NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7775-11-3
Chemical Name	Sodium chromate
Substance ID	m-nite-7775-11-3_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
7	Flammable solids	Not classified	- -	-	-	Non-combustible inorganic compound (it is reported to be not combustible (ICSC)).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible inorganic compound.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible inorganic compound.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is a product made of this substance dissolved in water.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
14	Oxidizing solids	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	Since its rat LD50 = 40 mg/kg by oral administration (EU-RAR (2005)), the substance was classified into Category 2.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	Since its rabbit LD50 = 1330 mg/kg (EU-RAR (2002)), the substance was classified into Category 4.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since the substance is a solid (GHS definition), it was classified into the "Not applicable" category.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Since its rat LC50 = 0.104 mg/L (4 hours) (EU-RAR (2005)), the substance was classified into Category 2.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on the description that water-soluble Cr (VI) compounds are corrosive (EU-RAR (2005)), the substance was classified into Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on the description that water-soluble Cr (VI) compounds cause irreversible and severe damage to the eyes (EU-RAR (2005)), the substance was classified into Category 1. It has been classified into Category 1 for skin corrosion as well.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Cr (VI) compounds containing sodium salts are reported to cause respiratory tract sensitization in humans (EU-RAR (2005)). Thus, the substance was classified into Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Cr (VI) compounds containing sodium salts are reported to cause skin sensitization in guinea pigs (EU-RAR (2005)). Thus, the substance was classified into Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Cr (VI) compounds are rated as "Group 1" by the IARC (IARC vol. 49 (1996)), "Group 2" by the EU (EU 2007), and "Group 1" by Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits 2007). Based on these ratings, the substance was classified into Category 1A.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] There is no information on reproductive effects of this substance itself in humans or animals. However, because this substance is a water-soluble hexavalent chromium compound and is thought to act as hexavalent chromium in the body, it was judged that animal test data on sodium dichromate (CAS: 10588-01-9) and potassium dichromate (CAS: 7778-50-9) could be used for classification. As for experimental animals, mating test results on a water-soluble hexavalent chromium compound (potassium dichromate) were: (1) as the result of oral dosing females followed by mating with untreated males, or oral dosing females during a gestation period, pre-or post-implantation deaths/resorptions of embryos/fetuses were markedly observed in both rats and mice, and live fetuses showed subdermal hemorrhage and malformations in the tail in addition to low body weight; (2) adverse effects on sexual function (copulation, ejaculation) were found in males; (3) possibilities of various reproductive toxicity effects by causing functional/mechanical adverse effects on the ovary in females were indicated. Besides, repeated oral dosing of a water-soluble hexavalent chromium compound (potassium dichromate) caused disorders of male genetic organs and spermatogenesis as effects on males as written in (4). As from the above, effects on fertility and developmental effects found in oral administration tests on a water-soluble hexavalent chromium compound are thought to be applicable to this substance, however, knowledge on effects on humans by occupational exposure to hexavalent chromium is limited to (5). Therefore, this substance was classified in Category 1B. Besides, the classification result was revised by using information on a water-soluble hexavalent chromium compound, not this substance. [Evidence Data] (1) As the result of dosing female rats or mice with potassium dichromate for 20 days by drinking water followed by mating with untreated males, resorptions from pre-or post-implantation deaths of embryos/fetuses were evident, and live fetuses showed external anomalies such as subdermal hemorrhagic patches, kinky tails, and short tails in addition to low body weight and delayed skeletal formation. Moreover, also in a test in which pregnant mice were dosed with potassium dichromate by drinking water, subdermal hemorrhage and anomalies in the tails were found in fetuses at the maternal toxicity doses (CICAD (2013), ATSDR (2012), EU-RAR (2005)). (2) As the result of dosing male rats with potassium dichromate for 12 weeks by drinking water followed by mating with untreated females, a decreased number of mounts, lower percentage of ejaculating males, increased ejaculatory latency, and postejaculatory interval were observed as alterations in sexual behavior (CICAD (2013)). (3) As the result of dosing female rats with potassium dichromate for 20 days or 90 days by drinking water followed by mating with untreated males, decreases in female fertility index and male fertility index, increased pre-or post-implantation losses of embryos were found, and a decreased number of corpora lutea and extended or disturbed estrus cycles were observed in addition at the high doses. Moreover, as the result of dosing female mice with potassium dichromate for 20 days by drinking water, a reduction in the number of follicles at different stages of maturation, a decrease in the number of ovum/animal, histopathological alterations in the ovary (proliferated/dilatated blood vessels, pyknotic nuclei in follicular cells, atretic follicles) were observed (CICAD (2013), ATSDR (2012)). (4) Oral dosing male rats with sodium dichromate for 90 days caused testicular toxicity (histological/biochemical changes) and decreased spermatogenesis, and dosing male mice with potassium dichromate by diet for seven weeks caused degeneration in the seminiferous tubules, reduced sperm count, morphological defect of the sperms (CICAD (2013)). Moreover, in a test in male monkeys dosed with potassium dichromate for up to six months by drinking water, decreases in sperm count and motility were found after two months, and disrupted spermatogenesis and histopathological changes in the testis and epididymis (ductal obstruction, germ cell depletion, hyperplasia of the Leydig cells, Sertoli cell fibrosis) were observed after six months (ATSDR (2012)). [Reference Data, etc.] (5) It is reported in epidemiological surveys on sperm quality from occupational exposure to hexavalent chromium that increased rate of morphologically abnormal sperms, a decreased sperm count, and decreased sperm motility were observed (CICAD (2013), ATSDR (2012)). Besides, an increased incidence of toxicosis and complications during pregnancy and childbirth was reported among female workers of a dichromate production facility, however, the nature of the complications and toxicosis was not specified (CICAD (2013)). (6) In tests in which male rats were exposed to sodium dichromate for 90 days or six months by inhalation, anomaly in the testis was not observed. Besides, reproductive and developmental effects were not detected in a three-generation test with rats exposed to potassium dichromate by inhalation or other tests (CICAD (2013)). (7) As for sodium dichromate dihydrate (CAS: 7789-12-0), in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, at the dose where maternal animals showed general toxicity effects such as decreased food consumption and effects on the blood, stomach, and kidney, extension of gestation length was observed, but there were no effects on fertility, and effects on deliveries and offspring were not observed (JECDB (Accessed Jan. 2019)). (8) It was classified in Repr. 1B in EU CLP. Japan Society for Occupational Health (JSOH) classified chromium and its compounds in reproductive toxicants Group 3 (OEL Documentations (Reproductive toxicant classification) (Japan Society For Occupational Health (JSOH) 2014)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, kidney, liver)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There is a report that inhalation by humans of aqueous solutions of Cr (VI) mists have resulted in necrosis of the bronchi and edemas of the lungs. In addition, swallowing of the substance by humans resulted in liver and kidney damage (EU-RAR (2005)). Based on these results, the substance was classified into Category 1 (respiratory system, kidney, and liver).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, kidney)	Danger	H372	P260 P264 P270 P314 P501	Repeated exposure to Cr (VI) including sodium chromate in humans resulted in respiratory system and kidney damage (EU-RAR (2005)). Based on this report, the substance was classified into Category 1 (respiratory system and kidney).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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