NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7782-41-4
Chemical Name	Fluorine
Substance ID	m-nite-7782-41-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified	- -	-	-	It is not combustible (ICSC (J) (2001)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Category 1	Danger	H270	P370+P376 P220 P244 P403	This substance is oxidizing gases described in ISO 10156-2017. Compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1045).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Compressed gas	Warning	H280	P410+P403	From a boiling point of -188.13 deg C and a critical temperature of -129 deg C (HSDB (Access on August 2017)), it was classified as compressed gas. Compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1045).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on 185 ppm (converted 4-hour equivalent value: 92.5 ppm) (ATSDR (2003), PATTY (6th, 2012)) as the LC50 value for rats in a 1-hour inhalation exposure test, this substance was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There are descriptions that this substance is a severe skin irritant (ACGIH (7th, 2001), ATSDR (2003)), and that skin irritation in humans was observed at the concentration of 95-100 ppm (150-300 mg/m3) (PATTY (6th, 2012)). In addition, in a skin irritation test with rabbits, when the shaved backs were exposed to the gas of this substance for 0.2 seconds, an ischemic part about 1/4 inch in diameter, surrounded by an erythematous area was produced. There is a description that the ischemic part became eschar of the skin surface accompanied with skin fallout within 4 days, but it healed back to normal epidermis (ATSDR (2003)). Therefore, this substance was classified in Category 2. Besides, this substance was classified as "Skin Corr. 1A" in EU CLP classification (ECHA CL Inventory (Access on July 2017)). The classification was changed based on the information obtained in this research.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	For human eyes, there is a description that this substance was very irritating at concentrations of 67-100 ppm. There is a description that marked irritation was shown at 100 ppm (155 mg/m3) of this substance (PATTY (6th, 2012)). There is a description that this substance shows severe eye irritation (ACGIH (7th, 2001)). Therefore, this substance was classified in Category 2A.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in the Food Safety Commission of Japan, as for the mutagenicity of fluorine, in an in-vitro mammalian cell test, a weak positive result was obtained, but in an in-vivo DNA damage test, it was judged that this substance was negative in a comprehensive manner, and it is considered that there is no genotoxicity which is a particular problem for living organisms (Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it was reported that as a result of inhalation exposure of this substance with rats at 18 ppm for 5 weeks, degeneration of the testes was observed, and it was classified in Category 2 based on this in the previous classification. However, since this information was judged to be used for classification of specific target organ toxicity (repeated exposure), it was not adopted.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In humans, it is reported that fever, coughing, chest tightness, rales, and cyanosis may develop after inhalation exposure to this substance at high levels, and it is described that these symptoms are indicative of developing delayed pulmonary oedema (EHC 36 (1984)). As for experimental animals, there is a report that in single inhalation exposure tests for 5-60 minutes with rats and mice, diffuse lung congestion, dyspnea, irritation, and alveolar necrosis were observed. There is a report that in single inhalation exposure tests for 5-60 minutes with mice, coagulation necrosis, periportal hemorrhages, and diffuse cloudy swelling in the liver, and focal coagulation necrosis in the renal cortex, focal lymphocyte infiltration in the cortex and medulla in the kidney were observed (above ATSDR (2003)). Effects on these experimental animals were observed at around 50-116 ppm (converted 4-hour equivalent value: 25-58 ppm), which is not higher than the LC50 value and is the dose equivalent to Category 1. Therefore, this substance was classified in Category 1 (respiratory organs, liver, kidney).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (bone, teeth, respiratory organs, reproductive organs (male))	Danger	H372	P260 P264 P270 P314 P501	In humans, there is no information on this substance. However, there is a report of lesions in bones related to fluorosis due to occupational exposure to inorganic fluorides (ACGIH (7th, 2001)). In addition, for fluorides, both beneficial and detrimental dental and skeletal effects have been observed in humans. Fluoride has been shown to decrease the prevalence of dental caries and, under certain conditions, has been used for the treatment of osteoporosis. However, it is described that excess fluoride can also result in dental fluorosis and can result in an increased prevalence of bone fractures in the elderly or patients with skeletal fluorosis (ATSDR (2003)). As for experimental animals, in 5-week inhalation toxicity tests with rats, rabbits, and dogs, no effects in rats, mild bronchial inflammation in rabbits, pulmonary hemorrhage and edema in dogs were observed at or above 2 ppm (converted guidance value: 0.7 ppm), which is within the guidance value of Category 1, and severe pulmonary irritation and testicular degeneration in rats, and hemorrhage in the lungs in rabbits were observed at 18 ppm (converted guidance value: 6 ppm) (ATSDR (2003)). From the above, this substance was classified in Category 1 (bone, teeth, respiratory organs, genetic organs (men)). Besides, the classification result differs from the previous classification because the influence of fluorides to humans was adopted as evidence for classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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