATSDR (2005)), it was classified in Category 3 (respiratory tract irritation). Besides, it is reported that short-term oral administration of this substance to rats and mice induced effects on the central nervous system such as ataxia, general depression, limb weakness and flaccid paralysis, and renal lesions characterized by swelling and discoloration of the kidney, and tubular necrosis with subsequent regeneration (CICAD 65 (2005)). Moreover, although there is a report that necrosis was observed in the liver and the spleen by a single oral administration to mice (CICAD 65 (2005)), there is no description on the doses at which these findings were observed, and on the details as to whether the findings were for dead or surviving animals, therefore, it was impossible to adopt the above as indicators for the category.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney), Category 2 (blood system)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	There are no findings of hazard by repeated exposure to this substance in humans. Besides, there is a description in ACGIH (7th, 2001) that exposure to inorganic tin compounds is known to cause stannosis (mild pneumoconiosis) from inhalation exposure to the dust or fume of tin oxide, and TLV Recommendation is set up to general inorganic tin compounds except tin hydride (SnH4) based on the effects on the respiratory organs (ACGIH (7th, 2001)). However, because this substance is a water-soluble compound, being unlikely to be inhaled in the form of dust or fume like insoluble tin oxide, it was considered inappropriate to assign "respiratory organs" as a target organ. Therefore, it is impossible to identify the target organs based on human data. On the other hand, in experimental animals, numerous tests with rats, mice, or rabbits dosed by the oral route (mainly feeding) were conducted. There are also numerous tests in which no toxicological findings were observed at doses within or lower than the dose range of Category 2. Especially, in NTP studies where rats and mice were fed for 2 weeks, 13 weeks, and 2 years, only a mild effect on the gastrointestinal tract was observed at the higher dose of "Not classified" (CICAD 65 (2005), ATSDR (2005)). On another front, since the following tests results are findings indicating the target organ of this substance within or lower than the dose range of Category 2 and are listed as findings to set target organs in the evaluations by both CICAD and ATSDR, they are toxicity information available for classification. In a test in which rats were dosed by drinking water throughout their life from weaning until natural death, fatty degeneration of the liver and renal tubular vacuolization were observed within the dose range of Category 1 (equivalent to 8 mg/L: 0.7 mg/kg/day), and in a test in which rabbits were dosed by gavage for 4 months, transient anemia was observed at a ceiling dose of Category 1 (10 mg/kg/day) (CICAD 65 (2005), ATSDR (2005)). In addition, in a 13-week feeding administration test with rats, anemia (decreased hemoglobin concentration and hematocrit value) and changes in the liver tissue (proliferation in the bile duct epithelium) were observed at a ceiling dose of Category 2 (3,000 ppm (equivalent to 95 mg/kg/day)) (CICAD 65 (2005), ATSDR (2005)). Toxicity information on the experimental animals by the inhalation route was not obtained. From the above, based on findings in experimental animals, it was classified in Category 1 (liver, kidney), Category 2 (hemal system) for this hazard class. Besides, also refer to the classification results for the related substance, stannic chloride (ID: 55; CAS RN: 7646-78-8).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 72-hour EC50=200microg/L of the algae (Thalassiosira) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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