Item | Information |
---|---|
CAS RN | 7782-49-2 |
Chemical Name | Selenium |
Substance ID | m-nite-7782-49-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2009)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (2009)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2009)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From the result that it is insoluble in water (ICSC (2009)), it is estimated that it does not react vigorously with water. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound containing no oxygen or halogen. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on a report of an LD50 value for rats of 6,700 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003), ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH), 2000), EHC 85 (1986)), it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | There is a report of an LCLo value for rats of <= 33 mg/m3 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but by this data alone, it is not possible to specify the category to which the LC50 value corresponds, so it was classified as "Classification not possible." Besides, since the LCLo value was higher than the saturated vapor concentration (3.2 mg/m3), the reference value as the dust was applied. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Since selenium and its compounds were classified in Group 3 by IARC (suppl 7, 1987) and as D by EPA (1991), it was classified as "Classification not possible." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In reproductive toxicity tests with rats by the oral route (feeding), despite no description of general toxicity in parental animals, decreased fertility and postnatal death were reported (EHC 58 (1986)). However, the number of animals per group was as small as 2 males and 4-6 females, the reporting year, 1936, is long ago, and the test is different from the present reproductive test, so it was judged as insufficient data for classification and it was classified as "Classification not possible." The information for the previous classification was reviewed and the category was changed. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs, cardiovascular system, gastrointestinal tract) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
There are reports that in humans, this substance caused respiratory tract irritation by the inhalation route and dyspnea, bronchial spasms, bronchitis and chemical pneumonia in severe exposure (ATSDR (2003), HSDB (Access on August 2014), OEL Documentations (Japan Society For Occupational Health (JSOH), 2000), ACGIH (7th, 2001)), that the primary site of injury by acute inhalation exposure to the fumes and dust was the respiratory organs (ACGIH (7th, 2001), ATSDR (2003)), and that by oral ingestion, it caused acute selenium poisoning and there were gastrointestinal disorders, neuropathy, respiratory insufficiency, myocardial infarction and effects on cardiovascular systems (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), PATTY (6th, 2012), ATSDR (2003)). In experimental animals, there is a report that the primary site of injury by acute inhalation exposure to the dust was the respiratory organs (ATSDR (2003)). When rats were exposed by inhalation to 0.033 mg/L of the dust, severe respiratory effects including lung hemorrhage and pulmonary edema were observed, and interstitial pneumonitis was observed in surviving animals (ATSDR (2003)). In addition, mild interstitial pneumonitis, lung congestion, and slight emphysema were also observed by inhalation exposure of rabbits and guinea pigs to the dust (ATSDR (2003), HSDB (Access on August 2014)). These effects on the lungs were observed within the guidance value range corresponding to Category 1. From the above, this substance is reported to affect the central nervous system, respiratory organs, cardiovascular system and gastrointestinal tract in humans. On the other hand, in experimental animals, effects on the respiratory organs were observed in the concentration range corresponding to Category 1. Therefore, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, gastrointestinal tract). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory organs, liver) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Development of symptoms was observed in 35 out of 62 workers exposed to airborne selenium concentrations of 0.007-0.05 mg/m3 at a selenium refining plant, with nervous system and gastrointestinal symptoms such as headaches, sleeplessness, loss of appetite, and nausea in more than half of the workers, and with conjunctivitis and bronchitis in 9 workers (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2001), EHC 58 (1986)). Other than this, in workers exposed to a fume of metallic selenium and workers handling metallic selenium and sodium selenite, edema of the face, etc. and an enlarged liver (only in the latter) were observed. There is a case report that in long-term exposure to a mixed aerosol of metal selenium and selenium dioxide, rhinitis, nasal bleeding, and pain in the extremities developed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Data on repeated exposure of experimental animals to metal selenium are extremely limited. There is a description that after inhalation exposure of 33 mg/m3 to guinea pigs and rabbits every other day for 4 hours/time, 8 times, congestion of the lung and interstitial pneumonia and congestion and fatty degeneration of the liver in guinea pigs, and congestion of the lung and pneumonia in rabbits were observed (ATSDR (2003)). Although it is not available for classification, the information was considered to support the adverse findings in humans. Therefore, based on the findings in humans, it was classified in Category 1 (nervous system, respiratory organs, liver). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 4 |
- |
H413 | P273 P501 |
Although L(E) C50 <=100 mg/L data existed, since it was metal and the behavior in the water was unknown, it classified into Category 4. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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