NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7783-00-8
Chemical Name	Selenious acid
Substance ID	m-nite-7783-00-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2000)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2000)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2000)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because data of water solubility of 167 g/100 mL (20 deg C) (ICSC (2000)) were obtained, it is estimated that it does not react vigorously with water.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are reports of 4.8-7.0 mg/kg (ATSDR (2003), ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH, 2000)), EHC 85 (1986)) as LD50 values of selenium content in selenite for rats. When these values are converted to values of this substance, they are 7.7-11.3 mg/kg, which corresponds to Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There is a description that this substance caused chemical burns (EHC 58 (1986), HSDB (Access on July 2014)) and since it is considered to show skin corrosivity, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is no information on the effects on the eyes of this substance. However, since based on a description that this substance caused chemical burns (HSDB (Access on July 2014)), it was classified as Category 1 in the classification of skin corrosion/irritation, it was also classified in Category 1 for this hazard class.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified in Group 3 by IARC (suppl 7, 1987) and as D by EPA (2005), it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, as information in List 3, there is a report that no malformations developed below the doses where toxicity was manifested in parental animals in teratogenicity tests with rats, mice, rabbits, hamsters, and cynomolgus monkeys (Chemical Substance Hazard Data (CERI) 2001-39 (2), 2002). However, there are no data from List 1 and List 2 and no information on reproductive toxicity, therefore, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs, cardiovascular system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance was corrosive and irritating to the respiratory tract (ATSDR (2003), HSDB (Access on August 2014)). In humans, bronchospasm, cough, nausea, vomiting, syncope, tachycardia, tachypnea, slight hypotension, chills, diarrhea, headache, fever, cyanosis, dyspnea, leukocytosis and chemical pneumonitis were observed after inhalation exposure to the fume of this substance (HSDB (Access on August 2014)). Besides, by oral exposure, there is a report of salivation, garlic odor of breath, vomiting, diarrhea, severe gastrointestinal disorders, convulsions, shallow breath, elevated blood pressure, increased heart rate, adult respiratory distress syndrome, respiratory insufficiency, severe myopathy, metabolic acidosis, leukocytosis, hyperglycemia, cardiomyopathy, cardiac arrhythmia, moderate liver, kidney and lung dysfunction, neuropathy, respiratory insufficiency syndrome, myocardial infarction, renal failure and deaths by accidental ingestion, etc. of Gun Blue (gun blue: treatment agent of oxide film containing selenious acid, nitric acid and copper nitrate) containing this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003), HSDB (Access on August 2014), PATTY (6th, 2012)). From the above, since effects on the central nervous system, respiratory organs and cardiovascular system were observed by inhalation exposure of humans, and by oral exposure of humans, the central nervous system, respiratory organs, cardiovascular system, liver and kidney were considered to be the target organs in multiple cases due to ingestion of Gun Blue and other cases, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, liver, kidney).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory organs, blood system, liver, kidney, testis)	Danger	H372	P260 P264 P270 P314 P501	There were no adverse findings by repeated exposures to this substance in either humans or experimental animals. However, dogs or rats were exposed by inhalation to this substance and metallic selenium, and absorption rate and distribution, etc. were compared between them. As a result, based on findings of in vivo kinetics that this substance showed better absorption than metallic selenium, and the distribution and metabolic processes after absorption were almost the same (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003), EHC (1986)), it was considered that the toxicity of this substance is almost equivalent to that of metallic selenium. Therefore, based on metal selenium (CAS RN 7782-49-2), it was classified in Category 1 (nervous system, respiratory organs, liver). On the other hand, there are multiple studies in which the sodium salt of this substance (sodium selenite; CAS RN 10102-18-8) was orally administered to experimental animals and toxicities were considered equivalent to those by repeated oral exposures of this substance, so these were also used for GHS classification. In multiple studies where sodium selenite was administered by feeding to rats for 4-13 weeks, at doses corresponding to Category 1 (converted guidance value as sodium selenite: 0.0044-1.88 mg/kg/day), effects on the liver (centrilobular diffuse nodules, sinusoidal dilation, hepatocellular necrosis and portal infiltration of mononuclear cells, etc.), kidney (denaturation of renal papilla, necrosis), hemal system (decreased hemoglobin concentration, spleen enlargement), and testis (decreased weight, morphological abnormality of sperm, decreased sperm counts in the epididymis) were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003)). In addition, it is reported that in a study with guinea pigs administered by feeding for 60 days, at a dose within the range of Category 1 (15 ppm=0.75 mg Se/kg/day; converted to 90-day exposure of sodium selenite: 1.09 mg/kg/day), blood toxicity (anaemia, decreased lymphocytes) were observed, and that, also in a test with rats administered by feeding for 2 years, effects on the liver (degeneration of liver parenchyma, hyperplasia) and the kidney (nephritis) were observed at a dose (0.1 mg/kg/day) corresponding to Category 1 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003)). From the above, in consideration of the classification results of metal selenium subject to this by the inhalation route and sodium selenite by the oral route, it was classified in Category 1 (nervous system, respiratory organs, hemal system, liver, kidney, testis).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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